Results 91 to 100 of about 6,427 (151)

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

, 2007
International audienceIncreasing biological findings argue for the importance of cholesterol-24S-hydroxylase (CYP46A1) in cholesterol homeostasis in cerebral structures.
Brétillon, Lionel, Creuzot-Garcher, C, Martine, Lucy, Creuzot-Garcher, Catherine, Joffre, Corinne, Diczfalusy, Ulf, Creuzot Garcher, Catherine, Martine, L, Diczfalusy, U,, Bron, Alain, M., Bjoerkhem, I, Bron, A, Maire, Marie-Annick, Bjorkhem, Ingemar, Maire, MA, Acar, Niyazi, Acar, N, Bretillon, L, Bron, Alain,, Lucy, Martine, Joffre, C   +20 more
core   +1 more source

Estudo bioquímico e comportamental em camundongos submetidos à infusão intracerebroventricular dos peptídeos beta-amilóide AB1-40 E AB25-35 e o papel neuroprotetor da atorvastatina [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.The accumulation and aggregation of beta-amyloid peptide (Aâ) in brain of patients with Alzheimer's disease results
Piermartiri, Tetsade Camboim Bizerra
core  

Cholesterol 24S-hydroxylase: Involvement in Brain Injury and Disease.

, 2008
PhDHere we investigated whether traumatic brain injury (TBI) altered the regulation of cholesterol 24S-hydroxylase (Cyp46), an enzyme that converts cholesterol to the more hydrophilic 24S-hydroxycholesterol.
Cartagena, Casandra Marie
core  

In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina

, 2014
International audienceCholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol in neurons and participates in cholesterol homeostasis in the central nervous system, including the retina. We aimed to evaluate the consequences
Brétillon, Lionel, Martine, Lucy, Creuzot-Garcher, Catherine, Acar, Niyazi, Bron, Alain, M., Fourgeux, Cynthia   +5 more
core   +1 more source

Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia. [PDF]

NPJ Schizophr, 2020
Chiappelli J, Quinton MS, Volfson D, Cwik M, Marshall W, Bruce H, Goldwaser E, Kvarta M, Summerfelt A, Kochunov P, O'Donnell P, Hong LE.   +11 more
europepmc   +1 more source

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7 alpha-hydroxylase (CYP7A)

, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Toll, Anders,, Bjorkhem, Ingemar, Wikvall, Kjell,, Norlin, Maria,   +3 more
core  

Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7 beta-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of alpha-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)

, 2015
International audienceIn demyelinating or non-demyelinating neurodegenerative diseases, increased levels of 7-ketocholesterol (7KC), 7 beta-hydroxycholesterol (7 beta-OHC) and 24(S)-hydroxycholesterol (24S-OHC) can be observed in brain lesions.
Limagne, Emeric, Moreau, Thibault, Vejux, Anne, Prost, Michel, Delmas, Dominique, Samadi, Mohammad, Lizard, Gérard, Riedinger, Jean-Marc, Mackrill, John J., Hammami, Mohamed, Doria, Margaux, Nury, Thomas, Zarrouk, Amira, O'Brien, Nora M., Delage-Mourroux, Régis, Durand, Philippe   +15 more
core   +1 more source

Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma

Frontiers in Ophthalmology
Cholesterol is an essential component of cellular membranes, crucial for maintaining their structural and functional integrity. It is especially important for nervous tissues, including the retina, which rely on high amounts of plasma membranes for the ...
Elodie A.Y. Masson, Jeanne Serrano, Jeanne Serrano, Elise Leger-Charnay, Niyazi Acar   +4 more
doaj   +1 more source

In vivo consequences of cholesterol-24s-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina

, 2011
Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol in neurons and participates in cholesterol homeostasis in the central nervous system, including the retina. We aimed to evaluate the consequences of CYP46A1 inhibition
Pasquis, Bruno, Brétillon, Lionel, Martine, Lucy, Creuzot-Garcher, Catherine, Bron, Alain, Acar, Niyazi, Fourgeux, Cynthia   +6 more
core   +1 more source

Effects of Cholesterol and Its 24S-OH and 25-OH Oxysterols on Choline Acetyltransferase-Positive Neurons in Brain Slices

, 2010
In Alzheimer’s disease (AD) neurons expressing the enzyme choline acetyltransferase (ChAT) degenerate and a loss of cholinergic activity directly correlates with cognitive decline. Recent studies have suggested that cholesterol plays a role in AD.
Celine Ullrich, Christian Humpel, Michael Pirchl   +2 more
core   +1 more source