Results 121 to 130 of about 9,716 (212)
Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease [PDF]
, 2011 In spite of the fact that cholesterol does not pass the blood-brain barrier, hypercholesterolemia has been linked to increase Alzheimer's disease (AD) risk.
Björkhem, I. (Ingemar) +6 more
core +1 more source
The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in A beta generation [PDF]
, 2016 The receptor interacting protein-140 (RIP140) is a cofactor for several nuclear receptors and has been involved in the regulation of metabolic and inflammatory genes.
Blondrath, K +6 more
core
Cholesterol impairment contributes to neuroserpin aggregation [PDF]
, 2017 Intraneural accumulation of misfolded proteins is a common feature of several neurodegenerative pathologies including Alzheimer's and Parkinson's diseases, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). FENIB is a rare disease due
Costantini, Giulio +5 more
core +2 more sources
Screening and Identification of APOC1 as a Novel Potential Biomarker for Differentiate of Mycoplasma pneumoniae in Children [PDF]
, 2016 Background: Although mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia in children, the currently used diagnostic methods are not optimal.
Adong Shen +9 more
core +2 more sources
Advanced Science, Volume 13, Issue 23, 23 April 2026.The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang +13 more
wiley +1 more source
On the substrate specificity of human CYP27A1
Journal of Lipid Research, 2003 The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin +3 more
doaj +1 more source
Cancer Nexus, Volume 2, Issue 2, April 2026.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source
Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice [PDF]
, 2014 Huntington’s disease (HD) disturbs glucose metabolism in the brain by poorly understood mechanisms. HD neurons have defective glucose uptake, which is attenuated upon enhancing rab11 activity.
DiFiglia, Marian +6 more
core +1 more source
Expression of junctional proteins in choroid plexus epithelial cell lines: a comparative study [PDF]
, 2007 Background There is an increasing interest in using choroid plexus (CP) epithelial cell lines to study the properties of the blood-cerebrospinal fluid barrier (BCSFB). Currently, there are three major CP-derived cell lines available.
Joanna Szmydynger-Chodobska +4 more
core +1 more source
Journal of Lipid Research, 2010 Cholesterol 24S-hydroxylase (CYP46A1) is of key importance for cholesterol homeostasis in the brain. This enzyme seems to be resistant toward most regulatory factors and at present no drug effects on its activity have been described.
Marjan Shafaati +8 more
doaj +1 more source