Results 101 to 110 of about 18,744,545 (170)

Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [¹¹ C]UCB-J Positron Emission Tomography Study. [PDF]

Mov Disord, 2023
Holland N, Jones PS, Savulich G, Naessens M, Malpetti M, Whiteside DJ, Street D, Swann P, Hong YT, Fryer TD, Rittman T, Mulroy E, Aigbirhio FI, Bhatia KP, O'Brien JT, Rowe JB.   +15 more
europepmc   +1 more source

Evaluating infusion methods and simplified quantification of synaptic density in vivo with [¹¹C]UCB-J and [¹⁸F]SynVesT-1 PET. [PDF]

J Cereb Blood Flow Metab, 2023
Asch RH, Naganawa M, Nabulsi N, Huan Y, Esterlis I, Carson RE.   +5 more
europepmc   +1 more source

Synaptic Loss in Frontotemporal Dementia Revealed by [¹¹ C]UCB-J Positron Emission Tomography. [PDF]

Ann Neurol, 2023
Malpetti M, Jones PS, Cope TE, Holland N, Naessens M, Rouse MA, Rittman T, Savulich G, Whiteside DJ, Street D, Fryer TD, Hong YT, Milicevic Sephton S, Aigbirhio FI, O Brien JT, Rowe JB.   +15 more
europepmc   +1 more source

Evaluating the pharmacodynamic effects of padsevonil in healthy volunteers using simultaneous [¹¹C]-UCB-J PET and MR Arterial Spin Labeling measurements. [PDF]

Neurosci Appl, 2023
Koole M, Lacroix B, Tang C, Chanteux H, Maguire RP, Van Laere K.   +5 more
europepmc   +1 more source

Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study

The Journal of Clinical Investigation
Alcohol use disorder (AUD) is linked with changes in brain structure and function, with robust evidence for neurodegenerative changes, including synaptic loss in preclinical models.
Sarah K. Royse, Rajesh Narendran
doaj   +1 more source

Synaptic signaling modeled by functional connectivity predicts metabolic demands of the human brain

NeuroImage
Purpose: The human brain is characterized by interacting large-scale functional networks fueled by glucose metabolism. Since former studies could not sufficiently clarify how these functional connections shape glucose metabolism, we aimed to provide a ...
Sebastian Klug, Matej Murgaš, Godber M Godbersen, Marcus Hacker, Rupert Lanzenberger, Andreas Hahn   +5 more
doaj   +1 more source

Fibre density and cross-section associate with hallmark pathology in early Alzheimer’s disease

Alzheimer’s Research & Therapy
Background Tau pathology in Alzheimer’s disease (AD) propagates trans-synaptically along structurally connected brain networks and in synergy with amyloid pathology it induces synaptic damage.
Greet Vanderlinden, Ahmed Radwan, Daan Christiaens, Jeroen Blommaert, Stefan Sunaert, Mathieu Vandenbulcke, Michel Koole, Koen Van Laere   +7 more
doaj   +1 more source

Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [¹¹ C]UCB-J. [PDF]

Alzheimers Dement, 2022
Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen MK, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH.   +16 more
europepmc   +1 more source

Effects of cognitive training under hypoxia on cognitive proficiency and neuroplasticity in remitted patients with mood disorders and healthy individuals: ALTIBRAIN study protocol for a randomized controlled trial

Trials
Background Cognitive impairment is prevalent across neuropsychiatric disorders but there is a lack of treatment strategies with robust, enduring effects.
Kamilla Woznica Miskowiak, Viktoria Damgaard, Johanna Mariegaard Schandorff, Julian Macoveanu, Gitte Moos Knudsen, Annette Johansen, Pontus Plaven-Sigray, Claus Svarer, Caroline Bruun Fussing, Katrine Cramer, Martin Balslev Jørgensen, Lars Vedel Kessing, Hannelore Ehrenreich   +12 more
doaj   +1 more source

Changes in synaptic density in the subacute phase after ischemic stroke: A ¹¹C-UCB-J PET/MR study. [PDF]

J Cereb Blood Flow Metab, 2022
Michiels L, Mertens N, Thijs L, Radwan A, Sunaert S, Vandenbulcke M, Verheyden G, Koole M, Van Laere K, Lemmens R.   +9 more
europepmc   +1 more source