Results 21 to 30 of about 9,813 (135)

Interactions between 4-thiothymidine and water-soluble cyclodextrins: Evidence for supramolecular structures in aqueous solutions

Beilstein Journal of Organic Chemistry, 2016
Since several years the inclusion of organic compounds (guests) within the hydrophobic cavity (host) of cyclodextrins (CDs) has been the subject of many investigations.
Vito Rizzi, Sergio Matera, Paola Semeraro, Paola Fini, Pinalysa Cosma   +4 more
doaj   +1 more source

Preparation, Characterization and Molecular Dynamics Simulation of Rutin–Cyclodextrin Inclusion Complexes

Molecules, 2023
Rutin is a natural flavonoid that carries out a variety of biological activities, but its application in medicine and food is limited by its water solubility.
Chaokang Chang, Meng Song, Mingxing Ma, Jihong Song, Fengyi Cao, Qi Qin   +5 more
doaj   +1 more source

Characterization of an aryl piperazine/2-hydroxypropyl-β-cyclodextrin association, a complex with antidiabetic potential

Results in Chemistry, 2020
This study explores the molecular association between 4-(thiophen-2-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)butan-1-one (RTC1), an antidiabetic compound recently reported by our research group with challenging aqueous solubility, and 2 ...
R. Devine, D.S.D. Martin, G.K. Kinsella, J.B.C. Findlay, J.C. Stephens   +4 more
doaj   +1 more source

Nano-Spray-Dried Levocetirizine Dihydrochloride with Mucoadhesive Carriers and Cyclodextrins for Nasal Administration

Pharmaceutics, 2023
Antihistamines such as levocetirizine dihydrochloride (LC) are commercially used in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray-dried using three mucoadhesive polymers and four cyclodextrin species to form ...
Mirella Mirankó, Judit Tóth, Csilla Bartos, Rita Ambrus, Tivadar Feczkó   +4 more
doaj   +1 more source

Enhancement of norfloxacin solubility via inclusion complexation with β-cyclodextrin and its derivative hydroxypropyl-β-cyclodextrin

Asian Journal of Pharmaceutical Sciences, 2016
The objectives of the study were to investigate the effects of β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility and dissolution rate of norfloxacin prepared using three different methods, at drug to cyclodextrin weight ...
Gabriel Onn Kit Loh, Yvonne Tze Fung Tan, Kok-Khiang Peh   +2 more
doaj   +1 more source

Solubility enhancement of etoricoxib using inclusion complexation with cyclodextrins: formulation of oro dispersible tablets by QbD approach

Journal of Applied Pharmaceutical Research
Background: The work was intended to enhance etoricoxib's solubility and dissolution rate and then develop oro-dispersible tablets for faster onset of action. Methodology: Inclusion complexes (ICs) of the drug were obtained with β-cyclodextrin (β-CD) and
Anjan Kumar Mahapatra, Siddharth Dora, Sanatan Parida, Usharani Bal, Bandana Rani Jena, Madhusmita Lenka   +5 more
doaj   +1 more source

Maternal and Foetal Cardiovascular Effects of the Anaesthetic Alfaxalone in 2-Hydroxypropyl-β-cyclodextrin in the Pregnant Ewe

The Scientific World Journal, 2013
The objective of this study was to determine the pharmacodynamics effects of the anaesthetic alfaxalone in 2-hydroxypropyl-β-cyclodextrin in pregnant sheep after the intravenous injection of a 2 mg/kg weight dose.
Anna Andaluz, Laura Santos, Félix García, Rosa I. Ferrer, Laura Fresno, Xavier Moll   +5 more
doaj   +1 more source

Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-β-cyclodextrin: A biosensor evaluation and interaction study

Asian Journal of Pharmaceutical Sciences, 2020
The bitterness of a drug is a major challenge for patient acceptability and compliance, especially for children. Due to the toxicity of medication, a human taste panel test has certain limitations.
Shuying Li, Ying Zhang, Abdur Rauf Khan, Shuwang He, Yingxin Wang, Jiangkang Xu, Guangxi Zhai   +6 more
doaj   +1 more source

Preservation of Aroma in Rougui Oolong Tea by Hydroxypropyl-β-cyclodextrin

Shipin gongye ke-ji
Oolong tea was highly favored by consumers for its rich aroma. However, there was significant loss of fragrance in Oolong tea products during processing and storage, urgently necessitating the development of corresponding technologies to stabilize aroma ...
Yanqun XU, Jing HUANG, Ziqing WU, Nanfeng TAN, Jiayi XU, Jia CHEN, Tian YE, Gennü WANG, Dan LONG, Yongquan XU, Zisheng LUO   +10 more
doaj   +1 more source

Modulation of Distribution and Diffusion through the Lipophilic Membrane with Cyclodextrins Exemplified by a Model Pyridinecarboxamide Derivative

Pharmaceutics, 2023
The main aims of the study were to disclose the influence of the structure on the solubility, distribution and permeability of the parent substances, iproniazid (IPN), isoniazid (INZ) and isonicotinamide (iNCT), at 310.2 K and to evaluate how the ...
Tatyana Volkova, Olga Simonova, German Perlovich   +2 more
doaj   +1 more source