Results 91 to 100 of about 18,744,545 (170)

Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [¹¹C]UCB-J and [¹⁸F]FDG PET Study [PDF]

Background: Patients with Lewy body diseases exhibit various degrees of cortical and subcortical hypometabolism. However, the underlying causes behind this progressive hypometabolism remain unresolved.
Borghammer P, Horsager J, Gottrup H, Schacht AC, Andersen KB, Danielsen EH, Klit H, Pavese N, Hansen AK, Brooks DJ   +9 more
core   +1 more source

Higher drinking frequency corresponds to lower synaptic density in people with alcohol use disorder

The Journal of Clinical Investigation
BACKGROUND Chronic alcohol use leads to synaptic dysfunction in preclinical studies. However, whether in vivo synaptic density deficits are found in people with alcohol use disorder (AUD) remains unclear.METHODS Thirty-two people with AUD (n = 17 women ...
Yasmin Zakiniaeiz, Nakul R. Raval, Will Riordan, Nabeel Nabulsi, Yiyun Huang, Brian Pittman, David Matuskey, Gustavo A. Angarita, Robin Bonomi, Sherry A. McKee, Ansel T. Hillmer, Kelly P. Cosgrove   +11 more
doaj   +1 more source

Measurement of synaptic density in Down syndrome using PET imaging: a pilot study

Scientific Reports
Down syndrome (DS) is the most prevalent genetic cause of intellectual disability, resulting from trisomy 21. Recently, positron emission tomography (PET) imaging has been used to image synapses in vivo.
Alexandra DiFilippo, Erin Jonaitis, Renee Makuch, Brianna Gambetti, Victoria Fleming, Gilda Ennis, Todd Barnhart, Jonathan Engle, Barbara Bendlin, Sterling Johnson, Benjamin Handen, Sharon Krinsky-McHale, Sigan Hartley, Bradley Christian   +13 more
doaj   +1 more source

SV2A PET imaging in human neurodegenerative diseases

Frontiers in Aging Neuroscience
This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a biomarker for synaptic integrity using Positron Emission Tomography (PET) in neurodegenerative diseases.
Mahsa Shanaki Bavarsad, Lea T. Grinberg
doaj   +1 more source

Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study. [PDF]

Brain, 2022
Holland N, Malpetti M, Rittman T, Mak EE, Passamonti L, Kaalund SS, Hezemans FH, Jones PS, Savulich G, Hong YT, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB.   +13 more
europepmc   +1 more source

SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes [PDF]

Introduction: We investigated hippocampal synaptic density using synaptic vesicle 2A positron emission tomography (PET), and its association with amyloid beta (Aβ) and cognitive performance in healthy apolipoprotein E (APOE) ε4 carriers.Methods: Synaptic
Tuisku, Jouni, Koivumäki, Mikko, Karrasch, Mira, Rajander, Johan, Snellman, Anniina, Rinne, Juha O., Wahlroos, Saara, Aarnio, Richard, Ekblad, Laura L.   +8 more
core   +1 more source

Molecular neuroimaging of Parkinson's disease: association of motor and non-motor symptoms with synaptic density, dopaminergic and serotonergic systems

NeuroImage: Reports
Parkinson's disease (PD) is a neurodegenerative disease characterised by molecular and structural brain changes detectable through advanced imaging. Understanding alterations in neurotransmitter systems and synaptic density, and their clinical relevance,
Julia J. Schubert, Silvia Rota, Lucia Batzu, Pavlos Zinzalias, Nazneen Barwick, Sarah Lee, Mattia Veronese, Alastair D. Reith, Christine A. Parker, Steve C.R. Williams   +9 more
doaj   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

ePosters Virtual

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Dose reduction for synaptic density PET imaging in Parkinson’s disease

NeuroImage
Objective: Dynamic PET imaging with 11C-UCB-J enables in vivo quantification of synaptic vesicle glycoprotein 2A (SV2A), with prior reports of lower synaptic density in areas such as the brainstem nuclei and substantia nigra (SN) in Parkinson’s disease ...
Andi Li, Mika Naganawa, Praveen Honhar, Kathryn Fontaine, Paul Gravel, David Matuskey, Richard E. Carson, Jing Tang   +7 more
doaj   +1 more source