Results 161 to 170 of about 362,273 (289)

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells

Drug Design, Development and Therapy, 2015
Yong-Hui Ding,1,2 Zhi-Wei Zhou,2,3 Chun-Fang Ha,1 Xue-Yu Zhang,1 Shu-Ting Pan,4 Zhi-Xu He,3 Jeffrey L Edelman,2 Dong Wang,5 Yin-Xue Yang,6 Xueji Zhang,7 Wei Duan,8 Tianxin Yang,9 Jia-Xuan Qiu,4 Shu-Feng Zhou2,3 1Department of Gynecology, General ...
Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang ZX, Zhang XJ, Duan W, Yang TX, Qiu JX, Zhou SF   +13 more
doaj  

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

Gastroenterology, 2014
Hongliang Wang, J. W. Perry, A. Lauring, P. Neddermann, R. de Francesco, Andrew W. Tai   +5 more
semanticscholar   +1 more source

Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective

Med Research, EarlyView.
ABSTRACT Molecular diagnostics have become an important adjunct to ultrasonography and fine‐needle aspiration (FNA) for thyroid nodules, especially in Bethesda III/IV cytology where malignancy risk is uncertain. This narrative review summarizes the diagnostic and prognostic value of key genomic drivers (BRAF V600E, RAS, RET, TERT, and selected fusions)
Guohui Xiao, Min Ding, Zhixue Min, Yihan Dong, Xuanye Cao, Qiang Lu, Cong Chen, Yahui Wu, Xin Guo, Zhen Wu, Jing Xie, Dan Xu, Haizhen Chen, Rongli Xie, Jian Fei   +14 more
wiley   +1 more source

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

Antimicrobial Agents and Chemotherapy, 2013
H. M. van der Schaar, P. Leyssen, H. Thibaut, A. D. De Palma, Lonneke van der Linden, Kjerstin Lanke, C. Lacroix, E. Verbeken, K. Conrath, A. Macleod, D. R. Mitchell, N. Palmer, Hervé van de Poël, M. Andrews, J. Neyts, F. V. van Kuppeveld   +15 more
semanticscholar   +1 more source

Regulatory B cells in the central nervous system: From immune regulation to neuroprotection

Neuroprotection, EarlyView.
Neuroinflammatory mechanisms and the therapeutic potential of regulatory B cells (Bregs). Following brain Injury (left panel) blood–brain barrier disruption facilitates the infiltration of peripheral leukocytes, including effector B cells (Beff) and effector T cells (Teff). This process triggers the activation of macrophages, astrocytes, and microglia,
Luiza Stanaszek, Miroslaw Janowski
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Plasmodesmata‐located proteins: The molecular hubs in noncell‐autonomous immunity

New Plant Protection, EarlyView.
Plasmodesmata serve as critical battlefields for plant immunity, regulated by diverse proteins. This article provides a comprehensive review of the regulatory mechanisms, challenges, and future directions concerning proteins located within plasmodesmata and their roles in plant defense responses.
Zheng Wu, Xiaoyi Shan
wiley   +1 more source

BRG1 orchestrates diabetic corneal neuropathy via PI3K/AKT-mediated glycolytic reprogramming. [PDF]

Eye Vis (Lond)
Deng Y, Chen W, Liao D, Hu J.
europepmc   +1 more source

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

Journal of Virology, 2009
J. Borawski, P. Troke, X. Puyang, V. Gibaja, Shanpeng Zhao, C. Mickanin, Juliet R. Leighton-Davies, Christopher J. Wilson, V. Myer, Ivan Cornellataracido, J. Baryza, John A. Tallarico, G. Joberty, M. Bantscheff, M. Schirle, T. Bouwmeester, J. Mathy, Kai Lin, T. Compton, M. Labow, B. Wiedmann, L. Gaither   +21 more
semanticscholar   +1 more source