24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A) [PDF]
Journal of Lipid Research, 2000 (24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin +3 more
doaj +3 more sources
Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients [PDF]
Journal of Lipid Research, 2000 Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane cholesterol release.
Dieter Lütjohann +10 more
doaj +3 more sources
Liver X Receptor α (LXRα) Regulates 5β-Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism. [PDF]
J Exp Zool A Ecol Integr PhysiolABSTRACT Steroid‐mediated maternal effects are well‐studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure.
Paitz RT +4 more
europepmc +2 more sources
Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases [PDF]
MetabolitesAlthough the brain comprises only 2% of total body weight, it contains approximately 23% of the total cholesterol of the body. In the brain, cholesterol plays a critical role as a structural component of cell membranes and myelin sheaths.
Yoshimitsu Kiriyama +4 more
doaj +2 more sources
Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death [PDF]
Redox Biology, 2014 Lipid peroxidation products have been known to induce cellular adaptive responses and enhance tolerance against subsequent oxidative stress through up-regulation of antioxidant compounds and enzymes.
Akishi Okabe +7 more
doaj +2 more sources
Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia. [PDF]
NPJ Schizophr, 2020 AbstractPlasma 24S-hydroxycholesterol mostly originates in brain tissue and likely reflects the turnover of cholesterol in the central nervous system. As cholesterol is disproportionally enriched in many key brain structures, 24S-hydroxycholesterol is a promising biomarker for psychiatric and neurologic disorders that impact brain structure.
Chiappelli J +11 more
europepmc +4 more sources
Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine [PDF]
Alzheimer’s Research & TherapyBackground Oxysterols, gut metabolites, and N6-methyladenosine (m6A) are extensively implicated in the pathogenesis of cognitive dysfunction, while their alterations in different stages of mild cognitive impairment (MCI) have not been elucidated ...
Wenjing Feng +9 more
doaj +2 more sources
Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons [PDF]
Neuropharmacology, 2019 Cui Wei +2 more
exaly +2 more sources
Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation [PDF]
International Journal of Molecular Sciences, 2020 Hiroshi Matsuoka +2 more
exaly +2 more sources
Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism [PDF]
JCI InsightPrion diseases are fatal, infectious, and incurable neurodegenerative conditions affecting humans and animals, caused by the misfolding of the cellular prion protein (PrPC) into its pathogenic isoform, PrPSc. In humans, sporadic Creutzfeldt-Jakob disease
Tahir Ali +5 more
doaj +2 more sources