Results 31 to 40 of about 18,744,545 (170)

Additional file 1 of Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET

, 2022
Additional file 1. Region of interest definition on HRRT PET Images - Top row: Sagittal view of early (0-10 mins) summed baseline (left) and blocking (right) [11C]UCB-J PET uptake images scaled to brain uptake (A) and scaled to spinal cord uptake (B).
Rossano, Samantha, Toyonaga, Takuya, Bini, Jason, Nabulsi, Nabeel, Ropchan, Jim, Cai, Zhengxin, Huang, Yiyun, Carson, Richard E.   +7 more
openaire   +2 more sources

Plasma β-synuclein associates with hippocampal synaptic density measured with [¹¹C]UCB-J PET and plasma tau markers in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Plasma β‐synuclein is a promising blood‐based synaptic biomarker, but relationships with synaptic density as indicated by [11C]UCB‐J positron emission tomography (PET), and blood biomarkers of Alzheimer's disease (AD) pathology, neurodegeneration, and astrocyte activation need further characterization.
Peter DC, McLachlan M, DiFilippo AH, Yang KL, Pasquesi ME, Barnhart TE, Engle JW, Betthauser TJ, Asthana S, Johnson SC, Christian BT, Bendlin BB, Otto M, Oeckl P.   +13 more
europepmc   +2 more sources

Synaptic vesicle protein SV2A imaging with [11C]UCB‐J as a novel biomarker of neurodegeneration in Alzheimer's disease [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundSynaptic loss is a known feature of symptomatic Alzheimer’s disease (AD). Conversely, abundance of synapses may confer resilience to cognitive decline in the presence of AD pathology. Currently, the extent and distribution of synapse loss during the asymptomatic stages of AD is unknown. Synaptic vesicle glycoprotein 2A (SV2A) is found
Barbara B Bendlin, Alexandra H DiFilippo, Tobey J Betthauser, Nathaniel A Chin, Dhanabalan Murali, Nicholas M Vogt, Grace McKinney, Nancy J Davenport, Todd E Barnhart, Jonathan W Engle, Sterling C Johnson, Bradley T Christian   +11 more
openaire   +1 more source

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Translational Psychiatry, 2021
Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic function in vivo.
Ellis Chika Onwordi, Thomas Whitehurst, Ayla Mansur, Ben Statton, Alaine Berry, Marina Quinlan, Declan P. O’Regan, Maria Rogdaki, Tiago Reis Marques, Eugenii A. Rabiner, Roger N. Gunn, Anthony C. Vernon, Sridhar Natesan, Oliver D. Howes   +13 more
doaj   +1 more source

The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study. [PDF]

Imaging Neurosci (Camb)
Abstract Synaptic terminal density is thought to influence cognitive function and neural activity, yet its role in cognition has not been explored in healthy humans. We examined these relationships using [11C]UCB-J positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) in 25 healthy adults performing ...
Shatalina E, Onwordi EC, Whitehurst T, Whittington A, Mansur A, Arumuham A, Statton B, Berry A, Marques TR, Gunn RN, Natesan S, Nour MM, Rabiner EA, Wall MB, Howes OD.   +14 more
europepmc   +4 more sources

In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET [PDF]

The number of functionally active synapses provides a measure of neural integrity, with reductions observed in neurodegenerative disorders. [11C]UCB-J binds to synaptic vesicle 2A (SV2A) transmembrane protein located in secretory vesicles.
Romero-Ramos M, Thomsen MB, Schacht AC, Jacobsen J, Lillethorup TP, Landau AM, Simonsen M, Brooks DJ   +7 more
core   +4 more sources

Additional file 12 of Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET

, 2022
Additional file 12. The % bias (mean + SD) estimated for the parametric methods of interest against corresponding 1T2k_VB estimates using 60 minutes data.
Tuncel, Hayel, Boellaard, Ronald, Coomans, Emma M., Hollander-Meeuwsen, Marijke den, de Vries, Erik F. J., Glaudemans, Andor W. J. M., Feltes, Paula Kopschina, García, David Vállez, Verfaillie, Sander C. J., Wolters, Emma E., Sweeney, Steven P., Ryan, J. Michael, Ivarsson, Magnus, Lynch, Berkley A., Schober, Patrick, Scheltens, Philip, Schuit, Robert C., Windhorst, Albert D., De Deyn, Peter P., van Berckel, Bart N. M., Golla, Sandeep S. V.   +20 more
openaire   +1 more source

Synaptic Terminal Density Early in the Course of Schizophrenia: an in vivo UCB-J Positron Emission Tomographic Imaging Study of Synaptic Vesicle Glycoprotein 2A (SV2A) [PDF]

, 2023
Background: The synaptic hypothesis is an influential theory of the pathoaetiology of schizophrenia. Supporting this, there is lower uptake of the synaptic terminal density marker UCB-J in patients with chronic schizophrenia compared to controls. However,
Shatalina, Ekaterina, Rabiner, Eugenii A., Onwordi, Ellis Chika, Gupta, Susham, Mehrotra, Ravi, Whitehurst, Thomas, Gunn, Roger N., Arumuham, Atheeshaan; id_orcid, Jauhar, Sameer; id_orcid, Reis Marques, Tiago, Osugo, Martin; id_orcid, Natesan, Sridhar, Mansur, Ayla, Howes, Oliver   +13 more
core   +1 more source

Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16

Frontiers in Neurology, 2023
IntroductionSynapse loss is one of the hallmarks of Alzheimer's disease (AD) and is associated with cognitive decline. In this study, we tested [18F]SDM-16, a novel metabolically stable SV2A PET imaging probe, in the transgenic APPswe/PS1dE9 (APP/PS1 ...
Chao Zheng, Takuya Toyonaga, Baosheng Chen, LaShae Nicholson, William Mennie, Michael Liu, Joshua Spurrier, Kristin Deluca, Stephen M. Strittmatter, Richard E. Carson, Yiyun Huang, Zhengxin Cai   +11 more
doaj   +1 more source

Synaptic terminal density early in the course of schizophrenia: an in vivo UCB-J positron emission tomographic imaging study of SV2A [PDF]

, 2023
BACKGROUND: The synaptic hypothesis is an influential theory of the pathoaetiology of schizophrenia. Supporting this, there is lower uptake of the synaptic terminal density marker UCB-J in patients with chronic schizophrenia compared to controls. However,
Ellis Chika Onwordi, Gunn, Roger N, Ekaterina Shatalina, Onwordi, Ellis Chika, Gupta, Susham, Mehrotra, Ravi, Oliver D. Howes, Whitehurst, Thomas, Arumuham, Atheeshaan, Howes, Oliver D, Jauhar, Sameer, Susham Gupta, Osugo, Martin, Marques, Tiago Reis, Martin Osugo, Osugo, Martin; id_orcid, Ravi Mehrotra, Eugenii A. Rabiner, Sridhar Natesan, Atheeshaan Arumuham, Mansur, Ayla, Shatalina, Ekaterina, Roger N. Gunn, Rabiner, Eugenii A., Ayla Mansur, Howes, Oliver D., Thomas Whitehurst, Sameer Jauhar, Gunn, Roger N., Arumuham, Atheeshaan; id_orcid, Rabiner, Eugenii A, Tiago Reis Marques, Natesan, Sridhar, Jauhar, Sameer; id_orcid, Reis Marques, Tiago, Howes, Oliver   +35 more
core   +1 more source