Results 71 to 80 of about 18,744,545 (170)

sj-pdf-1-jcb-10.1177_0271678X231200423 - Supplemental material for Evaluating infusion methods and simplified quantification of synaptic density in vivo with [¹¹C]UCB-J and [¹⁸F]SynVesT-1 PET

, 2023
Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231200423 for Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PET by Ruth H Asch, Mika Naganawa, Nabeel Nabulsi, Yiyun Huan ...
Yiyun Huan (16944127), Richard E Carson (7905236), Irina Esterlis (5498264), Ruth H Asch (16944124), Nabeel Nabulsi (2856149), Mika Naganawa (355348)   +5 more
core   +1 more source

Neuroprotection trial design in progressive supranuclear palsy: challenges and solutions

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION We review the specific challenges posed to neuroprotective trial design by progressive supranuclear palsy (PSP), a rare disorder difficult to diagnose and to assess quantitatively. METHODS Focusing on reducing the size and cost of trials, we review elements of PSP neuroprotection trial methodology and formulate a new minimum ...
Lawrence I. Golbe, Ronald G. Thomas
wiley   +1 more source

Preliminary evidence for preserved synaptic density in late-life depression

Translational Psychiatry
Late-life depression has been consistently associated with lower gray matter volume, the origin of which remains largely unexplained. Recent in-vivo PET findings in early-onset depression and Alzheimer’s Disease suggest that synaptic deficits contribute ...
Thomas Vande Casteele, Maarten Laroy, Margot Van Cauwenberge, Michel Koole, Patrick Dupont, Stefan Sunaert, Jan Van den Stock, Filip Bouckaert, Koen Van Laere, Louise Emsell, Mathieu Vandenbulcke   +10 more
doaj   +1 more source

Tracking early cognitive decline in preclinical AD with brain MRI similarity

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Early detection of neuroanatomical changes in preclinical Alzheimer's disease (AD) is critical for timely intervention. However, conventional magnetic resonance imaging (MRI) and fluid biomarkers often lack sensitivity to subtle structural alterations in early disease stages. METHODS To identify early brain alterations, we applied
Jiawei Sun, Blanca Zufiria‐Gerbolés, Massimiliano Passaretti, Giovanni Volpe, Mite Mijalkov, Joana B. Pereira, for the Alzheimer's Disease Neuroimaging Initiative   +6 more
wiley   +1 more source

Alzheimerin taudin APP/PS1-21-hiirimallin synapsitiheyden muutosten tutkiminen SV2A-proteiiniin sitoutuvalla [11C]UCB-J-radiomerkkiaineella

, 2023
Alzheimerin tauti on aivoja rappeuttava etenevä muistisairaus, josta kärsii maailmanlaajuisesti yli 55 miljoonaa ihmistä. Alzheimerin taudin patogeneesiin kuuluvat β-amyloidikertymät, tau-proteiinivyyhdit ja synapsien sekä hermosolujen toimintahäiriöt ja
Eisala, Mira
core  

Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning

EJNMMI Physics
Purpose Synaptic vesicle glycoprotein 2 A (SV2A) in human brains is an important biomarker of synaptic loss associated with several neurological disorders.
Xinyuan Zheng, Patrick Worhunsky, Qiong Liu, Xueqi Guo, Xiongchao Chen, Heng Sun, Jiazhen Zhang, Takuya Toyonaga, Adam P. Mecca, Ryan S. O’Dell, Christopher H. van Dyck, Gustavo A. Angarita, Kelly Cosgrove, Deepak D’Souza, David Matuskey, Irina Esterlis, Richard E. Carson, Rajiv Radhakrishnan, Chi Liu   +18 more
doaj   +1 more source

Long‐term forgetting, sleep, and tau in autosomal‐dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Accelerated long‐term forgetting (ALF) may represent one of the earliest cognitive changes in Alzheimer's disease (AD). However, whether ALF emerges in the preclinical stage of autosomal‐dominant AD (ADAD) is unclear, and its underlying mechanisms are poorly understood.
Jason C. You, Alex C. Bender, Courtney Berezuk, Daisy T. Noriega‐Makarskyy, Ana Baena, Diana Munera, Enmanuelle Pardilla‐Delgado, Liliana Ramirez‐Gomez, David Aguillon, Averi Giudicessi, Jairo E. Martinez, Alice Cronin‐Golomb, Alice D. Lam, Yakeel T. Quiroz   +13 more
wiley   +1 more source

Impact of Prior Intravenous Immunoglobulin and Plasmapheresis on Eculizumab or Ravulizumab Treatment for Generalized Myasthenia Gravis: An Analysis of the MG SPOTLIGHT Registry

Clinical and Experimental Neuroimmunology, Volume 17, Issue 1, February 2026.
ABSTRACT Objective The complement component 5 inhibitor therapies (C5ITs) eculizumab and ravulizumab are approved for the treatment of generalized myasthenia gravis (gMG). We evaluated the real‐world effectiveness and safety of eculizumab and ravulizumab in patients with gMG with or without prior intravenous immunoglobulin (IVIg) or plasma exchange ...
Akiyuki Uzawa, Ema Rodrigues, Hiroyuki Murai   +2 more
wiley   +1 more source

Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H. [PDF]

, 2017
peer reviewedIntroduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET).
Salmon, Eric, Luxen, André, André Luxen, Joël Aerts, Alain Seret, Buchanan, Tim, Mohamed Ali Bahri, Guillaume Becker, Tim Buchanan, Aerts, Joël, Christine Bastin, Plenevaux, Alain, Eric Salmon, Becker, Guillaume, Mestdagh, Nathalie, Seret, Alain, Nathalie Mestdagh, Mercier, Joël, Alain Plenevaux, Didier Ledoux, Anne Valade, Bahri, Mohamed Ali, Joël Mercier, Valade, Anne, Bastin, Christine, LEDOUX, Didier   +25 more
core   +1 more source

Mapping Alzheimer's disease heterogeneity with molecular imaging biomarkers

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
This review outlines positron emission tomography (PET) biomarkers used in Alzheimer's disease (AD) research and clinical settings, targeting both specific (amyloid, tau) and non‐specific (neurodegeneration, synaptic density, neuroinflammation) processes.
Elif Harput, Cecilia Boccalini, Gregory Mathoux, John O. Prior, Nathalie Testart, Mario Jreige, Valentina Garibotto   +6 more
wiley   +1 more source