Results 71 to 80 of about 71,224 (157)

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

Electrochemical Aptasensor for Endocrine Disrupting 17β-Estradiol Based on a Poly(3,4-ethylenedioxylthiopene)-Gold Nanocomposite Platform

Sensors, 2010
A simple and highly sensitive electrochemical DNA aptasensor with high affinity for endocrine disrupting 17β-estradiol, was developed. Poly(3,4-ethylenedioxylthiophene) (PEDOT) doped with gold nanoparticles (AuNPs) was electrochemically synthesized and ...
Emmanuel Iwuoha, Priscilla Baker, Omotayo Arotiba, Tesfaye T. Waryo, Stephen N. Mailu, Rasaq A. Olowu   +5 more
doaj   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

17β-estradiol Inhibits the Production of Interferon-induced Protein of 10kDa by Human Keratinocytes [PDF]

, 2003
The natural course of psoriasis is often modulated during pregnancy, indicating the regulatory effect of estrogen or progesterone on psoriasis. Interferon-induced protein of 10kDa chemoattracts T helper 1 cells, and interferon-induced protein of 10kDa ...
Kanda, Naoko, Watanabe, Shinichi
core   +1 more source

Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom‐driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology.
Hamza Kamran, Zaharadeen Jimoh, Tariq Issa, Nahla A. Gomaa   +3 more
wiley   +1 more source

Ion chromatograms and mass spectra (inset) of 17β-estradiol and its metabolites.

, 2015
(A) 17β-estradiol in the medium in absence of isolated hepatocytes; (B) 17β-estradiol in the medium in the presence of isolated hepatocytes. No 17β-estradiol was found after 6 h of cell culture; (C) identified 17β-estradiol metabolite estrone-3 ...
Gang Chen (107840), Ying Bai (107853), Dan Zhu (139675), Olena Doran (107874), Huda Al-Kateb (683878), Li Ren (417022), Meiying Fang (107868), Yanhua Li (279177)   +7 more
core   +1 more source

Protective effects of 17β-estradiol on Benzo(e)pyrene[B(e)P]-induced toxicity in ARPE-19 cells

Journal of Ophthalmic & Vision Research, 2018
Purpose: The aim of this study was to examine the effect of 17β-estradiol on Benzo(e)pyrene [B(e)P]-induced toxicity in ARPE-19 cells. Methods: We pretreated ARPE-19 cells with 20 nM and 40 nM 17β-estradiol for 6 hours, followed by addition of 300 μM B(e)
Ashish U Sapkal, Sonali Nashine, Saffar Mansoor, Vishal R Sharma, Claudio A Ramirez, Rafael Z Migon, Navin K Gupta, Marilyn Chwa, Baruch D Kuppermann, Cristina Kenney   +9 more
doaj   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Rapid effects of 17β-estradiol on hepatocytes

, 2008
17β-estradiol is the most potent circulating estrogenic hormone. The classical mode of action of 17β-estradiol involves its translocation to the nucleus and regulation of transcription.
Stratton, Rebecca Claire
core  

Bisphenols and Phthalates in Bottled Mineral Water: First Evidence of Co‐Occurrence, Estrogenic Activity, and Health Risk in Brazil

Environmental Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), its structural analogs, and phthalates are synthetic chemicals widely used, with documented endocrine‐disrupting activity. This study aimed to develop and validate a selective multiresidue analytical method for the simultaneous determination of BPA, 10 bisphenol analogs, and six phthalates in PET‐bottled mineral water.
Giulia Boito Reyes, Lucas Correia Gonçalves, Fernanda Cristina Iba Molinari, José Eduardo Gonçalves   +3 more
wiley   +1 more source