Results 11 to 20 of about 77,981 (327)

1, 2, 4-Triazole Scafolds : Recent Advances and Pharmacological Applications [PDF]

International Journal of Current Research and Academic Review, 2016
Anjali Thakur, Puspraj S. Gupta, Parjanya Kumar Shukla, Amita verma, Prateek Pathak   +4 more
openalex   +2 more sources

An in silico investigation of 1,2,4-triazole derivatives as potential antioxidant agents using molecular docking, MD simulations, MM-PBSA free energy calculations and ADME predictions [PDF]

Pharmacia, 2023
In this study, we’ve performed computable studies of previously synthesized 1,2,4-triazole derivatives by virtual screening due to antioxidant activity. Six enzymes responsible for regulating oxidative stress were selected as key targets. One hundred and
Yevhen Karpun, Sergiy Fedotov, Anastasiia Khilkovets, Yuriy Karpenko, Volodymyr Parchenko, Yana Klochkova, Yuliia Bila, Iryna Lukina, Natalia Nahorna, Volodymyr Nahornyi   +9 more
doaj   +3 more sources

Analysis of biological properties of 1,2,4-triazole-containing compounds (literature review)

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
In the latest conditions of development and formation of the pharmaceutical industry, the introduction of new synthetic medicines requires continuous monitoring of the quality and safety of their use.
A. V. Khilkovets, V. V. Parchenko
doaj   +1 more source

Synthesis and properties of 7-((6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)methyl)theophyllines

Фармацевтичний журнал, 2023
The creation of new biologically active compounds is a promising area of modern medicinal chemistry. Heterocyclic systems play an important role in this process.Among them, it is necessary to note 1,2,4-triazole and xanthine, the presence of which in the
K. D. Bakumovska, A. S. Hotsulia
doaj   +1 more source

Effect of 4-benzylidenamino-5-phenyl-4Н-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4Н-1,2,4-triazole-3-ylthio)acetic acid on central component of nociceptive system

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Aim. To study the effect of 4-benzylideneamino-5-phenyl-4H-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4H-1,2,4-triazole-3-yltio)acetic acid on central component of nociceptive system on condition of thermal stimulation of limbs of rats ...
Ye. S. Pruhlo
doaj   +1 more source

In silico evaluation of the pharmacodynamic component of the interaction of S-alkyl derivatives of 5-methyl-4-(p-tolyl)-1,2,4-triazole-3-thiol with some biological targets

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
Derivatives of 1,2,4-triazole open wide opportunities for modern and progressive scientists in the development of innovative medicines. These compounds are known for their variability and structural flexibility, which allows scientists to experiment and ...
O. I. Panasenko, V. M. Odyntsova, A. S. Hotsulia   +2 more
doaj   +1 more source

weak intermolecular interactions and catalytic ethylene oligomerisation [PDF]

, 2012
The ligands 1-(cyclohexyl)-4-(2-pyridyl)-1,2,3-triazole (1), 1-(2,6-diisopropylphenyl)-4-(2-pyridyl)-1,2,3-triazole (2), 1-(4-butoxyphenyl)-4-(2-pyridyl)-1,2,3-triazole (3) and 1-(methyl)-4-(2-pyridyl)-1,2,3-triazole (4) were synthesized by the Cu(I ...
Braunstein, Pierre, Sarkar, Biprajit, Schweinfurth, David, Su, Cheng-Yong, Wei, Shi-Chao   +4 more
core   +1 more source

Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
1,2,4-Triazole derivatives are successfully used in medicine as antibacterial and antifungal agents. Aim of our research is the study of synthesis of 7'-((3-thio-4-ethyl-4H-1,2,4-triazole-5-yl)methyl)-3'-methylxanthine. Methods and results.
A. S. Gotsulya
doaj   +1 more source

(E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as synthons for the synthesis of xanthone-1,2,3-triazole dyads [PDF]

, 2015
Xanthone-1,2,3-triazole dyads have been synthesized by two different approaches, both starting from novel (E)-2-(4-arylbut-1-en-3-yn-1-yl)chromones, prepared through a base-catalyzed aldol reaction of 2-methylchromone and arylpropargyl aldehydes.
Alexacou, Arikan, Baker, Bennett, Chandrasekar, da Silva, Ee, El-Seedi, Esteves, Fan, Freitas, Genin, Herbrecht, Jiang, Kelkar, Khan, Kotha, Letcher, Letcher, Li, Mahal, Massarotti, Na, Oldenburg, Park, Pinto, Portela, Pothitirat, Price, Riscoe, Sakai, Santos, Silva, Silva, Silva, Sonogashira, Tretyakov, Vieira, Wadsworth, Zou   +39 more
core   +1 more source

Analgesic activity of the salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Despite the varied approaches to the pain syndrome therapy with the changes and improvements of evolutionary medicine’s development and the drugs which are used to treat pain there are still considerable difficulties in solving this problem. Aim.
V. M. Odintsova
doaj   +1 more source