Results 21 to 30 of about 1,152 (159)

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Oxysterols promote tumor growth directly or through the dampening of tumor-infiltrating immune cells. Whether oxysterols contribute to pancreatic neuroendocrine tumor (pNET) development and how they are generated within the pNET microenvironment are currently unknown.
Soncini, Matias, Corna, Gianfranca, Moresco, Marta, Coltella, Nadia, Restuccia, Umberto, Maggioni, Daniela, Raccosta, Laura, Lin, Chin Yo, Invernizzi, Francesca, Crocchiolo, Roberto, DOGLIONI, CLAUDIO, Traversari, Catia, Bachi, Angela, Bernardi, Rosa, BORDIGNON, CLAUDIO, Gustafsson, Jan Ã…ke, Russo, Vincenzo   +16 more
openaire   +3 more sources

24S‐hydroxycholesterol: Cellular effects and variations in brain diseases [PDF]

Journal of Neurochemistry, 2020
AbstractThe adult brain exhibits a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme cytochrome P450 46A1 (CYP46A1) or 24‐cholesterol hydroxylase, that transforms cholesterol into 24S‐hydroxycholesterol (24S‐HC).
openaire   +4 more sources

Ventriculoperitoneal Shunt Treatment Increases 7 Alpha Hy-Droxy-3-Oxo-4-Cholestenoic Acid and 24-Hydroxycholesterol Concentrations in Idiopathic Normal Pressure Hydrocephalus

Brain Sciences, 2022
Idiopathic normal pressure hydrocephalus (iNPH) is the most common form of hydrocephalus in the adult population, and is often treated with cerebrospinal fluid (CSF) drainage using a ventriculoperitoneal (VP) shunt.
Emanuele Porru, Erik Edström, Lisa Arvidsson, Adrian Elmi-Terander, Alexander Fletcher-Sandersjöö, Anita Lövgren Sandblom, Magnus Hansson, Frida Duell, Ingemar Björkhem   +8 more
doaj   +1 more source

Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices

Journal of Neurophysiology, 2016
Min-Yu Sun, Yukitoshi Izumi, Ann Benz
exaly   +2 more sources

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Journal of Lipid Research, 1998
We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol in the human body and that there is a net flux of this steroid from the brain into the circulation (Lütjohann, D. et al. 1996. Proc. Natl. Acad. Sci. USA. 93:
Ingemar Björkhem, Dieter Lütjohann, Ulf Diczfalusy, Lars Ståhle, Gunvor Ahlborg, John Wahren   +5 more
doaj   +1 more source

Expression Cloning of an Oxysterol 7α-Hydroxylase Selective for 24-Hydroxycholesterol [PDF]

Journal of Biological Chemistry, 2000
The synthesis of 7alpha-hydroxylated bile acids from oxysterols requires an oxysterol 7alpha-hydroxylase encoded by the Cyp7b1 locus. As expected, mice deficient in this enzyme have elevated plasma and tissue levels of 25- and 27-hydroxycholesterol; however, levels of another major oxysterol, 24-hydroxycholesterol, are not increased in these mice ...
J, Li-Hawkins, E G, Lund, A D, Bronson, D W, Russell   +3 more
openaire   +2 more sources

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol

Journal of Lipid Research, 2001
Infants with the cholesterol synthesis defect Smith-Lemli-Opitz syndrome (SLO) have reduced activity of the enzyme 7-dehydrocholesterol-7-reductase and accumulate 7-dehydrocholesterol, with the highest concentration in the brain.
Ingemar Björkhem, Lena Starck, Ulla Andersson, Dieter Lütjohann, Sara von Bahr, Irina Pikuleva, Amir Babiker, Ulf Diczfalusy   +7 more
doaj   +1 more source

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols[S]

Journal of Lipid Research, 2014
Iso-octyl chain-hydroxylated oxysterols were determined in attomoles per 10,000 cells concentrations in 10,000–80,000 cultured pancreatic adenocarcinoma cells, using a sensitive, highly automated nano-LC-ESI-MS-based method.
Hanne Roberg-Larsen, Kaja Lund, Tore Vehus, Nina Solberg, Caroline Vesterdal, Dorna Misaghian, Petter Angell Olsen, Stefan Krauss, Steven Ray Wilson, Elsa Lundanes   +9 more
doaj   +1 more source

Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism

Cell Death Discovery, 2022
Perturbation of proteostasis triggers the adaptive responses that contribute to the homeostatic pro-survival response, whereas disruption of proteostasis can ultimately lead to cell death. Brain-specific oxysterol—i.e., 24(S)-hydroxycholesterol (24S-OHC)—
Yasuomi Urano, Shoya Osaki, Ren Chiba, Noriko Noguchi   +3 more
doaj   +1 more source