Results 101 to 110 of about 9,716 (212)

Estimating fetal cholesterol synthesis rates by cord blood analysis in intrauterine growth restriction and normally grown fetuses

Lipids in Health and Disease, 2019
Background Cholesterol is an essential component in human development. In fetuses affected by intrauterine growth restriction (IUGR), fetal blood cholesterol levels are low.
Ulrich Pecks, Verena Bornemann, Anika Klein, Laura Segger, Nicolai Maass, Ibrahim Alkatout, Christel Eckmann-Scholz, Mohamed Elessawy, Dieter Lütjohann   +8 more
doaj   +1 more source

27-Hydroxycholesterol Promotes the Transfer of Astrocyte-Derived Cholesterol to Neurons in Co-cultured SH-SY5Y Cells and C6 Cells

Frontiers in Cell and Developmental Biology, 2020
Abnormality in cholesterol homeostasis in the brain is a feature of Alzheimer’s disease (AD). 27-Hydroxycholesterol (27-OHC) has been identified as a possible biomarker of AD, but its effects on cholesterol metabolism have not been fully characterized ...
Yushan Wang, Xiaona Zhang, Tao Wang, Wen Liu, Lijing Wang, Ling Hao, Mengwei Ju, Rong Xiao   +7 more
doaj   +1 more source

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. [PDF]

, 2015
BackgroundAmyloid-β (Aβ) 42 has been implicated as the initiating molecule in the pathogenesis of Alzheimer's disease (AD); thus, therapeutic strategies that target Aβ42 are of great interest.
Akula, Rajender, Ba, Saritha, Ceballos-Diaz, Carolina, Felsenstein, Kevin M, Golde, Todd E, Hochhaus, Günther, Jung, Joo In, Koo, Edward H, Ladd, Thomas B, Park, Hyo-Jin, Price, Ashleigh R, Ran, Yong, Shapiro, Gideon, Smithson, Lisa A, Tang, Yufei   +14 more
core   +3 more sources

Liver X Receptor α (LXRα) Regulates 5β‐Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 5, Page 456-461, June 2026.
ABSTRACT Steroid‐mediated maternal effects are well‐studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure.
Ryan T. Paitz, Sara E. Waters, Delaney K. Reynolds, Emily M. Drew, Emily P. Harders   +4 more
wiley   +1 more source

Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice [PDF]

, 2015
Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of Huntington's disease (HD), suggesting that locally synthesized, newly formed cholesterol is less available to neurons.
Alessandro Vercelli, Barbara Ruozi, Carlos Cepeda, Claudio Caccia, Costanza Ferrari Bardile, Daniela Belletti, Elena Cattaneo, Eleonora Di Paolo, Elisa Brilli, Flavio Forni, Giovanni Tosi, HDCRG, Jane Y Chen, Maria A Vandelli, Marina M Boido, Marta Valenza, Marullo M, Michael S Levine, Paxinos G, Sethi A, Stefano Di Donato, Trager U, Valerio Leoni   +22 more
core   +4 more sources

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice

eLife, 2016
Previous studies provided evidence for the alteration of brain cholesterol homeostasis in 129.Mecp2-null mice, an experimental model of Rett syndrome. The efficacy of statins in improving motor symptoms and prolonging survival of mutant mice suggested a ...
Claudia Villani, Giuseppina Sacchetti, Renzo Bagnati, Alice Passoni, Federica Fusco, Mirjana Carli, Roberto William Invernizzi   +6 more
doaj   +1 more source

Oxysterols and Their Cellular Effectors [PDF]

, 2012
Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain
Béaslas, Olivier, Nissilä, Eija, Olkkonen, Vesa M.   +2 more
core   +3 more sources

Bile acid synthesis precursors in subjects with genetic hypercholesterolemia negative for LDLR/APOB/PCSK9/APOE mutations. Association with lipids and carotid atherosclerosis [PDF]

, 2017
Some oxysterols are precursors of bile acid synthesis and play an important role in cholesterol homeostasis. However, if they are involved in the pathogeny of genetic hypercholesterolemia has not been previously explored.
Baila-Rueda, L., Bea, A.M., Cenarro, A., Civeira, F., Lamiquiz-Moneo, I., Marco-Benedi, V., Mateo-Gallego, R., Perez-Calahorra, S.   +7 more
core   +2 more sources

Mining for Oxysterols in Cyp7b1^−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

Biomolecules, 2019
Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease.
Anna Meljon, Peter J. Crick, Eylan Yutuc, Joyce L. Yau, Jonathan R. Seckl, Spyridon Theofilopoulos, Ernest Arenas, Yuqin Wang, William J. Griffiths   +8 more
doaj   +1 more source