Results 161 to 170 of about 4,298,356 (197)

Pathogenic Role of 25-Hydroxycholesterol in Cancer Development and Progression

Future Oncology, 2022
Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is a cholesterol derivative that may be formed from cholesterol.
Sura Salman Ejam, Raed Obaid Saleh, Maria Jade Catalan Opulencia, Mazin AA Najm, Aziza Makhmudova, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Moaed E Al-Gazally, Ali Thaeer Hammid, Yasser Fakri Mustafa, Sergushina Elena Sergeevna, Sajad Karampoor, Rasoul Mirzaei   +12 more
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The effect of 25-hydroxycholesterol on accumulation of intracellular calcium

Cell Calcium, 1991
Liposomes prepared with 25-hydroxycholesterol and egg phosphatidylcholine (PC) were incubated with bovine arterial smooth muscle cells for 8 h at 37 degrees C. Cells incubated in the absence of liposomes or with liposomes containing cholesterol and PC were used as controls.
Q, Zhou, S, Jimi, T L, Smith, F A, Kummerow   +3 more
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ChemInform Abstract: A SYNTHESIS OF 25‐HYDROXYCHOLESTEROL

Chemischer Informationsdienst, 1977
AbstractAus den beiden Steroid‐halogeniden (Ia), (Ib) entsteht das substituierte Dithian (IIa), das über das Anion zu (IIb) mit dem entsprechenden Alkylenoxid substituiert werden kann.
W. G. SALMOND, K. D. MAISTO
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Testicular 25-hydroxycholesterol: An alternate substrate for steroidogenesis in reptiles

General and Comparative Endocrinology, 2021
The current study in wall lizards Hemidactylus flaviviridis was designed to ascertain that Leydig cells utilize testicular macrophage-derived 25-hydroxycholesterol (25-HC) for steroidogenesis. Leydig cells (LC) collected from regressed testes when incubated with 25-HC that was obtained from HPLC-eluted fraction of testicular macrophage-conditioned ...
Varsha, Singh, Mamta, Tripathy, Umesh, Rai   +2 more
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Synthesis of 25-hydroxycholesterol from bisnoralcohol

Steroids
25-Hydroxycholesterol not only exhibits various important biological activities but also plays a crucial role in the synthesis of 25-hydroxyvitamin D3. To date, researchers have proposed multiple synthetic routes for 25-hydroxycholesterol. Herein, a novel synthetic method for 25-hydroxycholesterol is described, involving a seven-step reaction that ...
Bu-Luan Liang, Yan-Xin Yue, De-Jie Zhang, Hao-Jie Ni, Xiang-Zhong Gu, Wen-Wei Qiu, Chen-Chen Li   +6 more
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A comparison of solution properties of cholesterol and 25-hydroxycholesterol

Archives of Biochemistry and Biophysics, 1981
Abstract Although 25-hydroxycholesterol is a potent effector of mammalian cellular cholesterol biosynthesis, cholesterol itself is not. In an effort to explain this difference, the critical micellar concentration, liposome-water partition coefficient, and capacity for acyl chain ordering of 25-hydroxycholesterol are measured and compared to those of ...
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Esterification of cholesterol and 25-hydroxycholesterol by rat liver microsomes

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983
The properties of an enzyme in rat liver microsomes was described that catalyzed the formation of 25-hydroxycholesteryl ester in the presence of labeled sterol and oleoyl-CoA. The reaction was similar in several respects to that of cholesteryl ester formation by acyl-CoA: cholesterol acyltransferase.
A H, Lichtenstein, P, Brecher
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On the formation and possible biological role of 25-hydroxycholesterol

Biochimie, 2013
The oxysterol 25-hydroxycholesterol is a widely used compound displaying an array of pharmacological actions in in vitro systems and cell based experimental systems. In spite of the frequent use of this compound over the last few decades and a large number of studies in vitro and in vivo, its mechanism of formation in vivo is still not well understood.
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25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway

The International Journal of Biochemistry & Cell Biology, 2017
Mevalonate pathway deregulation has been observed in several diseases, including Mevalonate kinase deficiency (MKD). MKD is a hereditary auto-inflammatory disorder, due to mutations at mevalonate kinase gene (MVK), encoding mevalonate kinase (MK) enzyme.
Tricarico, Paola Maura, GRATTON, ROSSELLA, Braga, Luca, Celsi, Fulvio, Crovella, Sergio   +4 more
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ChemInform Abstract: A NEW SYNTHESIS OF 25‐HYDROXYCHOLESTEROL

Chemischer Informationsdienst, 1982
AbstractAus dem Alkinol (I) entsteht mit (II) das Zirkon‐Derivat (III), das mit den isomeren Palladium‐Komplexen (IV) und (VIII) zu den Kondensationsprodukten (V) und (VI) bzw. (IX) und (X) führt.
M. RIEDIKER, J. SCHWARTZ
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