Results 101 to 110 of about 6,427 (151)

Glucuronidation et sulfatation du 24S-Hydroxycholestérol : rôles complémentaires dans le contrôle de l'homéostasie de ce marqueur du métabolisme neuronal

, 2018
Le 24S-hydroxycholestérol (24S-OH) est un dérivé oxydé du cholestérol retrouvé dans le plasma chez l’humain. C’est un activateur endogène du Liver-X-Receptor (LXR) et un biomarqueur plasmatique potentiel pour diverses maladies neurodégénératives.
Brousseau, Valérie
core  

Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol

, 2011
Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about 50% of all drugs.
Hanna Nylén (18685588)
core   +1 more source

24S-Hydroxycholesterol Is Associated with Agitation Severity in Patients with Moderate-to-Severe Alzheimer's Disease: Analyses from a Clinical Trial with Nabilone. [PDF]

J Alzheimers Dis, 2019
Ruthirakuhan M, Herrmann N, Andreazza AC, Verhoeff NPLG, Gallagher D, Black SE, Kiss A, Lanctôt KL.   +7 more
europepmc   +1 more source

Cholesterol homeostasis in the brain : importance of 24S-hydroxylation

, 1999
Brain cholesterol is characterized by a very low turnover with very little exchange with lipoproteins in the circulation. We have investigated whether side chain-hydroxylated cholesterol species are important for elimination of cholesterol from the brain.
Dieter Lütjohann (186632)
core   +1 more source

Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke. [PDF]

Stroke
Sun H, Yang T, Simon RP, Xiong ZG, Leng T.   +4 more
europepmc   +1 more source

Metabolic labeling kinetics of brain-derived 24S-hydroxycholesterol in blood in multiple sclerosis: Effects of treatment with the remyelinating antibody rHIgM22. [PDF]

Mult Scler J Exp Transl Clin
Shankaran M, Li KW, Mohammed HA, Protasio J, Fitch M, Matthews M, Nyangau E, Smith G, Klein S, Eisen A, Turner S, Hellerstein MK.   +11 more
europepmc   +1 more source

Lecithin cholesterol acyltransferase esterifies 24s-hydroxycholesterol in cerebrospinal fluid

, 2010
Alteration of cholesterol (Ch) homeostasis is involved in the pathogenesis of neurodegeneration. Astrocyte-derived lecithin cholesterol acyltransferase (LCAT) was recently shown capable of esterifying Ch on ApoE-lipoproteins.
CIGLIANO, LUISA, La Marca V., Pugliese C. R., ABRESCIA, PAOLO, Spagnuolo M. S., Maresca B.   +5 more
core  

Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. [PDF]

BMC Neurosci, 2014
Bandaru VV, Haughey NJ.
europepmc   +1 more source

Excitotoxicity increases the release of 24S-hydroxycholesterol via CYP46A1 activation [PDF]

Mol Neurodegener, 2013
Sodero A, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoe-Pognetto M, Brouwers J, Helms B, Nieswandt B, Voets T, Dotti C.   +11 more
europepmc   +1 more source

Cholesterol at the Center of Alzheimer's Disease: A Unifying Hypothesis on the Pathogenic Mechanism. [PDF]

Molecules
Zhu BT.
europepmc   +1 more source