Results 111 to 120 of about 77,981 (327)

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Angewandte Chemie, EarlyView.
Macrocycles are effective molecular glues to stabilize the 14‐3‐3/ChREBP interaction. Linker length modulation uncovered an inverse correlation between the macrocycle binding affinity to 14‐3‐3 and its cooperativity in 14‐3‐3/ChREBP stabilization.
Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld   +7 more
wiley   +2 more sources

3D QSAR study on substituted 1, 2, 4 triazole derivatives as anticancer agents by kNN MFA approach. [PDF]

Saudi Pharm J, 2023
Desai SP, Mohite SK, Alobid S, Saralaya MG, Patil AS, Das K, Almadani ME, Arif Hussain S, Hussain Alamer B, Abdulrahman Jibreel E, Ibrahim Almoteer A, Mohammed Basheeruddin Asdaq S.   +11 more
europepmc   +1 more source

Biomolekuláris felismerésre képes makrociklusos receptorok szintézise = Synthesis of macrocyclic receptors capable of biomolecular recognition [PDF]

, 2013
1. Kalix-és binaftokorona éterek szintézise és alkalmazásuk 1.1. Kalix[6]arén Mitsunobu ciklizációját tanulmányoztuk 1,6-és 1,8-oktándiollal és a termékek konformációját meghatároztuk 1.2.
Bitter, István, Csókai, Viktor, Grün, Alajos   +2 more
core  

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Multi‐Crystal X‐Ray Diffraction (MCXRD) Bridges the Crystallographic Characterisation Gap in Chemistry and Materials Science: Application to MOFs

Angewandte Chemie, EarlyView.
Multi‐crystal X‐ray diffraction (MCXRD) methods allow accurate structural characterisation with crystals too small for single‐crystal X‐ray diffraction and too large for electron diffraction, as demonstrated here for metal‐organic frameworks, and alleviate the radiation‐induced chemical changes that can result from using high‐intensity X‐ray sources to
Joshua P. Smith, Rebecca Smith, Thomas M. Roseveare, Dominic Bara, Alexander J. R. Thom, Ross S. Forgan, Mark R. Warren, Anna J. Warren, Robin L. Owen, Lee Brammer   +9 more
wiley   +2 more sources

The synthesis and highly effective antibacterial properties of Cu-3, 5-dimethy l-1, 2, 4-triazole metal organic frameworks. [PDF]

Front Chem, 2023
Xu X, Ding M, Liu K, Lv F, Miao Y, Liu Y, Gong Y, Huo Y, Li H.   +8 more
europepmc   +1 more source

Direct evidence of a blocking heavy atom effect on the water-assisted fluorescence enhancement detection of Hg²⁺ based on a ratiometric chemosensor [PDF]

, 2014
At the current stage of chemosensor chemistry, the critical question now is whether the heavy atom effect caused by HTM ions can be blocked or avoided. In the present work, we provide unequivocal evidence to confirm that the heavy atom effect of Hg²⁺ is ...
Ni, Xin-Long, Redshaw, Carl, Wu, Yanan, Yamato, Takehiko   +3 more
core   +2 more sources

Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post‐Functionalization

Advanced Science, EarlyView.
In this work, we developed a post‐functionalization approach to achieve water‐soluble cyclic polyphthalaldehyde (cPPA) polymers via click chemistry. ABSTRACT Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli‐responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to
Liting He, Haiyan Zhou, Qiushi Chen, Xing Guo, Han Liu, Xuechen Li   +5 more
wiley   +1 more source

SÍNTESE E AVALIAÇÃO DA ATIVIDADE CITOTÓXICA DE DERIVADOS DO EUGENOL CONTENDO NÚCLEOS 1,2,3-TRIAZÓLICOS

Química Nova
Eugenol is an aromatic compound found in several plant species. It presents important biological activities including cytotoxicity. In this paper, it is described the synthesis and the evaluation of the cytotoxic activity of eugenol derivatives bearing 1,
Poliana Aparecida Rodrigues Gazolla, Róbson Ricardo Teixeira, Adalberto Manoel da Silva, Boniek Gontijo Vaz, Géssica Adriana Vasconcelos, Raoni Pais Siqueira, Victor Hugo Sousa Gonçalves, Higor Sette Pereira, Gustavo Costa Bressan   +8 more
doaj   +1 more source