2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress. [PDF]
Metabolites, 2021 Cholesterol metabolism affects endoplasmic reticulum (ER) stress and modulates epithelial-mesenchymal transition (EMT). Our previous study demonstrated that 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) attenuated EMT by blocking the transforming growth ...
Zhao Y, He L, Wang T, Zhu L, Yan N.
europepmc +2 more sources
Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation. [PDF]
Pharmaceuticals (Basel), 2020 α-Mangostin (α-M), one of the active compounds in Garcinia mangostana peel, has been effectively used in wound healing. However, its poor solubility in aqueous solution causes low bioavailability for skin ulcers, hindering its application in wound ...
Wathoni N +7 more
europepmc +2 more sources
A phase 1/2 open label nonrandomized clinical trial of intravenous 2-hydroxypropyl-β-cyclodextrin for acute liver disease in infants with Niemann-Pick C1. [PDF]
Mol Genet Metab Rep, 2021 Introduction Niemann-Pick C (NPC) is an autosomal recessive disease due to defective NPC1 or NPC2 proteins resulting in endo-lysosomal storage of unesterified cholesterol in the central nervous system and liver.
Reynolds M +12 more
europepmc +2 more sources
Applied Sciences, 2023 Studies of polyphenols in various natural products have shown their variability and often low amounts. Thus, we aimed to investigate the bioaccessibility of the main polyphenolic groups extracted from two poplar types of propolis collected in continental
Eleonora Perak Junaković +9 more
semanticscholar +1 more source
Thymoquinone: Hydroxypropyl-β-cyclodextrin Loaded Bacterial Cellulose for the Management of Wounds
Pharmaceutics, 2022 The need for more advantageous and pharmaceutically active wound dressings is a pressing matter in the area of wound management. In this study, we explore the possibility of incorporating thymoquinone within bacterial cellulose, utilising cyclodextrins ...
Sam Swingler +6 more
doaj +1 more source
The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin [PDF]
Hemijska Industrija, 2015 The aim of this work was the preparation of the inclusion complex of naproxen with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) in order to improve the physical and chemical properties of naproxen.
Ilić-Stojanović Snežana S. +6 more
doaj +1 more source
Pharmaceutics, 2023 The biopharmaceutical classification system groups low-solubility drugs into two groups: II and IV, with high and low permeability, respectively. Most of the new drugs developed for common pathologies present solubility issues.
María Elena Gamboa-Arancibia +6 more
doaj +1 more source
Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]
, 2018 Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni +8 more
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning ...
Anna Stasiłowicz +9 more
doaj +1 more source
Buccal Resveratrol Delivery System as a Potential New Concept for the Periodontitis Treatment
Pharmaceutics, 2021 The health benefits of resveratrol have been proven to inhibit the development of numerous diseases. A frequent limitation in its use is a low bioavailability stemming from a poor solubility and fast enterohepatic metabolism.
Magdalena Paczkowska-Walendowska +7 more
doaj +1 more source