Results 41 to 50 of about 9,716 (212)

Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism

Cell Death Discovery, 2022
Perturbation of proteostasis triggers the adaptive responses that contribute to the homeostatic pro-survival response, whereas disruption of proteostasis can ultimately lead to cell death. Brain-specific oxysterol—i.e., 24(S)-hydroxycholesterol (24S-OHC)—
Yasuomi Urano, Shoya Osaki, Ren Chiba, Noriko Noguchi   +3 more
doaj   +1 more source

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS). We have measured the levels of over 20 non-esterified sterols in plasma and cerebrospinal fluid (CSF) from patients suffering from MS, inflammatory CNS ...
A Reboldi, A Saeed, A Solomon, A Szanto, AH Beecham, Andreas W. Sailer, B Goodwin, BA Janowski, C Hong, C Liu, CY Lee, D Meffre, DJ Parks, DR Bauman, DW Russell, F Chalmin, H Lassmann, I Björkhem, I Björkhem, I Björkhem, J Brown III, J Zhang, Jens Kuhle, JG Cyster, JG McDonald, JM Lehmann, Jonas Abdel-Khalik, Juan Zhang, K Park, L Mateos, LH Kasper, M Blanc, M Inoue, M Ogundare, MA Friese, Martin Beibel, N Zelcer, NJ Spann, P Soroosh, Peter J. Crick, PJ Crick, S Hannedouche, S Meaney, S Theofilopoulos, SV Ramagopalan, SY Liu, U Diczfalusy, V Leoni, William J. Griffiths, Y Wang, Yuqin Wang, Z Wang   +51 more
core   +1 more source

Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury [PDF]

Brain Injury, 2008
To determine if plasma levels of 24S-hydroxycholesterol, the primary catabolite of brain cholesterol, provide a measure of axonal damage in acute brain trauma.Determination of plasma 24S-hydroxycholesterol in a series of persons admitted to an intensive care unit for treatment of closed head injury.Levels of 24-S-hydroxycholesterol, 27 ...
Myron F, Weiner, Gloria L, Vega, Ramon, Diaz-Arrastia, Carol, Moore, Christopher, Madden, Anne, Hudak, Dieter, Lütjohann   +6 more
openaire   +2 more sources

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study

Journal of Lipid Research, 2001
The major oxysterols in human circulation are 7α-, 27-, and (24S)-hydroxycholesterol. Two unique experiments were performed to elucidate their origin and kinetics. A volunteer was exposed to 18O2-enriched air. A rapid incorporation of 18O in both 7α- and
Steve Meaney, Moustapha Hassan, Augustinas Sakinis, Dieter Lütjohann, Klaus von Bergmann, Åke Wennmalm, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source

Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators [PDF]

, 2004
Increasing biological and clinical findings argue for a link between brain cholesterol turnover and Alzheimer Disease (AD), high cerebral levels of the former increasing Abeta load.
AGOSTI C, AKKAWI N, ARCHETTI S, BORRONI, Barbara, BRAMBILLA C, CAIMI, Luigi, CALTAGIRONE C, DI LUCA M, PADOVANI, Alessandro   +8 more
core   +1 more source

Expression Cloning of an Oxysterol 7α-Hydroxylase Selective for 24-Hydroxycholesterol [PDF]

Journal of Biological Chemistry, 2000
The synthesis of 7alpha-hydroxylated bile acids from oxysterols requires an oxysterol 7alpha-hydroxylase encoded by the Cyp7b1 locus. As expected, mice deficient in this enzyme have elevated plasma and tissue levels of 25- and 27-hydroxycholesterol; however, levels of another major oxysterol, 24-hydroxycholesterol, are not increased in these mice ...
J, Li-Hawkins, E G, Lund, A D, Bronson, D W, Russell   +3 more
openaire   +2 more sources

24-hydroxycholesterol moderates the effects of amyloid-β on expression of HMG-CoA reductase and ABCA1 proteins in mouse astrocytes

Advanced Biomedical Research, 2023
Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA
Zahra Nazeri, Ghorban Mohammadzadeh, Mojtaba Rashidi, Shirin Azizdoost, Maryam Cheraghzadeh, Alireza Kheirollah   +5 more
doaj   +1 more source

Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterolss⃞

Journal of Lipid Research, 2007
In humans, the brain accounts for about 20% of the body's free cholesterol, most of which is synthesized de novo in brain. To maintain cholesterol balance throughout life, cholesterol becomes metabolized to 24S-hydroxycholesterol, principally in neurons.
Kersti Karu, Martin Hornshaw, Gary Woffendin, Karl Bodin, Mats Hamberg, Gunvor Alvelius, Jan Sjövall, John Turton, Yuqin Wang, William J. Griffiths   +9 more
doaj   +1 more source

Current trends in oxysterol research [PDF]

, 2016
In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the
Alvelius, Alwena H. Morgan, Andersson, Arnoldi, Bauman, Blanc, Clayton, Crick, de Medina, Diczfalusy, Dietschy, Eylan Yutuc, Fakheri, Gill, Goyal, Hannedouche, Heverin, Horton, Hu, Iuliano, Iuliano, Janowski, Jansen, Javitt, Jonas Abdel-Khalik, Klinke, Leonarduzzi, Liu, Lütjohann, Maarup, Meaney, Meljon, Murphy, Nelson, Ogundare, Porter, Radhakrishnan, Reboldi, Russell, Sacchetti, Santori, Schroepfer, Shackleton, Song, Soroosh, Theofilopoulos, Theofilopoulos, Thomas Hearn, Tint, Umetani, Wang, Wang, William J. Griffiths, Wu, Yuqin Wang   +54 more
core   +1 more source

Analysis of bioactive oxysterols in newborn mouse brain by LC/MS

Journal of Lipid Research, 2012
Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role.
Anna Meljon, Spyridon Theofilopoulos, Cedric H.L. Shackleton, Gordon L. Watson, Norman B. Javitt, Hans-Joachim Knölker, Ratni Saini, Ernest Arenas, Yuqin Wang, William J. Griffiths   +9 more
doaj   +1 more source