Results 71 to 80 of about 97,768,553 (153)

High-Level De Novo Biosynthesis of 2′-Fucosyllactose by Metabolically Engineered Escherichia coli

, 2022
2′-Fucosyllactose (2′-FL) is the most abundant oligosaccharide in human milk. In this study, a highly efficient biosynthetic route for 2′-FL production was designed via the de novo pathway of GDP-l-fucose using engineered Escherichia coli BL21­(DE3 ...
Li Wan (11826), Roulin Chen (13046521), Yuanlin Liu (6369383), Yingying Zhu (331728), Wanmeng Mu (408651), Wenli Zhang (146408)   +5 more
core   +1 more source

The Effect of Human Milk Oligosaccharides and Bifidobacterium longum subspecies infantis Bi-26 on Simulated Infant Gut Microbiome and Metabolites

Microorganisms, 2023
Human milk oligosaccharides (HMOs) shape the developing infant gut microbiota. In this study, a semi-continuous colon simulator was used to evaluate the effect of 2 HMOs—2′-fucosyllactose (2′-FL) and 3-fucosyllactose (3-FL)—on the composition of infant ...
Krista Salli, Johanna Hirvonen, Heli Anglenius, Ashley A. Hibberd, Ilmari Ahonen, Markku T. Saarinen, Johanna Maukonen, Arthur C. Ouwehand   +7 more
doaj   +1 more source

The Impact of Oral‐Gut Microbiota Structure and Its Manipulation on RA Development and Management

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
(A) Schematic representation of oral–gut microbiota composition in health and rheumatoid arthritis (RA), highlighting the enrichment of beneficial microorganisms (green) under healthy conditions and the expansion of pathogenic microorganisms (orange) in RA‐associated dysbiosis.
Parisa Ahmadi, Mahmoud Mahmoudi, Sina Mozaffari‐Jovin, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Jafar Hajavi, Hanieh Kolahdooz, Seyed‐Alireza Esmaeili   +8 more
wiley   +1 more source

2′‐FL's Depiction of the Human Physiological Function Landscape

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The figure summarizes the multifaceted physiological effects of 2′‐fucosyllactose (2′‐FL), a major human milk oligosaccharide. The schematic illustrates the central role of the gut‐centered regulatory axis, where 2′‐FL modulates gut microbiota composition, promotes the production of short‐chain fatty acids and microbial metabolites, enhances mucus ...
Yushan Xiao, Jiahao Li, Xiaofeng Li, Yan Dai   +3 more
wiley   +1 more source

Maternal and infant gut microbiome

iMeta, Volume 5, Issue 4, August 2026.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Deciphering the differential effects of human milk oligosaccharides (HMOs) on infant and adult microbiota: insights from a novel “gut microbe-host interaction” model

Journal of Functional Foods
Human milk oligosaccharides (HMOs) modulate gut microbiota and intestinal barrier integrity; however, age-dependent microbiota-mediated effects remain insufficiently defined.
Xiaochen Chen, Luis Llanos Moreno, Luis Silva-Lagos, Henk A. Schols, Marthe T.C. Walvoort, Paul de Vos, Naschla Gasaly   +6 more
doaj   +1 more source

Mass Spectrometry and NMR Spectroscopy‐Based Structural Characterization of Polysaccharide From Gastrodia elata Blume

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Structural characterization of complex carbohydrates remains challenging. This study employed methylation, acid hydrolysis, 1‐phenyl‐3‐methyl‐5‐pyrazolone (PMP) derivatization, and ultra‐high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) to determine monosaccharides, glycosidic linkages, and sequence of ...
Hui Yan, Cheng‐Xi Feng, Zhe Wang, Jun‐Qiao Wang, Shao‐Ping Nie   +4 more
wiley   +1 more source

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 829-850, July/August 2026.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song, HyunJi Lee, Youngshik Choe, Hyeyoung Lee   +3 more
wiley   +1 more source

Human Milk Bioactive Compounds and Psychomotor Outcomes in Infants and Children: A Systematic Review

Molecular Nutrition &Food Research, Volume 70, Issue 14, 29 July 2026.
In our review, we assess the role of HM fatty acids, oligosaccharides, proteins, and carotenoids, on psychomotor development in children up to 18 years. Findings suggest that HM BCs, particularly n‐3 PUFAs and fucosylated HMOs, might contribute to a favorable psychomotor development in infancy, preschool age, and school age.
Lara Huber, Eduard Flores Ventura, Regina Ensenauer, Daria Guseva   +3 more
wiley   +1 more source

Alleviation of Intestinal Inflammation by Oral Supplementation With 2-Fucosyllactose in Mice [PDF]

, 2019
Milk oligosaccharides exert a prebiotic action that contributes to the development of the infant gut microbiota during lactation. Given that milk oligosaccharides remain intact after passage through stomach and small intestine, they can potentially ...
Hennet, Thierry, Garzon, Jesus Francisco Glaus, Geirnaert, Annelies; id_orcid, Hausmann, Martin, Geirnaert, Annelies, Lacroix, Christophe, Grabinger, Thomas, Glaus Garzon, Jesus Francisco, Lacroix, Christophe; id_orcid, Glaus Garzon JF, Hausmann M, Grabinger T, Geirnaert A, Hennet T, Lacroix C   +14 more
core   +1 more source