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Endocannabinoid 2-arachidonoylglycerol is elevated in the coronary circulation during acute coronary syndrome. [PDF]
PLoS One, 2019 Jehle J +5 more
europepmc +1 more source
Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior. [PDF]
Biol Psychiatry, 2018 Shonesy BC +15 more
europepmc +1 more source
A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation [PDF]
Chemistry and Physics of Lipids, 2002 2-Arachidonoylglycerol (2-AG) is a naturally occurring monoglyceride that activates cannabinoid receptors and meets several key requisites of an endogenous cannabinoid substance. It is present in the brain (where its levels are 170-folds higher than those of anandamide), is produced by neurons in an activity- and calcium-dependent manner, and is ...
Tamás F Freund, Daniele Piomelli
exaly +7 more sources
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2-Arachidonoylglycerol and the cannabinoid receptors
Chemistry and Physics of Lipids, 20002-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated from rat brain and canine gut as an endogenous cannabinoid receptor ligand (Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., Waku, K., 1995.
Takayuki Sugiura, Keizo Waku
exaly +3 more sources
Biosynthesis and degradation of the endocannabinoid 2‐arachidonoylglycerol
BioFactors, 2010Abstract2‐Arachidonoylglycerol (2‐AG) is a monoacylglycerol (MAG) molecule containing an esterified arachidonic acid chain at sn‐2 position of the glycerol backbone. Together with structurally similar N‐arachidonoylethanolamine (anandamide), 2‐AG has been extensively studied as an endogenous ligand of cannabinoid receptors (an endocannabinoid) in brain
Natsuo, Ueda +3 more
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The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair
International Journal of Cardiology, 2021Endothelial dysfunction promotes atherogenesis, vascular inflammation, and thrombus formation. Reendothelialization after angioplasty is required in order to prevent stent failure. Previous studies have highlighted the role of 2-arachidonoylglycerol (2-AG) in murine experimental atherogenesis and in human coronary artery disease. However, the impact of
Julian, Jehle +9 more
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2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor
European Journal of Pharmacology, 2001We investigated whether 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, is involved in acetylcholine- and calcium ionophore A23187-induced relaxations in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME) and indomethacin, which is considered to be mediated by endothelium-derived hyperpolarizing factor (EDHF).
Satomi Kagota +2 more
exaly +3 more sources
Monoglyceride Lipase as an Enzyme Hydrolyzing 2‐Arachidonoylglycerol
Chemistry & Biodiversity, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Susanna M, Saario, Jarmo T, Laitinen
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An improved method for the synthesis of 2-arachidonoylglycerol
Process Biochemistry, 2014Abstract 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist for cannabinoid receptors and has exhibited various biological activities. In this study, we reported an improved method for the synthesis of 2-AG by enzymatic ethanolysis of arachidonic acid-rich oil.
Xiaosan Wang +4 more
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