Results 121 to 130 of about 1,152 (159)

(24S)-Hydroxycholesterol efflux from neuronal cells by ABC proteins

, 2014
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Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons

Feng Y, Mazumder B, Konno T, Hui E, Brockhoff M, Davi V, Lu M, Ward E, Stephens A, Dai W, Fernandez-Villegas A, Fusco G, Ali Asgari M, Avezov E, De Simone A, Wang Y, Griffiths WJ, Kaminski C, Kaminski Schierle G.   +18 more
europepmc   +1 more source

(24S)-Hydroxycholesterol efflux from neuronal cells by ABC proteins

(24S)-Hydroxycholesterol efflux from neuronal cells by ABC proteins
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Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer’s disease

Expert Review of Neurotherapeutics, 2006
Cholesterol and the cholesterol oxide 24S-hydroxycholesterol (24S-HC) are highly enriched in the human CNS. Clinical, genetic, neurochemical and epidemiological evidence continue to support dysfunctional cholesterol metabolism as an important contributing factor driving the development and/or progression of Alzheimer's disease (AD) neuropathology ...
Walter J Lukiw
exaly   +3 more sources

24S-Hydroxycholesterol: a Marker of Brain Cholesterol Metabolism

Pharmacopsychiatry, 2003
The enzymatic conversion of CNS cholesterol to 24S-hydroxycholesterol, which readily crosses the blood-brain barrier, is the major pathway for brain cholesterol elimination and brain cholesterol homeostasis maintenance. The enzyme mediating this conversion has been characterized at the molecular level (CYP46) and is mainly located in neurons.
D, Lütjohann, K, von Bergmann
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Degradation of 24S-hydroxycholesterol in men is not regulated by CYP7A1

Int. Journal of Clinical Pharmacology and Therapeutics, 2007
The conversion of cholesterol into bile acids occurs via a long cascade of enzymatically regulated oxidative processes. Our aim was to examine if an up-regulation of hepatic cholesterol 7alpha-hydroxylase (CYP7A1) in humans by cholestyramine, a bile acid-binding resin, has an effect on the degradation of brain-specific 24S-hydroxycholesterol.Six ...
C, Knabe, T, Sudhop, K, von Bergmann, D, Lütjohann   +3 more
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Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

Neuroscience Letters, 2000
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance.
Brétillon, Lionel, Siden, A., Wahlund, L.O., Lütjohann, D., Minthon, L., Crisby, M., Hillert, J., Groth, C.G., Diczfalusy, U., Bjorkhem, Ingemar   +9 more
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Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): Argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity

Revue Neurologique, 2015
Cholesterol oxide derivatives (oxysterols) are viewed as potential biomarkers of neurodegenerative diseases. 24S-hydroxycholesterol, an oxysterol produced only in brain neurons, is often found for unknown reasons in increased levels in the plasma in patients with neurodegenerative diseases. On human neuronal SK-N-BE cells treated with hexacosanoic acid
M Hammami, T Moreau, Gérard Lizard
exaly   +3 more sources

Plasma 24S-hydroxycholesterol

NeuroReport, 2000
The conversion of brain cholesterol into 24S-hydroxycholesterol and its subsequent release into the periphery is probably an important step for the maintenance of brain cholesterol homeostasis. Recent findings suggest that plasma 24S-hydroxycholesterol may be elevated in Alzheimer's disease (AD) and vascular dementia at least at some stage of the ...
Papassotiropoulos, A., Lütjohann, D., Bagli, M., Locatelli, S., Jessen, F., Rao, M. L., Maier, W., Björkhem, I., von Bergmann, K., Heun, R.   +9 more
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24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

Journal of Psychiatric Research, 2002
The brain is the most cholesterol-rich organ in the human body. Accumulation of excess cholesterol in hippocampal neurons promotes the cleavage of the amyloid precursor protein (APP) into amyloidogenic components with the consequence of the acceleration of neuronal degeneration.
Papassotiropoulos, A., Lütjohann, D., Bagli, M., Locatelli, S., Jessen, F., Buschfort, R., Ptok, U., Björkhem, I., von Bergmann, K., Heun, R.   +9 more
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