Results 21 to 30 of about 9,716 (212)

24S-Hydroxycholesterol Is Associated with Agitation Severity in Patients with Moderate-to-Severe Alzheimer's Disease: Analyses from a Clinical Trial with Nabilone. [PDF]

J Alzheimers Dis, 2019
Background: Agitation is a prevalent and difficult-to-treat symptom of Alzheimer’s disease (AD). The endocannabinoid system (ECS) has been a target of interest for the treatment of agitation. However, ECS signaling may interact with AD-related changes in
Ruthirakuhan M, Herrmann N, Andreazza AC, Verhoeff NPLG, Gallagher D, Black SE, Kiss A, Lanctôt KL.   +7 more
europepmc   +2 more sources

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A) [PDF]

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +3 more sources

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1 [PDF]

Journal of Lipid Research, 2013
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem   +9 more
doaj   +3 more sources

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

Journal of Lipid Research, 2000
We have previously presented evidence that most of the 24S-hydroxycholesterol present in the circulation originates from the brain and that most of the elimination of this oxysterol occurs in the liver.
Dieter Lütjohann, Ulf Diczfalusy, Ingemar Björkhem   +2 more
exaly   +3 more sources

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients [PDF]

Journal of Lipid Research, 2000
Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane cholesterol release.
Dieter Lütjohann, Andreas Papassotiropoulos, Ingemar Björkhem, Sandra Locatelli, Metin Bagli, Randi D. Oehring, Uwe Schlegel, Frank Jessen, Marie Luise Rao, Klaus von Bergmann, Reinhard Heun   +10 more
doaj   +4 more sources

Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases [PDF]

Metabolites
Although the brain comprises only 2% of total body weight, it contains approximately 23% of the total cholesterol of the body. In the brain, cholesterol plays a critical role as a structural component of cell membranes and myelin sheaths.
Yoshimitsu Kiriyama, Akira Nakatsuma, Hiroshi Tokumaru, Hisayo Sadamoto, Hiromi Nochi   +4 more
doaj   +2 more sources

Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine [PDF]

Alzheimer’s Research & Therapy
Background Oxysterols, gut metabolites, and N6-methyladenosine (m6A) are extensively implicated in the pathogenesis of cognitive dysfunction, while their alterations in different stages of mild cognitive impairment (MCI) have not been elucidated ...
Wenjing Feng, Mengwei Ju, Tao Wang, Shanshan Cui, Kexin Yang, Zhiting Guo, Miao Liu, Jiaxuan Tao, Huiyan Yu, Rong Xiao   +9 more
doaj   +2 more sources

Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism [PDF]

JCI Insight
Prion diseases are fatal, infectious, and incurable neurodegenerative conditions affecting humans and animals, caused by the misfolding of the cellular prion protein (PrPC) into its pathogenic isoform, PrPSc. In humans, sporadic Creutzfeldt-Jakob disease
Tahir Ali, Jessica Cashion, Samia Hannaoui, Hanaa Ahmed-Hassan, Hermann Schatzl, Sabine Gilch   +5 more
doaj   +2 more sources

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Oxysterols promote tumor growth directly or through the dampening of tumor-infiltrating immune cells. Whether oxysterols contribute to pancreatic neuroendocrine tumor (pNET) development and how they are generated within the pNET microenvironment are currently unknown.
Soncini, Matias, Corna, Gianfranca, Moresco, Marta, Coltella, Nadia, Restuccia, Umberto, Maggioni, Daniela, Raccosta, Laura, Lin, Chin Yo, Invernizzi, Francesca, Crocchiolo, Roberto, DOGLIONI, CLAUDIO, Traversari, Catia, Bachi, Angela, Bernardi, Rosa, BORDIGNON, CLAUDIO, Gustafsson, Jan Ã…ke, Russo, Vincenzo   +16 more
openaire   +3 more sources

Anti‐PCSK 9 antibodies increase the ratios of the brain‐specific oxysterol 24S‐hydroxycholesterol to cholesterol and to 27‐hydroxycholesterol in the serum

British Journal of Clinical Pharmacology, 2021
The serum ratios of the brain‐specific oxysterol 24S‐hydroxycholesterol (24S‐OHC) to cholesterol and to 27‐OHC reflect brain cholesterol turnover. We studied the effect of proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK9ab) that
D. Lütjohann, F. Stellaard, Bediha Bölükbasi, A. Kerksiek, K. Parhofer, U. Laufs   +5 more
semanticscholar   +1 more source