Results 21 to 30 of about 6,427 (151)

Ventriculoperitoneal Shunt Treatment Increases 7 Alpha Hy-Droxy-3-Oxo-4-Cholestenoic Acid and 24-Hydroxycholesterol Concentrations in Idiopathic Normal Pressure Hydrocephalus

Brain Sciences, 2022
Idiopathic normal pressure hydrocephalus (iNPH) is the most common form of hydrocephalus in the adult population, and is often treated with cerebrospinal fluid (CSF) drainage using a ventriculoperitoneal (VP) shunt.
Emanuele Porru, Erik Edström, Lisa Arvidsson, Adrian Elmi-Terander, Alexander Fletcher-Sandersjöö, Anita Lövgren Sandblom, Magnus Hansson, Frida Duell, Ingemar Björkhem   +8 more
doaj   +1 more source

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Journal of Lipid Research, 1998
We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol in the human body and that there is a net flux of this steroid from the brain into the circulation (Lütjohann, D. et al. 1996. Proc. Natl. Acad. Sci. USA. 93:
Ingemar Björkhem, Dieter Lütjohann, Ulf Diczfalusy, Lars Ståhle, Gunvor Ahlborg, John Wahren   +5 more
doaj   +1 more source

24S-hydroxycholesterol: cellular effects and variations in brain diseases [PDF]

, 2020
The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or 24-cholesterol hydroxylase ...
Alejandro O. Sodero, Sodero, Alejandro O., Sodero, Alejandro Omar   +2 more
core   +1 more source

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol

Journal of Lipid Research, 2001
Infants with the cholesterol synthesis defect Smith-Lemli-Opitz syndrome (SLO) have reduced activity of the enzyme 7-dehydrocholesterol-7-reductase and accumulate 7-dehydrocholesterol, with the highest concentration in the brain.
Ingemar Björkhem, Lena Starck, Ulla Andersson, Dieter Lütjohann, Sara von Bahr, Irina Pikuleva, Amir Babiker, Ulf Diczfalusy   +7 more
doaj   +1 more source

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols[S]

Journal of Lipid Research, 2014
Iso-octyl chain-hydroxylated oxysterols were determined in attomoles per 10,000 cells concentrations in 10,000–80,000 cultured pancreatic adenocarcinoma cells, using a sensitive, highly automated nano-LC-ESI-MS-based method.
Hanne Roberg-Larsen, Kaja Lund, Tore Vehus, Nina Solberg, Caroline Vesterdal, Dorna Misaghian, Petter Angell Olsen, Stefan Krauss, Steven Ray Wilson, Elsa Lundanes   +9 more
doaj   +1 more source

Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism

Cell Death Discovery, 2022
Perturbation of proteostasis triggers the adaptive responses that contribute to the homeostatic pro-survival response, whereas disruption of proteostasis can ultimately lead to cell death. Brain-specific oxysterol—i.e., 24(S)-hydroxycholesterol (24S-OHC)—
Yasuomi Urano, Shoya Osaki, Ren Chiba, Noriko Noguchi   +3 more
doaj   +1 more source

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study

Journal of Lipid Research, 2001
The major oxysterols in human circulation are 7α-, 27-, and (24S)-hydroxycholesterol. Two unique experiments were performed to elucidate their origin and kinetics. A volunteer was exposed to 18O2-enriched air. A rapid incorporation of 18O in both 7α- and
Steve Meaney, Moustapha Hassan, Augustinas Sakinis, Dieter Lütjohann, Klaus von Bergmann, Åke Wennmalm, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source

24-hydroxycholesterol moderates the effects of amyloid-β on expression of HMG-CoA reductase and ABCA1 proteins in mouse astrocytes

Advanced Biomedical Research, 2023
Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA
Zahra Nazeri, Ghorban Mohammadzadeh, Mojtaba Rashidi, Shirin Azizdoost, Maryam Cheraghzadeh, Alireza Kheirollah   +5 more
doaj   +1 more source