Results 101 to 110 of about 6,185 (114)

The endocannabinoid 2-arachidonoylglycerol regulates oligodendrocyte progenitor cell migration

Biochemical Pharmacology, 2018
While the endocannabinoid 2-arachidonoylglycerol (2-AG) is thought to enhance the proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) in vitro, less is known about how endogenous 2-AG may influence the migration of these cells.
Maria A, Sanchez-Rodriguez, Oscar, Gomez, Pedro F, Esteban, Daniel, Garcia-Ovejero, Eduardo, Molina-Holgado   +4 more
openaire   +2 more sources

Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy

Drug Discovery Today, 2014
The endocannabinoid system is implicated in, and regulates, several physiological processes, ranging from food intake and energy balance to pain and inflammation. 2-Arachidonoylglycerol (2-AG) is a full agonist at the cannabinoid receptors which classically mediate its effects. The activity of this bioactive lipid is dependent on its endogenous levels,
Mireille, Alhouayek, Julien, Masquelier, Giulio G, Muccioli   +2 more
openaire   +2 more sources

Endocannabinoids anandamide and 2- arachidonoylglycerol in sepsis

2021
BACKGROUND-AIM Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The incidence that continues to rise, high mortality and lack of early biomarkers to accurately identify disease processes, still represent a great challenge in sepsis diagnosis and treatment.
Šahinović, Ines, Mandić, Sanja, Duvnjak, Mario, Perić, Ljiljana, Šerić, Vatroslav, Mihić, Damir   +5 more
openaire   +2 more sources

2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor

European Journal of Pharmacology, 2001
We investigated whether 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, is involved in acetylcholine- and calcium ionophore A23187-induced relaxations in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME) and indomethacin, which is considered to be mediated by endothelium-derived hyperpolarizing factor (EDHF).
S, Kagota, Y, Yamaguchi, K, Nakamura, T, Sugiura, K, Waku, M, Kunitomo   +5 more
openaire   +2 more sources

Mass‐Spectrometric Identification of Anandamide and 2‐Arachidonoylglycerol in Nematodes

Chemistry & Biodiversity, 2008
AbstractThe purpose of the study was to see if nematodes (Caenorhabditis elegans, Caenorhabditis briggsae, and Pelodera strongyloides) produce endocannabinoids; i.e., anandamide (AEA) and 2‐arachidonoylglycerol (2‐AG). In this study, AEA and 2‐AG were identified as endogenous products from nematodes by using electrospray‐ionization ion‐trap MS/MS (ESI ...
Marko, Lehtonen, Kaja, Reisner, Seppo, Auriola, Garry, Wong, James C, Callaway   +4 more
openaire   +2 more sources

Detection of an Endogenous Cannabimimetic Molecule, 2-Arachidonoylglycerol, and Cannabinoid CB1 Receptor mRNA in Human Vascular Cells: Is 2-Arachidonoylglycerol a Possible Vasomodulator?

Biochemical and Biophysical Research Communications, 1998
Human vascular endothelial cells were found to generate and release 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, upon stimulation with thrombin or A23187. We confirmed that vascular smooth muscle cells as well as endothelial cells possess cannabinoid CB1 receptor mRNA.
T, Sugiura, T, Kodaka, S, Nakane, S, Kishimoto, S, Kondo, K, Waku   +5 more
openaire   +2 more sources

