Results 81 to 90 of about 9,716 (212)

Plasma oxysterols: Altered level of plasma 24-hydroxycholesterol in patients with bipolar disorder

The Journal of Steroid Biochemistry and Molecular Biology, 2021
Cholesterol and its oxygenated metabolites, including oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorders. Altered oxysterol levels have been described in patients with numerous neuropsychiatric disorders.
Guidara, Wassim, Messedi, Meriam, Maalej, Manel, Naifar, Manel, Khrouf, Walid, Grayaa, Sahar, Maalej, Mohamed, Bonnefont-Rousselot, Dominique, Lamari, Foudil, Ayadi, Fatma   +9 more
openaire   +3 more sources

Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models

Neuroscience Research
We investigated whether soticlestat (TAK-935), a newly discovered cholesterol 24-hydroxylase (CH24H) inhibitor now in phase 3 clinical trials for Dravet and Lennox-Gastaut syndromes, has effects on neurodegeneration in both chronic and acute animal ...
Shigeo Hasegawa, Sayuri Watanabe, Shinji Fujimoto, Shinichi Kondo, Toshiya Nishi   +4 more
doaj   +1 more source

Cholesterol homeostasis: a key to prevent or slow down neurodegeneration [PDF]

, 2013
Neurodegeneration, a common feature for many brain disorders, has severe consequences on the mental and physical health of an individual. Typically human neurodegenerative diseases are devastating illnesses that predominantly affect elderly people ...
Anchisi L., Dessi S., Mandas A, Pani A.
core   +1 more source

Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0).

Biochimie, 2018
Little is known about K+ regulation playing major roles in the propagation of nerve impulses, as well as in apoptosis and inflammasome activation involved in neurodegeneration.
M. Bezine, Sonia Maatoug, R. Ben Khalifa, Meryam Debbabi, A. Zarrouk, Yuqin Wang, W. Griffiths, T. Nury, M. Samadi, A. Véjux, J. de Seze, T. Moreau, R. Kharrat, M. el Ayeb, G. Lizard   +14 more
semanticscholar   +1 more source

Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome

Epilepsia, EarlyView.
Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan, Kette Valente, Vicente Villanueva, Adam Strzelczyk, Rima Nabbout, Eiji Nakagawa, Yuehua Zhang, Marta Zolnowska, Yasir Khan, Cheng Dong, Samuel Hsiao, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Venkatesha Murthy   +14 more
wiley   +1 more source

Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals

Neurobiology of Aging, 2009
The present study assessed the association between serum 24S-hydroxycholesterol (24S-OH-Chol) and 27-hydroxycholesterol (27-OH-Chol) and hippocampal volumes in 69 middle-aged cognitively normal individuals. Results showed that subjects with high levels of oxysterols had significantly larger hippocampal volumes than subjects with low levels of ...
Koschack, Janka, Luetjohann, Dieter, Schmidt-Samoa, Carsten, Irle, Eva   +3 more
openaire   +3 more sources

Farnesoid X receptor and liver X receptor ligands initiate formation of coated platelets [PDF]

, 2017
The liver X receptors (LXRs) and farnesoid X receptor (FXR) have been identified in human platelets. Ligands of these receptors have been shown to have nongenomic inhibitory effects on platelet activation by platelet agonists.
Alberio L, Alberio LJ, Alexander P. Bye, Amanda J. Unsworth, Chris I. Jones, Dionne S. Tannetta, Harriet E. Allan, Jobe S, Jonathan M. Gibbins, Marilena Crescente, Michael J.R. Desborough, Neline Kriek, Parveen Yaqoob, Shimada H, Tanya Sage, Timothy D. Warner   +15 more
core   +1 more source

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice [PDF]

, 2020
Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that converts cholesterol into 24S-hydroxycholesterol, the primary mechanism of cholesterol catabolism in the brain.
Ando, Haruhi Kamisaki, During, Matthew J., Farnaby, William, Fujimoto, Shinji, Hasegawa, Shigeo, Ishi, Tsuyoshi, Koike, Tatsuki, Kondo, Shigeru, Kondo, Shinichi, Kuroita, Takanobu, Miyamoto, Maki, Nishi, Toshiya, Ohori, Momoko, Sunahara, Eiji, Watanabe, Etsurou, Watanabe, Sayuri, Yano, Jason, Yoshikawa, Masato   +17 more
core   +2 more sources

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons [PDF]

Biochemical Journal, 1997
The metabolism of 27-, 25- and 24-hydroxycholesterol in cultures of rat astrocytes, Schwann cells and neurons was studied. 27- and 25-Hydroxycholesterol, but not 24-hydroxycholesterol, underwent 7α-hydroxylation with subsequent oxidation to 7α-hydroxy-3-oxo-Δ4 steroids in all three cell types.
J, Zhang, Y, Akwa, M, el-Etr, E E, Baulieu, J, Sjövall   +4 more
openaire   +2 more sources