Results 21 to 30 of about 317,690 (321)

Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-κB, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and CaMKKβ/LKB1/AMPK Pathways and Suppressing Oxidative Stress and Inflammation

Antioxidants, 2021
Liver damage induced by paracetamol overdose is the main cause of acute liver failure worldwide. In order to study the hepatoprotective effect of Sanghuangporus sanghuang mycelium (SS) on paracetamol-induced liver injury, SS was administered orally every
Wen-Ping Jiang, Jeng-Shyan Deng, Shyh-Shyun Huang, Sheng-Hua Wu, Chin-Chu Chen, Jung-Chun Liao, Hung-Yi Chen, Hui-Yi Lin, Guan-Jhong Huang   +8 more
doaj   +1 more source

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate [PDF]

, 2015
During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55(Gag) is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the
Amigorena, S., Banchio, C., Benaroch, P., Cabrini, M., de Saint Basile, G., Duette, G., Freed, E. O., Geffner, J., Gerber, P. P., Jancic, C., Moita, C. F., Moita, L. F., Ostrowski, M., Paoletti, L., Pietrasanta, L. I., Sigaut, L., von Bilderling, C.   +16 more
core   +1 more source

PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells [PDF]

, 2013
Localized synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] at clathrin coated pits (CCPs) is crucial for the recruitment of adaptors and other components of the internalization machinery, as well as for regulating actin dynamics during ...
A Benmerah, A Gassama-Diagne, A Le Bivic, A Oztan, AL Rozelle, AV Oleinikov, BA Potter, BM Collins, Brianne E. Docter, Christina M. Szalinski, Christopher J. Guerriero, CJ Guerriero, CJ Maples, CJ Merrifield, CJ Merrifield, CN Antonescu, D Padron, DJ James, DK Strickland, F Gong, F Martin-Belmonte, F Martin-Belmonte, G Apodaca, G Apodaca, G Di Paolo, G Di Paolo, G Rohde, G Spudich, G Spudich, Gerard Apodaca, H Ishihara, H Ishihara, HY Naim, HY Naim, I van den Bout, J Hyman, J Zheng, JC Loijens, JM Anderson, Joshua Z. Rappoport, JR Henkel, JZ Rappoport, KM Vasudevan, KM Weixel, L Fang, LA Volpicelli-Daley, LA Volpicelli-Daley, LM Traub, M Bens, M Jost, M Krauss, M Nagai, MA Barbieri, MA Lemmon, MA Lokuta, MA Puthenveedu, Manojkumar A. Puthenveedu, MG Ford, Núria M. Pastor-Soler, O Cremona, O Idevall-Hagren, Ora A. Weisz, P Khandelwal, P Varnai, PC Stolt, PP Breitfeld, R Rohatgi, R Rohatgi, R Rojas, R Rojas, R Zoncu, RV Stahelin, RW Holz, S Benesch, S Boulant, S Cui, S Hardy, S Mukherjee, SF Bairstow, SJ Mundell, SK Mishra, T Hyman, T Itoh, TA Gottlieb, V Haucke, Wily G. Ruiz, Y Aikawa, Y Wang, Youssef Rbaibi, YS Mao   +89 more
core   +3 more sources

Computational identification of signalling pathways in Plasmodium falciparum [PDF]

, 2011
Malaria is one of the world’s most common and serious diseases causing death of about 3 million people each year. Its most severe occurrence is caused by the protozoan Plasmodium falciparum.
Adebiyi, E. F., Brors, B., Eils, R., Isewon, Itunuoluwa, Oyelade, O. J.   +4 more
core   +2 more sources

Astaxanthin Inhibits p70 S6 Kinase 1 Activity to Sensitize Insulin Signaling

Marine Drugs, 2020
Astaxanthin (AST) is a carotenoid with therapeutic values on hyperglycemia and diabetic complications. The mechanisms of action of AST remain incompletely understood.
Chunmei Li, Bixia Ma, Junhong Chen, Yoonhwa Jeong, Xiulong Xu   +4 more
doaj   +1 more source

The multifaceted roles of PI3Kγ in hypertension, vascular biology, and inflammation [PDF]

, 2016
PI3Kγ is a multifaceted protein, crucially involved in cardiovascular and immune systems. Several studies described the biological and physiological functions of this enzyme in the regulation of cardiovascular system, while others stressed its role in ...
Carnevale, Daniela, Lembo, Giuseppe, Perrotta, Marialuisa   +2 more
core   +2 more sources

Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

Scientific Reports, 2017
Exendin-4 (EX-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake and to increase proopiomelanocortin (POMC) gene expression in the hypothalamus. In this study, we examined the potential neural mechanisms by which
Yan Yang, Pique P. Choi, Wanli W. Smith, Weijie Xu, Delin Ma, Zachary A. Cordner, Nu-Chu Liang, Timothy H. Moran   +7 more
doaj   +1 more source

Phosphatidylinositol 4-kinase IIIβ (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins

Scientific Reports, 2019
Phosphatidylinositol 4-kinase IIIβ (PI4KB) is a key enzyme of the Golgi system because it produces its lipid hallmark - the phosphatidylinositol 4-phosphate (PI4P).
D. Chalupska, B. Różycki, J. Humpolı́čková, L. Faltova, M. Klíma, E. Bouřa   +5 more
semanticscholar   +1 more source

Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA [version 3; peer review: 1 approved, 3 approved with reservations, 1 not approved]

Open Research Africa, 2023
Background Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ), the long-acting components of the artemisinin-based combination therapies (ACTs), are a cornerstone of malaria treatment in Africa.
Peter Mwitari, Francis Kimani, Daniel Kiboi, Brenda Muriithi, Jean Chepngetich, Kevin Thiong'o, Beatrice Gachie, Jeremiah Gathirwa, Mercy Jepkorir   +8 more
doaj  

Identification of novel regulators of STAT3 activity.

PLoS ONE, 2020
STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes.
Elina Parri, Heikki Kuusanmäki, Arjan J van Adrichem, Meri Kaustio, Krister Wennerberg   +4 more
doaj   +1 more source