Results 61 to 70 of about 9,716 (212)

A clickable oxysterol photolabel retains NMDA receptor activity and accumulates in neurons [PDF]

, 2018
Oxysterol analogs that modulate NMDA receptor function are candidates for therapeutic development to treat neuropsychiatric disorders. However, the cellular actions of these compounds are still unclear.
Benz, Ann, Chen, Daniel M, Covey, Douglas F, Mennerick, Steven, Qian, Mingxing, Ziolkowski, Luke, Zorumski, Charles F   +6 more
core   +3 more sources

Modulation of Muller cell membrane organization by 24S‐hydroxycholesterol

Acta Ophthalmologica, 2017
PurposeMuller glial cells (MGC) are involved in the retinal homeostasis and they are sustaining cholesterol homeostasis. A lack or an excess of cholesterol in neurons can cause neuro‐degeneration. Cholesterol is eliminated from the retina mainly as 24S‐hydroxycholesterol (24S‐OHC).
P.H. Gabrielle, S. Gambert, E. Masson, E. Leger‐Charnay, A. Ferrerro, A. Vannier, C. Gendrault, M. Lachot, C. Creuzot‐Garcher, A. Bon, S. Gregoire, L. Leclere, L. Martine, G. Lucchi, C. Truntzer, L. Bretillon   +15 more
openaire   +1 more source

Lipids under stress - a lipidomic approach for the study of mood disorders [PDF]

, 2015
The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of ...
Antonny, Arevalo, Bazinet, Bessa, Björkhem, Bligh, Bozek, Brügger, Buchenauer, Catania, Cermenati, Cerqueira, Cerruti, Chan, Chang, Choi, Chuang, Dawson, De Kroon, Delisi, Di Paolo, Di Paolo, Dias, Dias-Ferreira, Dietschy, Dunkley, Fahy, Fahy, Feder, Giovacchini, Green, Green, Guan, Gulbins, Han, Hannun, Hartmann, Heverin, Holthuis, Holthuis, Huang, Karran, Kassas, Kay, Kielkowska, Kim, Kloda, Klose, Kodigepalli, Kornhuber, Lam, Lamaziere, Lee, Lev, Levant, Little, Liu, Lupien, Lütjohann, Maceyka, Malcher-Lopes, Mapstone, McMahon, McNamara, Mesmin, Miller, Morel, Mouritsen, Movahed, Müller, Nestler, Nestler, Nguyen, Nicolson, Oliveira, Oliveira, Oliveira, Ortolani, Pinto, Piomelli, Popoli, Prasad, Prasad, Puri, Radhakrishnan, Ricart-Jané, Roozendaal, Sanchez, Sanchez-Mejia, Schauder, Schultz, Shevchenko, Simons, Simons, Sousa, Sousa, Sousa, Sousa, Subramanian, Sundaram, Takamori, Thatcher, Tiemeier, Van Meer, Vetrivel, Wakelam, Walter, Wenk, Wenk, Williamson, Wymann, Yang, Zhang, Zhang, Zolov   +114 more
core   +1 more source

Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry

Journal of Lipid Research, 2004
24S-Hydroxycholesterol (24S-OH-Chol) and 27-hydroxycholesterol (27-OH-Chol) are oxidized derivatives of cholesterol and of potential diagnostic interest because their circulating levels may reflect the cholesterol metabolism of the brain and macrophages,
Ines Burkard, Katharina M. Rentsch, Arnold von Eckardstein   +2 more
doaj   +1 more source

Cholesterol 24S-Hydroxylase overexpression inhibits the liver X receptor (LXR) pathway by activating small guanosine triphosphate-binding proteins (sGTPases) in neuronal cells [PDF]

, 2014
The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in ...
Björkhem, Ingemar, Cedazo-Minguez, Angel, Gama, Maria João, Gomes, Anita Q., Moutinho, Miguel, Nunes, Maria João, Rodrigues, C. M., Rodrigues, Elsa   +7 more
core   +1 more source

Multiplexed Tandem Mass Spectrometry Imaging Enables Large‐Scale Isomer Mapping and Annotation in Tissues

Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.
Parallel mass spectrometry imaging acquires high mass resolution and tandem mass spectrometry images from 108 isolation windows in a single run. Spatial similarity networking clusters product ions by spatial distribution, enabling annotation of isomers and isobars as demonstrated for phospholipids and oxidized cholesterol in mouse and human brain ...
Varun V. Sharma, Gabor Toth, Robert Martinis, Cathrin E. Hansen, Gijs Kooij, Ingela Lanekoff   +5 more
wiley   +2 more sources

Effects of Hypercholesterolaemia in the Retina [PDF]

, 2012
© 2012 Triviño et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in
Gallego Collado, Beatriz Isabel, Hoz Montañana, María Rosa de, Ramirez Sebastian, Jose Manuel, Ramírez Sebastián, Ana Isabel, Rojas López, María Blanca, Salazar Corral, Juan José, Triviño Casado, Alberto   +6 more
core   +2 more sources

Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death[S]

Journal of Lipid Research, 2016
The 24(S)-hydroxycholesterol (24S-OHC), which plays an important role in maintaining brain cholesterol homeostasis, has been shown to possess neurotoxicity. We have previously reported that 24S-OHC esterification by ACAT1 and the resulting lipid droplet (
Wakako Takabe, Yasuomi Urano, Diep-Khanh Ho Vo, Kimiyuki Shibuya, Masaki Tanno, Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi   +7 more
doaj   +1 more source

Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. [PDF]

, 2020
IntroductionDisruption of metabolic function is a recognized feature of late onset Alzheimer's disease (LOAD). We sought to determine whether similar metabolic pathways are implicated in adults with Down syndrome (DS) who have increased risk for ...
Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators, Cheema, Amrita K, Christian, Bradley T, Gross, Thomas J, Handen, Benjamin L, Head, Elizabeth, Klunk, William E, Lott, Ira T, Macciardi, Fabio, Mapstone, Mark, Petersen, Melissa, Schupf, Nicole, Silverman, Wayne   +12 more
core  

Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats [PDF]

, 2010
Background Apolipoprotein E (apoE) is a major cholesterol transport protein found in association with brain amyloid from Alzheimer's disease (AD) patients and the ε4 allele of apoE is a genetic risk factor for AD.
Sokreine Suon, Jie Zhao, Stephanie A Villarreal, Nikesh Anumula, Mali Liu, Linda M Carangia, John J Renger, Celina V Zerbinatti   +7 more
core   +1 more source