2-Arachidonoylglycerol

Lipidomics Gateway, 2010
Jean-Michel Scherrmann, Kim Wolff, Christine A. Franco, Marc N. Potenza, Tayfun Uzbay, Lisiane Bizarro, David C. S. Roberts, Robert L. Balster, Sharon L. Walsh, Barbara J. Mason, Charles J. Heyser, Anthony L. Riley, Steve Kohut, Marie-Louise G. Wadenberg, Heather Wilkins, Paul Newhouse, Anne Jackson, Joachim D. Uys, Peter W. Kalivas, Victoria L. Harvey, Tony Dickenson, Daniel Bertrand, Hans Rollema, Raymond S. Hurst, Gorkem Yararbas, Sakire Pogun, Marie-Louise G. Wadenberg, Debby Van Dam, Peter Paul De Deyn, Samuel G. Siris, Richard W. Foltin, Michael J. Kuhar, Robert L. Balster, Sharon L. Walsh, Robert L. Balster, Sharon L. Walsh, Michel Le Moal, Christoph Hiemke, Nicola Simola, Micaela Morelli, Nicola Simola, Micaela Morelli, Nicola Simola, Micaela Morelli, Alyson J. Bond, James J. Strain, R. Andrew Chambers, R. H. De Rijk, E. R. de Kloet, Bankole A. Johnson, Andreas Marneros, Suzanne H. Mitchell, Harriet de Wit, Mark Slifstein, Klaus A. Miczek, Rosa M. M. de Almeida, Emil F. Coccaro, David S. Baldwin, John Atack, Hilde Lavreysen, Rosa M. M. de Almeida, Klaus A. Miczek, Alyson J. Bond, Alfonso Abizaid, Shimon Amir, Samuel G. Siris, Joseph H. Friedman, Theodora Duka, Jelena Nesic, Falk Kiefer, Karl Mann, Bankole A. Johnson, Barbara J. Mason, Charles J. Heyser, Karl Mann, Falk Kiefer, Christopher L. Cunningham, Barbara J. Mason, Charles J. Heyser, Yesne Alici, William Breitbart, Subhash C. Pandey, Karl Mann, Falk Kiefer, Kieran O’Malley, Kieran O’Malley, Mitul A. Mehta, Linda Dykstra, John Atack, Hilde Lavreysen, Debby Van Dam, Peter Paul De Deyn, Holden D. Brown, Michael E. Ragozzino, Brian E. Leonard, Malcolm Lader, Peter J. Flor, Inga D. Neumann, Linda P. Spear, Holden D. Brown, Michael E. Ragozzino, Daniel Hoyer, Martina de Zwaan, Michael J. Owens, Chase H. Bourke, Philip J. Cowen, Pedro L. Delgado, Hiroyuki Uchida, Shitij Kapur, Harriet de Wit, Lawrence H. Price, Malcolm Lader, Husseini K. Manji, Jorge A. Quiroz, Seiya Miyamoto, Francisco Aboitiz, Ximena Carrasco, F. Xavier Castellanos, Michael J. Owens, Chase H. Bourke, Elizabeth C. Warburton, Husseini K. Manji, Jorge A. Quiroz, Linda Dykstra, James H. Woods, Mei-Chuan Ko, Gail Winger, Andrew Young, Jill B. Becker, Helen J. Cassaday, Paul Willner, Maria Isabel Colado, A. Richard Green, Marilyn E. Carroll, Peter A. Santi, Iván Izquierdo, Lia R. Bevilaqua, Martin Cammarota, Alfonso Abizaid, Shimon Amir, Jason C. G. Halford, Arthur Christopoulos, Gregory D. Stewart, Patrick M. Sexton, Sheldon Preskorn, Megan M. Dahmen, Jana Lincoln, Edoardo Spina, Brian E. Leonard, J. Craig Nelson, Meghan M. Grady, Stephen M. Stahl, Thomas R. E. Barnes, Michael M. Morgan, MacDonald J. Christie, Linda Dykstra, Joseph H. Friedman, Marie-Louise G. Wadenberg, Wiepke Cahn, Heleen B. M. Boos, H. D. Postma, Seiya Miyamoto, W. Wolfgang Fleischhacker, Samuel B. Hutton, Peter J. Flor, Inga D. Neumann, Inga D. Neumann, Peter J. Flor, Peter J. Flor, Inga D. Neumann, Grasielle C. Kincheski, Leandro J. Bertoglio, Antonio Pádua Carobrez, Helio Zangrossi, Frederico Guilherme Graeff, James Winslow, Yogita Chudasama, Paul Newhouse, Heather Wilkins, Naheed (Max) Mirza, Shuang Yu, Nuno Sousa, Osborne F. X. Almeida, Osborne F. X. Almeida, Nuno Sousa, Shuang Yu, Osborne F. X. Almeida, Nuno Sousa, Shuang Yu, Tim C. Kirkham, Tim C. Kirkham, Jason C. G. Halford, Ronald F. Mucha, Cecilia J. Hillard, Cecilia J. Hillard, Kim Wolff, Fiona Thomson, Susan Napier, Marie-Louise G. Wadenberg, Craig A. Erickson   +199 more
openaire   +2 more sources

Physiological roles of 2‐arachidonoylglycerol, an endogenous cannabinoid receptor ligand

BioFactors, 2009
Abstract2‐Arachidonoylglycerol is an arachidonic acid‐containing monoacylglycerol isolated from the rat brain and canine gut as an endogenous ligand for the cannabinoid receptors (CB1 and CB2). 2‐Arachidonoylglycerol binds to both the CB1 receptor, abundantly expressed in the nervous system, and the CB2 receptor, mainly expressed in the immune system ...
openaire   +2 more sources

2-Arachidonoylglycerol: An Endogenous Cannabinoid Receptor Agonist

2000
T, Sugiura, K, Waku
openaire   +2 more sources

2-Arachidonoylglycerol in Cardiovascular Disease: Angel or Demon?

Cardiovascular Drugs and Therapy, 2022
Jinzhen Cui, Qiuxia Zhang, Yuguang Fan
openaire   +2 more sources