Results 51 to 60 of about 18,744,545 (170)
Additional file 15 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET
, 2022 Additional file 15. The % bias (mean + SD) estimated for the parametric methods of interest against corresponding SRTM estimates using 60 minutes data.Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V. +20 moreopenaire +1 more sourceSynaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration
Nature Communications, 2023 There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models ...David J. Whiteside, Negin Holland, Kamen A. Tsvetanov, Elijah Mak, Maura Malpetti, George Savulich, P. Simon Jones, Michelle Naessens, Matthew A. Rouse, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, Eoin Mulroy, Kailash P. Bhatia, Timothy Rittman, John T. O’Brien, James B. Rowe +16 moredoaj +1 more sourceImaging Synaptic Density: The Next Holy Grail of Neuroscience?
Frontiers in Neuroscience, 2022 The brain is the central and most complex organ in the nervous system, comprising billions of neurons that constantly communicate through trillions of connections called synapses.Maria Elisa Serrano, Maria Elisa Serrano, Eugene Kim, Eugene Kim, Marija M. Petrinovic, Marija M. Petrinovic, Federico Turkheimer, Diana Cash, Diana Cash +8 moredoaj +1 more sourceWONOEP appraisal: Biomarkers and treatment strategies beyond the synapse
Epilepsia, Volume 67, Issue 10, Page 5026-5041, October 2026.Abstract
Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.Mirte Scheper, Zining Liu, Aristea S. Galanopoulou, Gernot Hlauschek, Benjamin Sinclair, Wai Lam Leung, Stefanie Dedeurwaerdere, Elisabeth Doran, Solomon L. Moshé, David C. Henshall, Ozlem Akman, Pablo M. Casillas‐Espinosa +11 morewiley +1 more sourceASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease – Study Protocol and Baseline Characteristics
Frontiers in Neurology, 2022 BackgroundDetailed characterization of early pathophysiological changes in preclinical Alzheimer's disease (AD) is necessary to enable development of correctly targeted and timed disease-modifying treatments.Anniina Snellman, Anniina Snellman, Laura L. Ekblad, Mikko Koivumäki, Noora Lindgrén, Jouni Tuisku, Merja Perälä, Lila Kallio, Riina Lehtonen, Virva Saunavaara, Virva Saunavaara, Jani Saunavaara, Vesa Oikonen, Richard Aarnio, Eliisa Löyttyniemi, Riitta Parkkola, Mira Karrasch, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Kaj Blennow, Kaj Blennow, Juha O. Rinne +24 moredoaj +1 more sourceGLP‐1 receptor agonists in Alzheimer's disease and MCI: a meta‐analysis
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 4, October/December 2026.Abstract INTRODUCTION
Alzheimer's disease (AD) is the leading cause of dementia in older individuals and remains a major clinical and socioeconomic burden. Despite the success of anti‐amyloid therapies in reducing biomarker burden, more effective and safer treatments are still needed.Ryan G. P. Siqueira, Carlotta Ranalli, Duygu Yılmaz, Meire da Silva, Bernardo Raposo Pinel Maltez, Giovanni Gosch Berton, Jeffrey L. Cummings +6 morewiley +1 more sourceAdditional file 16 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET
, 2022 Additional file 16. TRT (%) values estimated for specific brain regions (grey matter) are presented for SA VT and K1.Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V. +20 moreopenaire +1 more sourceAdditional file 17 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET
, 2022 Additional file 17. TRT (%) values estimated for specific brain regions (grey matter) are presented for SRTM2 BPND and R1.Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V. +20 moreopenaire +1 more sourceTwelve-Week Yoga vs. Aerobic Cycling Initiation in Sedentary Healthy Subjects: A Behavioral and Multiparametric Interventional PET/MR Study
Frontiers in Psychiatry, 2021 Interventional yoga studies with an active control group remain scarce and are important to clarify the underlying neurobiology. We conducted an interventional study in healthy controls using simultaneous positron emission tomography/magnetic resonance ...June van Aalst, Lise Jennen, Koen Demyttenaere, Koen Demyttenaere, Stefan Sunaert, Stefan Sunaert, Michel Koole, Jenny Ceccarini, Koen Van Laere, Koen Van Laere +9 moredoaj +1 more sourceAlzheimer's disease heterogeneity and co‐pathologies: Defining novel targets, biomarkers, modalities, and research methodologies
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.Abstract Alzheimer's disease (AD) is a biologically heterogeneous condition with vascular, proteinopathic, metabolic, and immune processes jointly shaping its clinical expression, trajectory of progression, and response to therapeutic intervention.Malú Gámez Tansey, Sasha Bozeat, Peter Ackerman, Alireza Atri, Christopher J. Barnum, Patrik Brundin, Carlos Abreu de Carvalho, Adam S. Fleisher, Ana Graf, Elizabeth Head, Geoffrey A. Kerchner, Hartmuth C. Kolb, Akihiko Koyama, Mariel Kozberg, Cheryl E. G. Leyns, Jorge J. Llibre‐Guerra, Niklas Mattsson‐Carlgren, David McKissock, Melissa E. Murray, Liana S. Rosenthal, Carrie Rubel, Suzanne E. Schindler, Julie A. Schneider, Adam J. Schwarz, Kirsten M. Scott, Tamara Seredenina, Duygu Tosun, Rebecca L. Wallings, Hong Wang, Donna M. Wilcock, Maria Carrillo, Simin Mahinrad, Christopher J. Weber +32 morewiley +1 more source
