Results 141 to 150 of about 1,152 (159)

24‐Hydroxycholesterol levels in human brain¹

Journal of Neurochemistry, 1972
24‐Hydroxycholesterol (cerebrosterol, cholest‐5‐ene‐3β;, 24ξ‐diol) occurs at low levels in human (Di Frisco, De Ruggieri and Ercoli, 1953; Ercoli and De Ruggieri, 1953a, 19536; Schubert, Rose and Burger, 1961; Van Lier and Smith, 1969, 1970), equine (Ercoli, Di Frisco and De Ruggieri, 1953a; Ercoli and De Ruggieri, 1953a, 1953b; Fieser, Huang and ...
Leland L. SMITH, D. R. Ray, J. A. Moody, J. D. Wells, J. E. Van Lier   +4 more
openaire   +1 more source

24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells

Molecular and Cellular Endocrinology, 2019
The cholesterol metabolite 24(S)-hydroxycholesterol (24S-OHC) allows cholesterol excretion from the brain and was suggested to be critically involved in physiological as well as neurodegenerative processes. It induces on human neuronal cell cultures a dose dependent toxicity associated with increased reactive oxygen species production.
Cigliano L, Spagnuolo MS, Napolitano G, Iannotta L, FASCIOLO, GIANLUCA, Barone D, Venditti P   +6 more
openaire   +6 more sources

24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells

NeuroReport, 2005
24S-hydroxycholesterol, the primary oxidation product of cholesterol in the brain, plays a key role in cholesterol elimination and homeostasis. While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease.
Piotr, Alexandrov, Jian-Guo, Cui, Yuhai, Zhao, Walter J, Lukiw   +3 more
openaire   +2 more sources

24S-Hydroxycholesterol and Cerebellar Degeneration: Insights from SCA2

The Cerebellum, 2022
Locci S., Nidiaci V., De Stefano N., Leoni V., Mignarri A.   +4 more
openaire   +2 more sources

Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993
Although two hepatic sterol metabolites, 24(S)-hydroxycholesterol and 24(S),25-epoxycholesterol, are thought to be important regulators of cholesterol biosynthesis, nothing is known of their degradation and disposal in liver, nor of the mechanisms that regulate their levels.
Saucier, S E, Kandutsch, A A, Clark, D S, Spencer, T A   +3 more
openaire   +2 more sources

Absolute configurations of 24-hydroxycholesterol and related compounds

Tetrahedron Letters, 1975
Naoyuki Koizumi, Masuo Morisaki, Nobuo Ikekawa, Atsuo Suzuki, Toru Takeshita   +4 more
openaire   +1 more source

24S‐hydroxycholesterol: Cellular effects and variations in brain diseases

Journal of Neurochemistry, 2021
Alejandro O Sodero
exaly  

Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease

Neuroscience Letters, 2013
Ingemar Björkhem, Anita Lövgren-Sandblom, Valerio Leoni   +2 more
exaly  

24-Hydroxycholesterol 7α-hydroxylase

2009
openaire   +1 more source

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

Neuroscience Letters, 2002
Peter Schönknecht, Dieter Lütjohann, Johannes Pantel   +2 more
exaly