Results 41 to 50 of about 18,744,545 (170)

PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats

Neurobiology of Disease, 2021
Alpha-synuclein (a-syn) can aggregate and form toxic oligomers and insoluble fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies are a major pathological characteristic of Parkinson's disease (PD).
Majken B. Thomsen, Sara A. Ferreira, Anna C. Schacht, Jan Jacobsen, Mette Simonsen, Cristine Betzer, Poul H. Jensen, David J. Brooks, Anne M. Landau, Marina Romero-Ramos   +9 more
doaj   +1 more source

Additional file 1 of Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A

, 2022
Additional file 1: Fig. S1. 11C-UCB-J activity curves in putamen (closed circles) with model fits (solid curves). a and b Displacement (LEV, 1500 mg at 60 min) and post-dose scans, c and d displacement (BRV, 200 mg at 60 min) and post-dose scans.
Ralph Paul Maguire (14080598), Sjoerd J. Finnema (1408846), Nabeel B. Nabulsi (9944247), Sophie Kervyn (14080604), Jean-Marie Nicolas (675471), Richard E. Carson (2563657), Yiyun Huang (2563660), Mika Naganawa (9676245), Jean-Dominique Gallezot (2856140), Henrik Klitgaard (14080613), Jonas Hannestad (14080610), Ming-Kai Chen (8328354), Joël Mercier (14080601), Armel Stockis (14080616), Shannan Henry (14080607)   +14 more
core   +1 more source

Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [¹¹C]UCB-J and [¹⁸F]FDG PET Study [PDF]

, 2023
\ua9 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Background: Patients with Lewy body diseases exhibit variable degrees of cortical and subcortical ...
Poston KL, Borghammer P, Horsager J, Gottrup H, Schacht AC, Andersen KB, Danielsen EH, Klit H, Pavese N, Hansen AK, Brooks DJ   +10 more
core   +4 more sources

S13. IN VIVO EVIDENCE OF REDUCED SYNAPTIC VESICLE DENSITY IN SCHIZOPHRENIA USING [11C] UCB-J PET IMAGING [PDF]

Schizophr Bull, 2019
Radhakrishnan R, Skosnik P, Ranganathan M, Naganawa M, Finnema S, Esterlis I, Huang Y, Nabulsi N, Carson R, D’Souza D.   +9 more
europepmc   +3 more sources

sj-pdf-1-jcb-10.1177_0271678X211047759 - Supplemental material for Changes in synaptic density in the subacute phase after ischemic stroke: A ¹¹C-UCB-J PET/MR study

, 2021
Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211047759 for Changes in synaptic density in the subacute phase after ischemic stroke: A 11C-UCB-J PET/MR study by Laura Michiels, Nathalie Mertens, Liselot Thijs, Ahmed Radwan, Stefan Sunaert, Mathieu ...
Laura Michiels (11474446), Geert Verheyden (3419258), Michel Koole (419670), Stefan Sunaert (407984), Robin Lemmens (606822), Nathalie Mertens (8088881), Ahmed Radwan (82736), Mathieu Vandenbulcke (674078), Koen Van Laere (8088887), Liselot Thijs (3419273)   +9 more
core   +1 more source

Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study [PDF]

, 2021
The relationship between in vivo synaptic density and tau burden in primary tauopathies is key to understanding the impact of tauopathy on functional decline and in informing new early therapeutic strategies.

core   +2 more sources

New Perspectives in Radiological and Radiopharmaceutical Hybrid Imaging in Progressive Supranuclear Palsy: A Systematic Review

Cells, 2023
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by four-repeat tau deposition in various cell types and anatomical regions, and can manifest as several clinical phenotypes, including the most common phenotype, Richardson’
Joachim Strobel, Hans-Peter Müller, Albert C. Ludolph, Ambros J. Beer, Nico Sollmann, Jan Kassubek   +5 more
doaj   +1 more source

Additional file 18 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 18. TRT (%) values estimated for specific brain regions (grey matter) are presented for RPM BPND and R1.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
openaire   +1 more source

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Nature Communications, 2020
Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [11C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and unaffected by ...
Ellis Chika Onwordi, Els F. Halff, Thomas Whitehurst, Ayla Mansur, Marie-Caroline Cotel, Lisa Wells, Hannah Creeney, David Bonsall, Maria Rogdaki, Ekaterina Shatalina, Tiago Reis Marques, Eugenii A. Rabiner, Roger N. Gunn, Sridhar Natesan, Anthony C. Vernon, Oliver D. Howes   +15 more
doaj   +1 more source

Apathy in Lewy Body Disorders: A Position Paper

Movement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky, Lidia Bojtos, Milica G. Kramberger, Elisa Mantovani, Iulia Murasan, Jose‐Alberto Palma, Karolina Poplawska‐Domaszewicz, Anna Sauerbier, Kallol Ray Chaudhuri, Per Odin, Daniel Weintraub, Anette Schrag, Cristian Falup‐Pecorariu   +12 more
wiley   +1 more source