Results 21 to 30 of about 18,744,545 (170)

Additional file 19 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 19. Coefficients of determination (r2) and slopes of parametric [11C]UCB-J VT, K1 and BPND against corresponding 1T2k_VB estimates for HCs using 90 minutes data. All the Hammers ROIs were included for this analysis.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
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Additional file 20 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 20. Coefficients of determination (r2) and slopes of parametric [11C]UCB-J BPND and R1 against corresponding SRTM estimates using 90 minutes data. All the Hammers ROIs were included for this analysis.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
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In vivo tau pathology is associated with synaptic loss and altered synaptic function

Alzheimer’s Research & Therapy, 2021
Background The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investigate spatial ...
Emma M. Coomans, Deborah N. Schoonhoven, Hayel Tuncel, Sander C. J. Verfaillie, Emma E. Wolters, Ronald Boellaard, Rik Ossenkoppele, Anouk den Braber, Wiep Scheper, Patrick Schober, Steven P. Sweeney, J. Michael Ryan, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Sandeep S. V. Golla, Arjan Hillebrand, Alida A. Gouw, Bart N. M. van Berckel   +19 more
doaj   +2 more sources

Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J [PDF]

EJNMMI Research, 2020
The ability to quantify synaptic density in vivo in human adults and adolescents is of vital importance to understanding neuropsychiatric disorders.
Jason Bini, Daniel Holden, Kathryn Fontaine, Tim Mulnix, Yihuan Lu, David Matuskey, Jim Ropchan, Nabeel Nabulsi, Yiyun Huang, Richard E. Carson   +9 more
doaj   +2 more sources

Evaluation of the impact of low activity imaging in [11C]-(+)-PHNO and [11C]UCB-J PET-MR scans [PDF]

EJNMMI Physics
Introduction Positron Emission Tomography (PET) imaging is a close ally of Precision Medicine, and it has been proven to be indispensable in the field of Psychiatry.
Daniela Ribeiro, William Hallett, Oliver Howes, Robert McCutcheon, Matthew M. Nour, David Nutt, David Erritzoe, Claudio Agnorelli, Stephen Husbands   +8 more
doaj   +2 more sources

Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease [PDF]

Frontiers in Synaptic Neuroscience, 2021
Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been ...
Nakul Ravi Raval, Nakul Ravi Raval, Frederik Gudmundsen, Morten Juhl, Ida Vang Andersen, Ida Vang Andersen, Nikolaj Speth, Annesofie Videbæk, Ida Nymann Petersen, Jens D. Mikkelsen, Jens D. Mikkelsen, Patrick MacDonald Fisher, Matthias Manfred Herth, Matthias Manfred Herth, Pontus Plavén-Sigray, Gitte Moos Knudsen, Gitte Moos Knudsen, Mikael Palner, Mikael Palner, Mikael Palner   +19 more
doaj   +2 more sources

Additional file 13 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 13. Coefficients of determination (r2) and slopes of parametric [11C]UCB-J VT, K1 and BPND against corresponding 1T2k_VB estimates separately for all subjects. All the Hammers ROIs were included for this analysis. Regional parametric values from both test and retest scans were pulled together for these comparisons.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
openaire   +2 more sources

Additional file 14 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 14. Coefficients of determination (r2) and slopes of parametric [11C]UCB-J BPND and R1 against corresponding SRTM estimates separately for all subjects. All the Hammers ROIs were included for this analysis. Regional parametric values from both test and retest scans were pulled together for these comparisons.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
openaire   +2 more sources

Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J [PDF]

Alzheimer’s Research & Therapy, 2021
Background Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies.
Ryan S. O’Dell, Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Tyler A. Godek, Joanna E. Harris, Hugh H. Bartlett, Emmie R. Banks, Victoria L. Kominek, Wenzhen Zhao, Nabeel B. Nabulsi, Jim Ropchan, Yunpeng Ye, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck   +19 more
doaj   +2 more sources

Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue

Molecular Imaging and Biology, 2019
The aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([11C]methyl)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([11C]UCB-J) parametric maps using white matter (centrum semi-ovale-SO) as reference tissue.Ten healthy volunteers (8 M/2F; age 27.6 ± 10.0 years) underwent a 90-min dynamic [11C]UCB ...
Nathalie Mertens, Ralph Paul Maguire, Kim Serdons, Brigitte Lacroix, Joel Mercier, David Sciberras, Koen Van Laere, Michel Koole   +7 more
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