Results 51 to 60 of about 9,716 (212)
Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1[S]
Journal of Lipid Research, 2014 Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. In addition, the same enzyme is known to further oxidize 24S-hydroxycholesterol to the 24,25- and 24,27 ...
Sandeep Goyal +4 more
doaj +1 more source
Biomarkers for Huntington's disease: an update [PDF]
, 2012 Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative condition caused by a CAG repeat expansion in the gene encoding huntingtin which is characterised by progressive motor impairment, cognitive decline and neuropsychiatric ...
Scahill, RI, Tabrizi, SJ, Wild, EJ
core +1 more source
Journal of Lipid Research, 1997 Extracts of urine and serum from children with cholestatic liver disease were analyzed by fast atom bombardment (FAB) mass spectrometry. About half of all spectra showed a peak at m/z 657, compatible with the presence of a glucuronidated cholestenediol ...
L J Meng +4 more
doaj +1 more source
Brain cholesterol in normal and pathological aging [PDF]
, 2011 Aberrations in cerebral cholesterol homeostasis can lead to severe neurological diseases. Recent findings strengthen the link between brain cholesterol metabolism and factors involved in synaptic plasticity, a process essential for learning and memory ...
Lütjohann, D. (Dieter) +2 more
core +5 more sources
Journal of Lipid Research, 2001 A number of oxysterols have been implicated in metabolic regulation. Key among these are (24S),25-epoxycholesterol and (24S)-hydroxycholesterol, high affinity ligands for the nuclear transcription factor liver X receptor α; 27-hydroxycholesterol, a bile ...
Zhe Zhang +5 more
doaj +1 more source
The role of CYP46A1 and its metabolic product, 24S-hydroxycholesterol, in Neuro 2A cell death
Journal of emerging investigators, 2021 Cholesterol is a major component of neuronal cell membrane and myelin sheath. Therefore, maintaining cholesterol homeostasis is crucial for brain functioning and development. Brain cholesterol is synthesized de novo.
Allen Ni, Xiangning Jiang
semanticscholar +1 more source
Journal of Lipid Research, 2002 Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney +3 more
doaj +1 more source
Cholesterol-Metabolizing Enzyme Cytochrome P450 46A1 as a Pharmacologic Target for Alzheimer’s Disease [PDF]
, 2017 Cytochrome P450 46A1 (CYP46A1 or cholesterol 24-hydroxylase) controls cholesterol elimination from the brain and plays a role in higher order brain functions.
Arajawa, Hiroyuki +8 more
core +1 more source
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MSs⃞
Journal of Lipid Research, 2009 We describe a highly sensitive and specific method for the quantification of key regulatory oxysterols in biological samples. This method is based upon a stable isotope dilution technique by liquid chromatography-tandem mass spectrometry (LC-MS/MS ...
Akira Honda +8 more
doaj +1 more source
, 2009 Purpose. Genetics has made significant contributions to the study of glaucoma over the past few decades. Cholesterol-24S-hydroxylase (CYP46A1) is a cholesterol-metabolizing enzyme that is especially expressed in retinal ganglion cells.
Acar, Niyazi +8 more
core +3 more sources