Results 11 to 20 of about 9,716 (212)

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression [PDF]

Neurobiology of Disease, 2013
24S-hydroxycholesterol (24OHC) is involved in the conversion of excess cholesterol in the brain, and its level in plasma is related to the number of metabolically active neuronal cells.
Valerio Leoni, Jeffrey D. Long, James A. Mills, Stefano Di Donato, Jane S. Paulsen   +4 more
doaj   +7 more sources

Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia. [PDF]

NPJ Schizophr, 2020
Plasma 24S-hydroxycholesterol mostly originates in brain tissue and likely reflects the turnover of cholesterol in the central nervous system. As cholesterol is disproportionally enriched in many key brain structures, 24S-hydroxycholesterol is a ...
Chiappelli J, Quinton MS, Volfson D, Cwik M, Marshall W, Bruce H, Goldwaser E, Kvarta M, Summerfelt A, Kochunov P, O'Donnell P, Hong LE.   +11 more
europepmc   +5 more sources

24S‐hydroxycholesterol: cellular effects and variations in brain diseases [PDF]

Journal of Neurochemistry, 2020
The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or 24-cholesterol hydroxylase, that ...
Boussicault L., Bretillon L., Camargo N., Djelti F., Fellows Maxwell K., Freemantle E., Gambert S., Horton J. D., Huber M., Hughes T. M., Kotti T., Kraats C., Kölsch H., Locatelli S., Lütjohann D., Okabe A., Saint‐Pol J., Ullrich C., Valenza M., Wang Y.   +19 more
core   +7 more sources

Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke. [PDF]

Stroke
BACKGROUND: For several decades, it has been recognized that overactivation of the glutamate-gated N-methyl-D-aspartate receptors (NMDARs) and subsequent Ca2+ toxicity play a critical role in ischemic brain injury.
Sun H, Yang T, Simon RP, Xiong ZG, Leng T.   +4 more
europepmc   +5 more sources

Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. [PDF]

BMC Neurosci, 2014
BackgroundCholesterol metabolism is important for the maintenance of myelin and neuronal membranes in the central nervous system. Blood concentrations of the brain specific cholesterol metabolite 24S-hydroxysterol to the peripheral metabolite 27 ...
Bandaru VV, Haughey NJ.
europepmc   +5 more sources

Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes. [PDF]

Front Aging Neurosci, 2021
Background Abnormal cholesterol metabolism is common in type 2 diabetes mellitus (T2DM) and causes dementia. Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol (24-OHC) and maintains cholesterol homeostasis in the ...
Shi J, Jia J, Tian S, Zhang H, An K, Zhu W, Cao W, Yuan Y, Wang S.   +8 more
europepmc   +2 more sources

Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death [PDF]

Redox Biology, 2014
Lipid peroxidation products have been known to induce cellular adaptive responses and enhance tolerance against subsequent oxidative stress through up-regulation of antioxidant compounds and enzymes.
Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, Noriko Noguchi   +7 more
doaj   +3 more sources

24S-Hydroxycholesterol: A potential brain-derived biomarker of Huntington’s Disease

medRxiv
Abstract Huntington’s disease (HD) arises from of an expanded polyglutamine-coding trinucleotide repeat in exon 1 of the huntingtin gene. Despite considerable research, a successful disease modifying therapy has yet to be confirmed. Cholesterol homeostasis in brain is considered one of the biological processes to be disturbed in HD.
Asgari MA, Langbehn DR, Skibinski DOF, Lee R, Griffiths WJ, Wang Y.   +5 more
europepmc   +3 more sources

Metabolic labeling kinetics of brain-derived 24S-hydroxycholesterol in blood in multiple sclerosis: Effects of treatment with the remyelinating antibody rHIgM22. [PDF]

Mult Scler J Exp Transl Clin
Background Cholesterol is an essential and major component of myelin. Brain cholesterol turnover in humans can be studied noninvasively by metabolic labeling of the brain-specific cholesterol metabolite, 24S-hydroxycholesterol (24-OHC), which is released
Shankaran M, Li KW, Mohammed HA, Protasio J, Fitch M, Matthews M, Nyangau E, Smith G, Klein S, Eisen A, Turner S, Hellerstein MK.   +11 more
europepmc   +2 more sources

Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices

Journal of Neurophysiology, 2016
Min-Yu Sun, Yukitoshi Izumi, Charles F Zorumski   +2 more
exaly   +3 more sources