Results 131 to 140 of about 6,427 (151)

Mechanism of conductance control and neurosteroid binding in NMDA receptors. [PDF]

Nature
Kang H, Steigerwald R, Ullman EZ, Epstein M, Paladugu S, Liotta DC, Traynelis SF, Furukawa H.   +7 more
europepmc   +1 more source

Sterol imbalances and cholesterol-24-hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis. [PDF]

Brain Pathol
Griffiths L, Hawkins K, Yutuc E, Angelini R, Fosuah R, Pacciarini M, Dickson A, Robertson N, Childs L, Loveless S, Tallantyre E, Griffiths WJ, Wang Y, Howell OW.   +13 more
europepmc   +1 more source

Current approaches to predicting intraventricular hemorrhage in preterm neonates using blood biomarkers. [PDF]

Front Pediatr
Kasíková M, Brož P, Dort J, Topolčan O.   +3 more
europepmc   +1 more source

Deletion of CH25H and LIPA Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant^‡

Yutuc E, Ghosh A, Abdel-Khalik J, Goenka A, Asgari MA, Lopez-Castejon G, Beaman GM, Wynn RF, Newman WG, Jones SA, Griffiths WJ, Wang Y.   +11 more
europepmc   +1 more source

Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons

Feng Y, Mazumder B, Konno T, Hui E, Brockhoff M, Davi V, Lu M, Ward E, Stephens A, Dai W, Fernandez-Villegas A, Fusco G, Ali Asgari M, Avezov E, De Simone A, Wang Y, Griffiths WJ, Kaminski C, Kaminski Schierle G.   +18 more
europepmc   +1 more source

Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers

Atherosclerosis, 2007
24S- and 27-hydroxycholesterol are obligatory intermediates of cholesterol catabolism and play an important role in the maintenance of whole-body cholesterol homeostasis.
Peter Vollenweider, Arnold von Eckardstein, Gérard Waeber   +2 more
exaly   +2 more sources

Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients

Neuroscience Letters, 2003
The serum concentration of 24S-hydroxycholesterol reflecting brain cholesterol turnover may be a possible marker for neurodegeneration and demyelination in multiple sclerosis.
Charlotte Teunissen, Dieter Lütjohann, Christine D Dijkstra   +2 more
exaly   +2 more sources

Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease

Neuroscience Letters, 2013
Oxysterols are important for cholesterol homeostasis in the brain and may be affected in neurodegenerative diseases. The levels of the brain-derived oxysterol 24S-hydroxycholesterol (24S-OH) have been reported to be markedly reduced in the circulation of
Ingemar Bjorkhem, Per Svenningsson, Steve Meaney   +2 more
exaly   +2 more sources

Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol

Chemistry and Physics of Lipids, 2017
International audienceGlaucoma is a progressive and irreversible blinding neuropathy that is characterized by the loss of retinal ganglion cells (RGCs). Muller Glial Cell (MGC) activation is induced in retinal gliosis.
Catherine Creuzot-Garcher, Alain Bron, Pierre-Henry Gabrielle   +2 more
exaly   +2 more sources