Results 11 to 20 of about 18,744,545 (170)

11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies [PDF]

European Journal of Hybrid Imaging, 2020
Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer’s disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using positron emission
Nicolas Nicastro, Negin Holland, George Savulich, Stephen F. Carter, Elijah Mak, Young T. Hong, Selena Milicevic Sephton, Tim D. Fryer, Franklin I. Aigbirhio, James B. Rowe, John T. O’Brien   +10 more
doaj   +7 more sources

Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis [PDF]

NeuroImage, 2021
Background: The human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations.
Xiaotian T. Fang, Takuya Toyonaga, Ansel T. Hillmer, David Matuskey, Sophie E. Holmes, Rajiv Radhakrishnan, Adam P. Mecca, Christopher H. van Dyck, Deepak Cyril D'Souza, Irina Esterlis, Patrick D. Worhunsky, Richard E. Carson   +11 more
doaj   +4 more sources

In Vivo Imaging of Synaptic SV2A Protein Density in Healthy and Striatal-Lesioned Rats With [11C]UCB-J PET [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2021
The number of functionally active synapses provides a measure of neural integrity, with reductions observed in neurodegenerative disorders. [11C]UCB-J binds to synaptic vesicle 2A (SV2A) transmembrane protein located in secretory vesicles. We aimed to assess [11C]UCB-J PET as an in vivo biomarker of regional cerebral synaptic SV2A density in rat lesion
Majken B Thomsen, Anne M. Landau, Marina Romero-Ramos   +2 more
exaly   +7 more sources

Automated Radiosynthesis of [11C]UCB-J for Imaging Synpatic Density by PET [PDF]

, 2020
An automated radiosynthesis of carbon-11 PET radiotracer [11C]UCB-J for imaging the synaptic density biomarker synaptic vesicle glycoprotein SV2A was established using Synthra RNPlus synthesizer. Commercially available trifluoroborate UCB-J analogue was used as a radiolabelling precursor and the desired radiolabelled product was isolated in 11 ± 2% (n =
Milicevic Sephton, Selena, Miklovicz, Tunde, Russell, Joseph J, Doke, Aniruddha, Li, Lei, Boros, Istvan, Aigbirhio, Franklin I   +6 more
openaire   +4 more sources

Quantitative imaging of mitochondrial and synaptic function in the human brain with 18F-BCPP-EF, 11C-SA-4503, and 11C-UCB-J [PDF]

, 2020
The ‘Molecular Imaging of Neurodegenerative Disease: Mitochondria, Associated Proteins & Synapses’ (MIND-MAPS) Consortium was formed to investigate three potential molecular markers of the mitochondrial/endoplasmic reticulum/synaptic axis dysfunction associated with neurodegeneration using positron emission tomography (PET) in the healthy human ...
Middleton, Lefkos T, Comley, Robert A, Gunn, Roger N, Passchier, Jan, Lewis, Yvonne, Rabiner, Euigenii A, Mansur, Ayla, Huiban, Mickael, Tsukada, Hideo, ?, ?   +9 more
core   +8 more sources

In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

NeuroImage, 2021
The positron emission tomography (PET) radioligand [11C]UCB-J binds to synaptic vesicle protein 2A (SV2A) and is used to investigate synaptic density in the living brain.
Mengfei Xiong, Sahar Roshanbin, Johanna Rokka, Eva Schlein, Martin Ingelsson, Dag Sehlin, Jonas Eriksson, Stina Syvänen   +7 more
doaj   +2 more sources

Identification of pre-synaptic density networks using [11C]UCB-J PET imaging and ICA in mice

NeuroImage, 2022
Background: Synaptic vesicle glycoprotein 2A (SV2A) is a vesicle glycoprotein involved in neurotransmitter release. SV2A is located on the pre-synaptic terminals of neurons and visualized using the radioligand [11C]UCB-J and positron emission tomography (
Jordy Akkermans, Franziska Zajicek, Alan Miranda, Mohit H. Adhikari, Daniele Bertoglio   +4 more
doaj   +4 more sources

Synaptic density in carriers of C9orf72 mutations: a [11C]UCB‐J PET study [PDF]

Annals of Clinical and Translational Neurology, 2021
Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [11C]UCB‐J PET to quantify synaptic density in comparison with 19 ...
Maura Malpetti, Negin Holland, P. Simon Jones, Rong Ye, Thomas E. Cope, Tim D. Fryer, Young T. Hong, George Savulich, Timothy Rittman, Luca Passamonti, Elijah Mak, Franklin I. Aigbirhio, John T. O’Brien, James B. Rowe   +13 more
doaj   +2 more sources

Synaptic Density in Healthy Human Aging Is Not Influenced by Age or Sex: A 11C-UCB-J PET Study

NeuroImage, 2021
Rationale: 11C-UCB-J binds to synaptic vesicle glycoprotein 2A, a protein ubiquitously expressed in presynaptic nerve terminals, and can therefore serve as in vivo proxy of synaptic density.
Koen Van Laere, Michel Koole, Aline Delva   +2 more
exaly   +3 more sources

Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [11C]UCB-J PET study in a model of obsessive–compulsive disorder-like behaviour [PDF]

EJNMMI Research, 2020
Background Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-
Dorien Glorie, Jeroen Verhaeghe, Alan Miranda, Stef De Lombaerde, Sigrid Stroobants, Steven Staelens   +5 more
doaj   +2 more sources