Results 81 to 90 of about 1,152 (159)

CYP46A1‐Targeted Treatment Alleviates Long‐Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li, You Shi, Qing Luo, Peiwen Guo, Taotao Jin, Xufang Ru, Zhouyang Jiang, Yin Niu, Wenyan Li, Yujie Chen, Zhi Chen   +10 more
wiley   +1 more source

Diagnostic Power of 24S-Hydroxycholesterol in Cerebrospinal Fluid: Candidate Marker of Brain Health

Journal of Alzheimer’s Disease, 2013
We evaluated the diagnostic potential of 24S-hydroxycholesterol (24OHC) in cerebrospinal fluid. At a memory clinic, we investigated subjects with subjective cognitive impairment (SCI, n = 33), mild cognitive impairment (MCI) patients (n = 27), MCI patients with later progression into Alzheimer dementia at follow up (n = 10), and ...
Leoni, V, Solomon, A, Lövgren-Sandblom, A, Minthon, L, Blennow, K, Hansson, O, Wahlund, LO, Kivipelto, M, Björkhem, I   +8 more
openaire   +3 more sources

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

On the substrate specificity of human CYP27A1

Journal of Lipid Research, 2003
The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin, Sara von Bahr, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1

Journal of Lipid Research, 2013
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem   +9 more
doaj   +1 more source

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

Journal of Lipid Research, 2010
Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on its activity have been described.
Marjan Shafaati, Natalia Mast, Olof Beck, Rima Nayef, Gun Young Heo, Linda Björkhem-Bergman, Dieter Lütjohann, Ingemar Björkhem, Irina A. Pikuleva   +8 more
doaj   +1 more source

Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes. [PDF]

Front Aging Neurosci, 2021
Shi J, Jia J, Tian S, Zhang H, An K, Zhu W, Cao W, Yuan Y, Wang S.   +8 more
europepmc   +1 more source

Relevance of 24S-hydroxycholesterol as a biomarker of optic neuropathies

, 2010
Purpose: 24S-Hydroxycholesterol is formed by enzymatic oxidation of cholesterol via cholesterol-24S-hydroxylase (CYP46A1) activity in neurons, including retinal ganglion cells and neurons from the inner retina. We investigated whether neurodegeneration could be associated with the release of 24S-hydroxycholesterol in acute neuropathies, and therefore ...
Brétillon, Lionel, Martine, Lucy, Pasquis, Bruno, Fourgeux, Cynthia, Schnebelen, Coralie, Acar, Niyazi, Bjorkhem, Ingemar, Bron, Alain, Creuzot Garcher, Catherine   +8 more
openaire   +2 more sources