Results 81 to 90 of about 18,744,545 (170)

Coupling between global gray matter BOLD activity and CSF movement is associated with Aβ and tau burden in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Reduced glymphatic clearance may contribute to Alzheimer's disease. Low‐frequency CSF flow, which mediates glymphatic clearance, has tight temporal coupling (i.e., anti‐correlation) to global gray matter activity in resting‐state BOLD‐fMRI. But this coupling strength may decrease with AD.
Gawon Cho, Ryan S O'Dell, Xiao Liu, Helene Benveniste, Daniel Kay, Christopher H van Dyck, Brienne Miner, Adam P Mecca   +7 more
wiley   +1 more source

The relationship between cortical synaptic terminal density marker SV2A and glutamate early in the course of schizophrenia: a multimodal PET and MRS imaging study

Translational Psychiatry
Loss of glutamatergic terminals is hypothesised to contribute to excitation-inhibition imbalance in schizophrenia, supported by evidence that the normal positive association between glutamate concentrations and synaptic terminal density is not found in ...
Ellis Chika Onwordi, Thomas Whitehurst, Ekaterina Shatalina, Richard Carr, Ayla Mansur, Atheeshaan Arumuham, Martin Osugo, Tiago Reis Marques, Sameer Jauhar, Susham Gupta, Sofia Pappa, Ravi Mehrotra, Maja Ranger, Nikola Rahaman, Eugenii A. Rabiner, Roger N. Gunn, Sridhar Natesan, Oliver D. Howes   +17 more
doaj   +1 more source

Synaptic vesicle glycoprotein 2A is affected in the CNS of Huntington\u2019s Disease mice and post-mortem human HD brain

, 2021
: Synaptic dysfunction is a primary mechanism underlying Huntington\u2019s Disease (HD) progression. This study investigated changes in synaptic vesicle glycoprotein 2A (SV2A) density by means of 11C-UCB-J microPET imaging in the central nervous system ...
Dominguez, Celia, Bard, Jonathan, Stroobants, Sigrid, Mrzljak, Ladislav, Wyffels, Leonie, Munoz-Sanjuan, Ignacio, Verhaeghe, Jeroen, Staelens, Steven, Skinbjerg, Mette, Liu, Longbin, Bertoglio, Daniele, Miranda, Alan, Alan Miranda, Leonie Wyffels, Steven Staelens, Celia Dominguez, Longbin Liu, Jeroen Verhaeghe, Mette Skinbjerg, Sigrid Stroobants, Daniele Bertoglio, Ladislav Mrzljak, Jonathan Bard, Ignacio Munoz-Sanjuan   +23 more
core   +1 more source

Reduced synaptic density in patients with Lewy body dementia: an [¹¹C]UCB-J PET imaging study [PDF]

Background: Patients with Parkinson’s disease (PD) often develop dementia but the underlying substrate is incompletely understood. Generalized synaptic degeneration may contribute to dysfunction and cognitive decline in Lewy body dementias, but in vivo ...
Borghammer P, Damholdt MF, Horsager J, Gottrup H, Andersen KB, Danielsen EH, Klit H, Skjærbæk C, Hansen AK, Brooks DJ   +9 more
core   +2 more sources

An in vivo PET/CT investigation of mitochondrial complex 1, sigma 1, and synaptic vesicle 2 A in patients with amyotrophic lateral sclerosis

Neurobiology of Disease
Background: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder which pathology is still largely unclear. Objectives: To perform an in vivo cross-sectional investigation of mitochondrial complex 1 (MC1), synaptic vesicle 2 A ...
Edoardo R. de Natale, Joji P. Verghese, Alana Terry, Heather Wilson, Pegah Khosropanah, Holly Wright, Luca Passamonti, Karleyton C. Evans, Robert A. Comley, Hideo Tsukada, Jan Passchier, Graham Searle, Ekaterina Pererva, Alex Whittington, Roger Gunn, Eugenii A. Rabiner, Marios Politis   +16 more
doaj   +1 more source

Healthy brain aging assessed with [¹⁸F]FDG and [¹¹ C]UCB-J PET [PDF]

Background: The average human lifespan has increased dramatically over the past century. However, molecular and physiological alterations of the healthy brain during aging remain incompletely understood.
Borghammer P, Damholdt MF, Schacht AC, Andersen KB, Knudsen K, Hansen AK, Brooks DJ   +6 more
core   +1 more source

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

Alzheimer’s Research & Therapy
Background The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD).
Elaheh Salardini, Ryan S. O’Dell, Em Tchorz, Nabeel B. Nabulsi, Yiyun Huang, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca   +7 more
doaj   +1 more source

Kinetic evaluation and test–retest reproducibility of [¹¹C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans

, 2017
Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals. Here we report kinetic modeling and test–retest reproducibility assessment of the SV2A positron emission tomography (PET) radioligand [11C]UCB-J in humans.
Ming-Kai Chen, David Matuskey, Jean-Dominique Gallezot, Joël Mercier, Nabeel B Nabulsi, Shannan Henry, Richard E Carson, Yiyun Huang, Jonas Hannestad, Shu-fei Lin, Sjoerd J Finnema   +10 more
core   +1 more source

Data_Sheet_1_Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease.pdf

, 2021
Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been ...
Morten Juhl (3412343), Patrick MacDonald Fisher (4420039), Pontus Plavén-Sigray (4966531), Gitte Moos Knudsen (8804990), Ida Nymann Petersen (1622404), Annesofie Videbæk (11720540), Nakul Ravi Raval (11720528), Ida Vang Andersen (11720534), Mikael Palner (3766207), Matthias Manfred Herth (11567922), Nikolaj Speth (11720537), Jens D. Mikkelsen (160806), Frederik Gudmundsen (11720531)   +12 more
core   +1 more source

Synaptic loss and its association with symptom severity in Parkinson’s disease

npj Parkinson's Disease
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD and other ...
Sophie E. Holmes, Praveen Honhar, Sule Tinaz, Mika Naganawa, Ansel T. Hilmer, Jean-Dominique Gallezot, Mark Dias, Yanghong Yang, Takuya Toyonaga, Irina Esterlis, Adam Mecca, Christopher Van Dyck, Shannan Henry, Jim Ropchan, Nabeel Nabulsi, Elan D. Louis, Robert Comley, Sjoerd J. Finnema, Richard E. Carson, David Matuskey   +19 more
doaj   +1 more source