Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death [PDF]
Redox Biology, 2014 Lipid peroxidation products have been known to induce cellular adaptive responses and enhance tolerance against subsequent oxidative stress through up-regulation of antioxidant compounds and enzymes.
Akishi Okabe +7 more
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Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation [PDF]
International Journal of Molecular Sciences, 2020 Oxysterols, important regulators of cholesterol homeostasis in the brain, are affected by neurodegenerative diseases. Early-onset Alzheimer’s disease is associated with higher levels of circulating brain-derived 24S-hydroxycholesterol (24S-OHC ...
Kazutake Hirooka, Hiroshi Matsuoka
exaly +3 more sources
Journal of Lipid Research, 2004 24S-Hydroxycholesterol (24S-OH-Chol) and 27-hydroxycholesterol (27-OH-Chol) are oxidized derivatives of cholesterol and of potential diagnostic interest because their circulating levels may reflect the cholesterol metabolism of the brain and macrophages,
Ines Burkard +2 more
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Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients [PDF]
Journal of Lipid Research, 2000 Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane cholesterol release.
Dieter Lütjohann +10 more
doaj +2 more sources
Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study [PDF]
BMC Neurology, 2011 Background In central nervous system cholesterol cannot be degraded but is secreted into circulation predominantly in the form of its polar metabolite 24(S)-hydroxycholesterol (24S-OH-Chol).
Bonetti Francesco +8 more
doaj +3 more sources
Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice. [PDF]
J Cereb Blood Flow Metab, 2021 The major pathway of brain cholesterol turnover relies on its hydroxylation into 24S-hydroxycholesterol (24S-HC) using brain-specific cytochrome P450 46A1 (CYP46A1).
Lu F +5 more
europepmc +2 more sources
Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons [PDF]
Neuropharmacology, 2019 Xiaofei Wei +2 more
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Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine [PDF]
Alzheimer’s Research & TherapyBackground Oxysterols, gut metabolites, and N6-methyladenosine (m6A) are extensively implicated in the pathogenesis of cognitive dysfunction, while their alterations in different stages of mild cognitive impairment (MCI) have not been elucidated ...
Wenjing Feng +9 more
doaj +2 more sources
Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism [PDF]
JCI InsightPrion diseases are fatal, infectious, and incurable neurodegenerative conditions affecting humans and animals, caused by the misfolding of the cellular prion protein (PrPC) into its pathogenic isoform, PrPSc. In humans, sporadic Creutzfeldt-Jakob disease
Tahir Ali +5 more
doaj +2 more sources
Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices
Journal of Neurophysiology, 2016 Yukitoshi Izumi +2 more
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