Results 131 to 140 of about 1,152 (159)

24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases

Biochimie, 2013
Brain cholesterol is mainly involved in the cell membrane structure, in signal transduction, neurotransmitter release, synaptogenesis and membrane trafficking. Impairment of brain cholesterol metabolism was described in neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer and Huntington Diseases.
Leoni, V, Caccia, C
openaire   +3 more sources

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease [PDF]

Brain, 2008
Huntington's disease (HD) is a hereditary neurodegenerative disorder for which biological indicators of disease progression, or disease stage, would be especially important for therapeutic trials. 24S-hydroxycholesterol (24OHC) is a brain-generated cholesterol metabolite which has been associated with neurodegeneration, and alterations of cholesterol ...
Valerio Leoni, Caterina Mariotti, Marta Valenza   +2 more
exaly   +5 more sources

24S‐hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis

Journal of Neuroscience Research, 2007
AbstractLevels of the brain‐specific cholesterol metabolite 24S‐hydroxycholesterol are proposed as possible biomarkers for multiple sclerosis (MS). It is not yet clear for which aspect of the MS disease manifestations 24S‐hydroxycholesterol is a reflection.
Teunissen, C E, Floris, S, Sonke, M, Dijkstra, C D, De Vries, H E, Lütjohann, D   +5 more
openaire   +3 more sources

The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells

Brain Research, 1999
Neurodegenerative disorders are characterized by a massive loss of nerve cells. The neuronal cell death is accompanied by an increased cholesterol release and conversion of cholesterol into the polar metabolite, 24-hydroxycholesterol (24-OH-Chol), appears to be an important mechanism in the central nervous system for eliminating cholesterol from the ...
H, Kölsch, D, Lütjohann, A, Tulke, I, Björkhem, M L, Rao   +4 more
openaire   +2 more sources

The role of 24S-hydroxycholesterol in Alzheimer's disease.

The journal of nutrition, health & aging, 2003
Studies on Alzheimer's disease (AD) revealed that cholesterol metabolism might be involved in the pathogenesis of this neurodegenerative disorder. The apolipoprotein E4 genotype is a known risk factor in AD. Elevated serum cholesterol concentrations are detected in patients with AD and two recent epidemiological studies have indicated that treatment ...
H, Kölsch, D, Lütjohann, K, von Bergmann, R, Heun   +3 more
openaire   +1 more source

Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S‐hydroxycholesterol

Acta Paediatrica, 2001
Oxysterols, particularly those hydroxylated in the steroid side‐chain, are formed from cholesterol by specific cytochrome P450 enzymes and may facilitate elimination of cholesterol from extrahepatic sources. In humans, the greatest portion of circulating 24S‐hydroxycholesterol (24S‐OH‐Chol) is derived from the brain and the absolute concentration ...
D, Lütjohann, I, Björkhem, S, Locatelli, C, Dame, J, Schmolling, K, von Bergmann, H, Fahnenstich   +6 more
openaire   +2 more sources

Lecithin cholesterol acyltransferase esterifies 24s-hydroxycholesterol in cerebrospinal fluid

2010
Alteration of cholesterol (Ch) homeostasis is involved in the pathogenesis of neurodegeneration. Astrocyte-derived lecithin cholesterol acyltransferase (LCAT) was recently shown capable of esterifying Ch on ApoE-lipoproteins.In order to prevent Ch excess in neurons, it can be converted in 24Shydroxycholesterol (24-OH Ch).
CIGLIANO, LUISA, Spagnuolo M. S., Maresca B., Pugliese C. R., La Marca V., ABRESCIA, PAOLO   +5 more
openaire   +3 more sources

Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol

Chemistry and Physics of Lipids, 2017
Glaucoma is a progressive and irreversible blinding neuropathy that is characterized by the loss of retinal ganglion cells (RGCs). Muller Glial Cell (MGC) activation is induced in retinal gliosis. MGCs are the most numerous glial cells in the retina and one of their roles is to sustain cholesterol homeostasis. 24S-hydroxycholesterol (24S-OHC) is one of
Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, A Bron   +2 more
exaly   +4 more sources

The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease

2023
Cholesterol regulates fluidity and structure of cellular membranes. The brain is involved in signal transduction, synaptogenesis, and membrane trafficking. An impairment of its metabolism was observed in different neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer, and Huntington diseases.
Tripodi D., Vitarelli F., Spiti S., Leoni V.   +3 more
openaire   +2 more sources

24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder, and Bipolar Disorder

2023
Neuropsychiatric diseases (NPDs) are severe, debilitating psychiatric conditions that affect the nervous system. These are among the most challenging disorders in medicine. Some examples include Alzheimer's, anxiety disorders, autism spectrum disorder, bipolar disorder, and schizophrenia.
Meriam, Messedi, Fatma, Makni-Ayadi
openaire   +2 more sources