Results 31 to 40 of about 10,839 (246)

Diversity-oriented functionalization of 2-pyridones and uracils

Nature Communications, 2021
Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of ...
Yong Shang, Chenggui Wu, Qianwen Gao, Chang Liu, Lisha Li, Xinping Zhang, Hong-Gang Cheng, Shanshan Liu, Qianghui Zhou   +8 more
doaj   +1 more source

Characterization studies of 1-(4-cyano-2-oxo-1,2-dihydro-1-pyridyl)-3-(4-cyano-1,2-dihydro-1-pyridyl)propane formed from the reaction of hydroxide Ion with 1,3-Bis-(4-cyano pyridinium)propane [PDF]

, 2011
The aqueous alkaline reaction of 1,3-bis(4-cyanopyridinium)propane dibromide, a reactant constituted of two pyridinium rings linked by a three-methylene bridge, generates a novel compound,1 -(4-cyano-2-oxo-1,2-dihydro-1-pyridyl)-3-(4-cyano-1,2-dihydro-1 ...
CATALANI, Luiz H, CHAIMOVICH, Hernan, FIORI, Simone, HIOKA, Noboru, MEYER, Emerson, POLITI, Mário J, SCHUQUEL, Ivânia T. A, SILVA, Idélcio N. da   +7 more
core   +1 more source

Ribonucleotide reductase, a novel drug target for gonorrhea

eLife, 2022
Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum ...
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom   +15 more
doaj   +1 more source

6-Methyl-2-pyridone pentahydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2004
Crystals of the title compound, C6H7NO·5H2O, were grown over a period of several weeks from an aqueous solution of the commercial compound. The mol­ecule crystallizes in space group P\overline 1 and there are two independent 6-methyl-2-pyridone (Hmhp) mol­ecules in the asymmetric unit, together with ten mol­ecules of water.
Clegg W, Nichol GS
openaire   +2 more sources

Synthesis of 2-Aryl-5-Nitropyridines by Three-Component Ring Transformation of 3,5-Dinitro-2-Pyridone [PDF]

, 2014
2-Arylated-5-nitropyridines were efficiently synthesized by a three-component ring transformation of 3,5-dinitro-2-pyridone with aromatic ketones in the presence of ammonium acetate, in which the dinitropyridone serves as a synthetic equivalent of an ...
1310, 1311, 1312, 1313, 1314, 1315, Asahara, Haruyasu, Kobiro, Kazuya, Le, Thi Song, Nishiwaki, Nagatoshi, Saigo, Kazuhiko, Sugimoto, Ryuichi   +11 more
core   +1 more source

catena-Poly[[[(2-pyridone-κO)silver(I)]-μ-2-pyridone-κ2O:O] hexafluoridophosphate]

Acta Crystallographica Section E, 2010
The asymmetric unit of the polymeric title salt, {[Ag(C5H5NO)2]PF6}n, comprises an AgI cation (located on a twofold axis), two 2-pyridone ligands (with distinct coordination modes), and half a PF6− anion (situated on a centre of inversion). The
Edward R. T. Tiekink, Tyler Miller, Hadi D. Arman   +2 more
doaj   +1 more source

Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches

mBio, 2021
Diverse 2-pyridone alkaloids have been identified with an array of biological and pharmaceutical activities, including the development of drugs. However, the biosynthetic regulation and chemical ecology of 2-pyridones remain largely elusive.
Bo Chen, Yanlei Sun, Shiqin Li, Ying Yin, Chengshu Wang   +4 more
doaj   +1 more source

Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Kane A. C. Bastick, Caleb E. Griesbach, Ben Zhen Huang, Morgan J. Cordell, Yang (Daniel) Ou, Alán Aspuru‐Guzik, Andrei K. Yudin   +6 more
wiley   +2 more sources

Synthesis of New Aza-Heterocyclic Based on 2-Pyridone

Chemistry Proceedings
In this work, we present new methods of synthesis of different molecules including a 2-pyridone nucleus. First, we prepared a series of 1H-free 2-pyridones and N-alkyl 2-pyridones from ethyl cyanoacetate, aromatic aldehydes, various acetophenone ...
Ikram Baba-Ahmed, Zahira Kibou, Julio A. Seijas, Noureddine Choukchou-Braham, M. Pilar Vázquez-Tato   +4 more
doaj   +1 more source

Supramolecular Potential of Vanadium β-Diketonate and Picolinate Compounds and The First One-dimensional Oxidovanadium(IV) Complex with β-Diketonate Ligand

Acta Chimica Slovenica, 2014
Three vanadium compounds with β-diketonato or picolinato ligands were prepared and structurally characterized. In compounds [VO(tfpb)2]∞ (1) (tfpb = 4,4,4-trifluoro-1-phenylbutane-1,3-dionate) and [VO(acac)2(2-pyridone)] (2) the coordination of vanadium ...
Tanja Koleša Dobravc, Anton Meden, Franc Perdih   +2 more
doaj   +1 more source