Results 161 to 170 of about 3,018,278 (209)

A novel target to turn cold tumors into hot tumors: lysosomal 25-hydroxycholesterol activates AMPKα and immunosuppressive tumor-associated macrophages. [PDF]

Cell Mol Immunol
Liu S, Wu J, Tong X, Huang LH.
europepmc   +1 more source

Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients. [PDF]

Cell Death Discov
Wang T, Gong M, Lu Y, Zhao C, Ling L, Chen J, Ju R.   +6 more
europepmc   +1 more source

25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes. [PDF]

Braz J Med Biol Res
Jiang T, Li Y.
europepmc   +1 more source

Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival. [PDF]

Oxid Med Cell Longev, 2020
Cao Q, Liu Z, Xiong Y, Zhong Z, Ye Q.
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25-hydroxycholesterol promotes brain endothelial dysfunction by remodelling cholesterol metabolism

Tapia VS, Withers SE, Zhou R, Bennington A, Hedley F, El Khouja A, Luka N, Massimo M, Crilly S, Long KR, Lawrence CB, Kasher PR.   +11 more
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Deletion of CH25H and LIPA Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant^‡

Yutuc E, Ghosh A, Abdel-Khalik J, Goenka A, Asgari MA, Lopez-Castejon G, Beaman GM, Wynn RF, Newman WG, Jones SA, Griffiths WJ, Wang Y.   +11 more
europepmc   +1 more source

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25-hydroxycholesterol: Gatekeeper of intestinal IgA

Immunity, 2021
High levels of cholesterol and diets high in fat are associated with immune dysfunction and inflammatory disease. In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA plasma cell differentiation from germinal-center B cells in the Peyer's patches through regulation of the sterol ...
Christopher J M, Piper, Claudia, Mauri
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Investigation on the synthesis of 25-hydroxycholesterol

Steroids, 2014
A very efficient and environmentally benign method has been developed for the synthesis of 25-hydroxycholesterol. The reaction was performed in THF-water (4:1, v/v) using NBS as the brominating agent, followed by the easy reduction of C-Br with lithium aluminum hydride in THF, to yield the final product corresponding to a Markovnikov's rule.
Qian, Zhao, Li, Ji, Guo-Ping, Qian, Jian-Gang, Liu, Zi-Qiang, Wang, Wan-Feng, Yu, Xin-Zhi, Chen   +6 more
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Synthesis of ent-25-hydroxycholesterol

Steroids, 2006
25-Hydroxycholesterol (25-HC) appears to play a role in several important biological processes, including regulating cellular cholesterol levels and promoting apoptosis. However, in most cases the mechanisms by which 25-HC elicits its biological effects are not known.
Emily J, Westover, Douglas F, Covey
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