Results 131 to 140 of about 9,716 (212)

Implications of cholesterol and cholesterol-lowering therapy in Alzheimer s disease [PDF]

, 2007
BACKGROUND: Alzheimer s disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia.
Famer, Daniel
core  

Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma

Frontiers in Ophthalmology
Cholesterol is an essential component of cellular membranes, crucial for maintaining their structural and functional integrity. It is especially important for nervous tissues, including the retina, which rely on high amounts of plasma membranes for the ...
Elodie A.Y. Masson, Jeanne Serrano, Jeanne Serrano, Elise Leger-Charnay, Niyazi Acar   +4 more
doaj   +1 more source

24-Hydroxycholesterol 7-Alpha-Hydroxylase [PDF]

, 2020
openaire   +1 more source

Relevance of 24S-hydroxycholesterol as a biomarker of optic neuropathies

, 2010
Purpose: 24S-Hydroxycholesterol is formed by enzymatic oxidation of cholesterol via cholesterol-24S-hydroxylase (CYP46A1) activity in neurons, including retinal ganglion cells and neurons from the inner retina. We investigated whether neurodegeneration could be associated with the release of 24S-hydroxycholesterol in acute neuropathies, and therefore ...
Brétillon, Lionel, Martine, Lucy, Pasquis, Bruno, Fourgeux, Cynthia, Schnebelen, Coralie, Acar, Niyazi, Bjorkhem, Ingemar, Bron, Alain, Creuzot Garcher, Catherine   +8 more
openaire   +2 more sources

Focus on the controversial Role of 24-hydroxycholesterol in Alzheimer's disease

Free Radical Biology and Medicine, 2022
Gamba, Paola, Testa, Gabriella, Staurenghi, Erica, Giannelli, Serena, Sottero, Barbara, Poli, Giuseppe, Leonarduzzi, Gabriella   +6 more
openaire   +2 more sources

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation.

Proceedings of the National Academy of Sciences of the United States of America, 1996
D. Lütjohann, O. Breuer, G. Ahlborg, I. Nennesmo, Å. Sidén, U. Diczfalusy, I. Björkhem   +6 more
semanticscholar   +1 more source

27-Hydroxycholesterol in bile duct tissue promotes cholangiocarcinoma progression through estrogen receptor signaling. [PDF]

Am J Cancer Res
Konishi N, Miyazaki T, Shimoda M, Morishita Y, Honda A, Ikegami T, Suzuki S.   +6 more
europepmc   +1 more source

Efavirenz treatment improves retinal vaso-obliteration and pathological neovascularization in a mouse model of retinopathy of prematurity. [PDF]

Front Med (Lausanne)
Bailey B, Rudd Zhong Manis J, Seth G, Rajpurohit S, Oxenrider A, Martin PM, Jadeja RN, Thounaojam MC.   +7 more
europepmc   +1 more source

Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration. [PDF]

Front Mol Neurosci
Ricci RP, Foo CX, Ronacher K, Cullen CL.
europepmc   +1 more source

A novel sex-specific role for 27-hydroxycholesterol in early-onset schizophrenia. [PDF]

Ann Gen Psychiatry
Sun Z, Liu M, Yan J, Wu Y, Wang H, Li Y, Tang Y, Zheng Y, Li R.   +8 more
europepmc   +1 more source