Results 31 to 40 of about 10,272 (249)
Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds
Journal of Saudi Chemical Society, 2021 Background: The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance.
Mostafa M.K. Amer +4 more
doaj
SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. [PDF]
, 2017 Pericyclic reactions-which proceed in a concerted fashion through a cyclic transition state-are among the most powerful synthetic transformations used to make multiple regioselective and stereoselective carbon-carbon bonds.
Chen, Mengbin +9 more
core +1 more source
Angewandte Chemie, EarlyView.Chemoselectivity Challenge: A precise catalyst design allows for chemoselectivity control over alkyne reactivity to yield pentafulvenes via (2 + 2 + 1) cyclotrimerization. Operative mechanism has been elucidated by means of stoichiometric and deuteration experiments, as well as DFT calculations.
Belinda Español‐Sánchez +6 more
wiley +2 more sources
Maternal Circulatory NAD Precursor Levels and the Yolk Sac Determine NAD Deficiency-Driven Congenital Malformation Risk. [PDF]
FASEB JMaternal circulatory L‐tryptophan (TRP) and nicotinamide (NAM) levels are proportional to dietary TRP intake. Yolk sacs, but not embryos, perform NAD de novo synthesis. This study explores the exchange of NAD precursors between mother and conceptus, and NAD generation in conceptal tissues via the NAD de novo synthesis (blue) or salvage (red) pathways ...
Bozon K +6 more
europepmc +2 more sources
Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]
, 2014 Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chen, Chao-Yin +3 more
core +3 more sources
Angewandte Chemie, EarlyView.N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina +10 more
wiley +2 more sources
Ribonucleotide reductase, a novel drug target for gonorrhea
eLife, 2022 Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum ...
Jana Narasimhan +15 more
doaj +1 more source
Synthesis of (−)-epibatidine [PDF]
, 2014 An asymmetric synthesis to the dendrobatid alkaloid (−)-epibatidine has been described, featuring chiral resolution of both optically pure 7-azabicyclo[2.2.1]heptanecarboxylic acid, and subsequent transformations to (−)-epibatidine.
Chiang, Yu-Min, Chiou, Wen-Hua
core +1 more source
Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case Control Study [PDF]
, 2001 This work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders.
Sílvia O. Diaz +13 more
core +3 more sources
Synthesis of New Aza-Heterocyclic Based on 2-Pyridone
Chemistry ProceedingsIn this work, we present new methods of synthesis of different molecules including a 2-pyridone nucleus. First, we prepared a series of 1H-free 2-pyridones and N-alkyl 2-pyridones from ethyl cyanoacetate, aromatic aldehydes, various acetophenone ...
Ikram Baba-Ahmed +4 more
doaj +1 more source