Results 111 to 120 of about 9,716 (212)

Statin Therapy Protects White Matter in Cerebral Small Vessel Disease Independent of Lipid‐Lowering: Biomarker and Neuroimaging Evidence

Brain and Behavior, Volume 16, Issue 5, May 2026.
This study, through an analysis of neuroimaging markers, biomarkers of white matter damage, and the volume of the hippocampal fimbria (a white matter structure) in patients with cerebral small vessel disease (CSVD), revealed that the protective effect of statin therapy against white matter damage in CSVD patients is independent of its lipid‐lowering ...
Rui Wang, Juluo Chen, Peiqi Ma, Lu Liu, Youmeng Wang, Qiqiang Tang   +5 more
wiley   +1 more source

Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study

BMC Neurology, 2011
Background In central nervous system cholesterol cannot be degraded but is secreted into circulation predominantly in the form of its polar metabolite 24(S)-hydroxycholesterol (24S-OH-Chol).
Bonetti Francesco, Zurlo Amedeo, Nora Edoardo, Passaro Angelina, Bosi Cristina, Donnorso Michela, Zuliani Giovanni, Mozzi Alessia F, Cortese Claudio   +8 more
doaj   +1 more source

Cholesterolomics: An update [PDF]

, 2017
Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample.
Alvelius, Alwena H. Morgan, Andersson, Axelson, Bauman, Bazan, Bjorkhem, Bjorkhem, Bjorkhem, Blanc, Byrne, Cobice, Crick, Crick, Davies, de Medina, Diczfalusy, Dzeletovic, Eylan Yutuc, Fakheri, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Gustafsson, Hannedouche, Hu, Ian Gilmore, Ikegami, Jiang, Jiang, Jonas Abdel-Khalik, Klinke, Korade, Kotti, Lehmann, Lin, Liu, Liu, Liu, Maioli, Matysik, Mazzacuva, McDonald, McDonald, McDonald, Myers, Nachtergaele, Nedelcu, Nelson, Novakova, Park, Pataj, Porter, Porter, Radhakrishnan, Reboldi, Roberg-Larsen, Roberg-Larsen, Robertson, Russell, Sacchetti, Saeed, Saeed, Santori, Schroepfer, Setchell, Sever, Shinkyo, Sidhu, Silvente-Poirot, Simigdala, Soncini, Soroosh, Stiles, Theofilopoulos, Theofilopoulos, Thomas Hearn, Wassif, Watabe, William J. Griffiths, Wu, Xu, Yuqin Wang, Zhang   +86 more
core   +1 more source

Gut Microbiota and Extraintestinal Cancers: Mechanistic Insights and Microbiome‐Targeted Interventions

JGH Open, Volume 10, Issue 5, May 2026.
ABSTRACT The gut microbiota is a dynamic community of bacteria, viruses, fungi, and archaea that plays a pivotal role in regulating host immunity, metabolism, and systemic homeostasis. Dysbiosis, characterized by an imbalance in the microbial composition, is being increasingly recognized as a contributor not only to gastrointestinal cancers but also to
Rishi Chowdhary, Manjeet Kumar Goyal, Kirti Arora, Tanisha Sehgal, Prachi Dawer, F. N. U. Anirudh, Jeffrey Berinstein, Shrinivas Bishu, Laurie Matt‐Amaral   +8 more
wiley   +1 more source

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain

Journal of Lipid Research, 2005
Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto the brain using plasma samples collected from the internal jugular ...
Maura Heverin, Steve Meaney, Dieter Lütjohann, Ulf Diczfalusy, John Wahren, Ingemar Björkhem   +5 more
doaj   +1 more source

A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism

Redox Biology, 2020
Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They are oxidation products of cholesterol and may be differentially metabolised in subcellular compartments and in biological fluids.
Khushboo Borah, Olivia J. Rickman, Nikol Voutsina, Isaac Ampong, Dan Gao, Emma L. Baple, Irundika HK. Dias, Andrew H. Crosby, Helen R. Griffiths   +8 more
doaj   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, Volume 183, Issue 10, Page 2236-2255, May 2026.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Reduction in Levels of 24S-Hydroxycholesterol by Statin Treatment in Patients With Alzheimer Disease [PDF]

Archives of Neurology, 2003
The statin treatment of dyslipidemia is associated with a reduced risk of development of Alzheimer disease (AD). The effect may be mediated by a reduction in cholesterol biosynthesis in the brain, by lowering levels of apolipoprotein E (apo E)-containing lipoproteins, or by pleitropic effects such as reduction in beta-amyloid production.
Gloria Lena, Vega, Myron F, Weiner, Anne M, Lipton, Klaus, Von Bergmann, Dieter, Lutjohann, Carol, Moore, Doris, Svetlik   +6 more
openaire   +2 more sources

Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis

Journal of Lipid Research, 2005
In a recent publication [Diestel, A., O. Aktas, D. Hackel, I. Häke, S. Meier, C. S. Raine, R. Nitsch, F. Zipp, and O. Ullrich. 2003. Activation of microglial poly (ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a ...
Valerio Leoni, Dieter Lütjohann, Thomas Masterman   +2 more
doaj   +1 more source

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, Volume 299, Issue 5, Page 628-638, May 2026.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source