Results 171 to 180 of about 3,018,278 (209)

25-Hydroxycholesterols in innate and adaptive immunity

Nature Reviews Immunology, 2014
Cholesterol and components of the cholesterol biosynthetic pathway have fundamental roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as important regulators of immune function. This involves effects on the cholesterol biosynthetic pathway and cell membrane properties, which can have antiviral and anti-inflammatory ...
Jason G, Cyster, Eric V, Dang, Andrea, Reboldi, Tangsheng, Yi   +3 more
openaire   +2 more sources

Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25‐Hydroxycholesterol and 25‐Hydroxycholesterol‐3‐sulfate

Lipids, 2010
AbstractDysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25‐hydroxycholesterol‐3‐sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes.
Leyuan, Xu, Qianming, Bai, Daniel, Rodriguez-Agudo, Phillip B, Hylemon, Douglas M, Heuman, William M, Pandak, Shunlin, Ren   +6 more
openaire   +2 more sources

Pathogenic Role of 25-Hydroxycholesterol in Cancer Development and Progression

Future Oncology, 2022
Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is a cholesterol derivative that may be formed from cholesterol.
Sura Salman Ejam, Raed Obaid Saleh, Maria Jade Catalan Opulencia, Mazin AA Najm, Aziza Makhmudova, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Moaed E Al-Gazally, Ali Thaeer Hammid, Yasser Fakri Mustafa, Sergushina Elena Sergeevna, Sajad Karampoor, Rasoul Mirzaei   +12 more
openaire   +2 more sources

A new synthesis of 25-hydroxycholesterol

Tetrahedron Letters, 1981
Abstract A simple (η 3 -allyl)palladium-based synthesis of 25-hydroxycholesterol is described using a dimetallated coupling reagent.
Martin Riediker, Jeffrey Schwartz
openaire   +1 more source

Complementary recessive 25‐hydroxycholesterol‐resistant somatic cell mutants – assay of 25‐hydroxycholesterol binding activity

Journal of Cellular Physiology, 1982
AbstractComplementation analysis of recessive 25‐hydroxycholesterol‐resistant mutants of the CHO‐KI cell shows the existence of at least two complementation groups, one of which is missing a binding activity for 25‐hydroxycholesterol. Both complementation groups are shown to be refractory to inhibition of cellular HMG‐CoA reductase activity and in the ...
M, Sinensky, J, Logel, R, Torget
openaire   +2 more sources

ChemInform Abstract: A SYNTHESIS OF 25‐HYDROXYCHOLESTEROL

Chemischer Informationsdienst, 1977
AbstractAus den beiden Steroid‐halogeniden (Ia), (Ib) entsteht das substituierte Dithian (IIa), das über das Anion zu (IIb) mit dem entsprechenden Alkylenoxid substituiert werden kann.
W. G. SALMOND, K. D. MAISTO
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Testicular 25-hydroxycholesterol: An alternate substrate for steroidogenesis in reptiles

General and Comparative Endocrinology, 2021
The current study in wall lizards Hemidactylus flaviviridis was designed to ascertain that Leydig cells utilize testicular macrophage-derived 25-hydroxycholesterol (25-HC) for steroidogenesis. Leydig cells (LC) collected from regressed testes when incubated with 25-HC that was obtained from HPLC-eluted fraction of testicular macrophage-conditioned ...
Varsha, Singh, Mamta, Tripathy, Umesh, Rai   +2 more
openaire   +2 more sources

The effect of 25-hydroxycholesterol on accumulation of intracellular calcium

Cell Calcium, 1991
Liposomes prepared with 25-hydroxycholesterol and egg phosphatidylcholine (PC) were incubated with bovine arterial smooth muscle cells for 8 h at 37 degrees C. Cells incubated in the absence of liposomes or with liposomes containing cholesterol and PC were used as controls.
Q, Zhou, S, Jimi, T L, Smith, F A, Kummerow   +3 more
openaire   +2 more sources

Synthesis of 25-hydroxycholesterol from bisnoralcohol

Steroids
25-Hydroxycholesterol not only exhibits various important biological activities but also plays a crucial role in the synthesis of 25-hydroxyvitamin D3. To date, researchers have proposed multiple synthetic routes for 25-hydroxycholesterol. Herein, a novel synthetic method for 25-hydroxycholesterol is described, involving a seven-step reaction that ...
Bu-Luan Liang, Yan-Xin Yue, De-Jie Zhang, Hao-Jie Ni, Xiang-Zhong Gu, Wen-Wei Qiu, Chen-Chen Li   +6 more
openaire   +2 more sources

7β-Hydroxycholesterol induces Ca2+ oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells

Atherosclerosis, 2000
In the present study, we characterize the early cytotoxic effects of 7β-hydroxycholesterol, a major cytotoxin in oxidized LDL, in human aortic smooth muscle cells. