Results 81 to 90 of about 6,427 (151)

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin, Yingying Ren, Jing Li, Panxing Ren, Xinran Wang, Yixin Ding, Linsu Liu, Cong Liu, Zhou Li, Yan Liu, Dan Luo   +10 more
wiley   +1 more source

Plasma 24S-hydroxycholesterol : a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease

, 2000
The conversion of brain cholesterol into 24S-hydroxycholesterol and its subsequent release into the periphery is probably an important step for the maintenance of brain cholesterol homeostasis.
Bagli, M., Locatelli, S., Heun, R., Maier, W., Lütjohann, D., Jessen, F., Rao, M. L., von Bergmann, K., Papassotiropoulos, A., Björkhem, I.   +9 more
core  

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1

Journal of Lipid Research, 2013
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem   +9 more
doaj   +1 more source

24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells.

, 2019
The cholesterol metabolite 24(S)-hydroxycholesterol (24S-OHC) allows cholesterol excretion from the brain and was suggested to be critically involved in physiological as well as neurodegenerative processes.
Iannotta, Lucia, FASCIOLO, GIANLUCA, Iannotta L, Venditti, Paola, Cigliano L, Spagnuolo MS, Barone D, Barone, Daniela, Venditti P, Napolitano, Gaetana, Cigliano, Luisa, Napolitano G, Spagnuolo, Maria Stefania   +12 more
core   +1 more source

JCB911910 Supplemental Material - Supplemental material for Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice

, 2020
Supplemental material, JCB911910 Supplemental Material for Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice by Fuxin Lu, Shujuan Fan, Andrea R Romo, Duan Xu, Donna M Ferriero
Fuxin Lu (8579544), Andrea R Romo (8579547), Duan Xu (333745), Donna M Ferriero (8579550), Shujuan Fan (8380047), Xiangning Jiang (1965043)   +5 more
core   +1 more source

24S,25-Epoxycholesterol in mouse and rat brain [PDF]

, 2014
24S,25-Epoxycholesterol is formed in a shunt of the mevalonate pathway that produces cholesterol. It is one of the most potent known activators of the liver X receptors and can inhibit sterol regulatory element-binding protein processing.
Seckl, Jonathan R, Griffiths, William J, Seckl, Jonathan R., Yuqin Wang, Meljon, Anna, William Griffiths, Turton, John, Karu, Kersti, Wang, Yuqin, Wang, Yuchen, Griffiths, William J., Yau, Joyce L., Yau, Joyce L; id_orcid   +12 more
core   +1 more source

Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0) [PDF]

, 2018
International audienceLittle is known about K+ regulation playing major roles in the propagation of nerve impulses, as well as in apoptosis and inflammasome activation involved in neurodegeneration.
Rym Ben Khalifa, Griffiths, William J, Sèze, Jérôme,, Gérard Lizard, Samadi, Mohammad, Kharrat, Riadh, Lizard, Gérard, Ben Khalifa, Rym, Riadh Kharrat, Mohamed El Ayeb, Mohammad Samadi, William J. Griffiths, Sèze, Jérôme, De, Moreau, Thibault, Thomas Nury, Vejux, Anne, El Ayeb, Mohamed, Debbabi, Meryam, Sonia Maatoug, Anne Vejux, Maatoug, Sonia, Yuqin Wang, Jérôme de Sèze, William Griffiths, Bezine, Maryem, Maryem Bezine, Wang, Yuqin, Nury, Thomas, Thibault Moreau, Zarrouk, Amira, Amira Zarrouk, Meryam Debbabi   +31 more
core   +1 more source

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

Journal of Lipid Research, 2010
Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on its activity have been described.
Marjan Shafaati, Natalia Mast, Olof Beck, Rima Nayef, Gun Young Heo, Linda Björkhem-Bergman, Dieter Lütjohann, Ingemar Björkhem, Irina A. Pikuleva   +8 more
doaj   +1 more source

Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes. [PDF]

Front Aging Neurosci, 2021
Shi J, Jia J, Tian S, Zhang H, An K, Zhu W, Cao W, Yuan Y, Wang S.   +8 more
europepmc   +1 more source

Influence of the peroxisome proliferator-activated receptor y gene polymorphism on 24S-cholesterol levels in Alzheimer patients

, 2005
The peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear hormone receptor, that is involved in lipid and glucose metabolism, which both seem to influence the risk of Alzheimer's disease (AD).
Kolsch, H, Sauder, S, Lutjohann, D, Maier, W, Heun, Reinhard, Schulz, A, von Bergmann, K   +6 more
core   +1 more source