Results 61 to 70 of about 71,224 (157)

Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid

Scientific Reports, 2017
Several studies have shown that docosahexaenoic acid (DHA) attenuates epileptic seizures; however, the molecular mechanism by which it achieves this effect is still largely unknown.
Yasuhiro Ishihara, Kouichi Itoh, Miki Tanaka, Mayumi Tsuji, Toshihiro Kawamoto, Suguru Kawato, Christoph F. A. Vogel, Takeshi Yamazaki   +7 more
doaj   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Methods for long-term 17β-estradiol administration to mice

, 2012
Rodent models constitute a cornerstone in the elucidation of the effects and biological mechanisms of 17β-estradiol. However, a thorough assessment of the methods for long-term administration of 17β-estradiol to mice is lacking.
E. Ingberg, Ström, Jakob O,, Theodorsson, Annette,, J.O. Strom, Theodorsson, E.,, Theodorsson, Elvar,, A. Theodorsson, E. Theodorsson, Ingberg, Edvin,, Ström, Jakob O.,, Theodorsson, A.,   +10 more
core   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Comparing Transcriptomic Responses to Chemicals Across Six Species Using the EcoToxChip RNASeq Database

Environmental Toxicology and Chemistry, EarlyView.
Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal, Jessica Ewald, Doug Crump, Jessica Head, Markus Hecker, Natacha Hogan, Jianguo Xia, Niladri Basu   +7 more
wiley   +1 more source

Effect of Estradiol-17β on Placental Size [PDF]

, 2000
Meishan embryos transferred to recipient females on day 2.5 are larger, contain greater numbers of trophectoderm cells, and secrete greater amounts of estradiol-17β when gestated in a Yorkshire compared with Meishan uterus to day 12.
Ford, Stephen, Wilson, Matthew
core  

17β-estradiol effects on human coronaries and grafts employed in myocardial revascularization: a preliminary study

Journal of Cardiothoracic Surgery, 2006
Background This study was undertaken to compare the in vitro effects of 17β-estradiol on human epicardial coronary arteries, resistance coronary arteries and on arterial vessels usually employed as grafts in surgical myocardial revascularization. Methods
Penza Eleonora, Grillo Francesco, Topkara Veli K, Ossola Manuela, Dainese Luca, Rossoni Giuseppe, Barili Fabio, Polvani Gianluca, Tremoli Elena, Biglioli Paolo   +9 more
doaj   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Examples of genes significantly regulated by estradiol-17β (E2T), progesterone (P4T) and estradiol-17β+progesterone (E2P4T) treatment, grouped in 5 distinct clusters.

, 2013
Examples of genes significantly regulated by estradiol-17β (E2T), progesterone (P4T) and estradiol-17β+progesterone (E2P4T) treatment, grouped in 5 distinct clusters.
Alhaji U. N’Jai (459905), Milo C. Wiltbank (449022), Carla A. Piccinato (459904), Guilherme J. M. Rosa (230655), Colin R. Jefcoate (459906)   +4 more
core   +1 more source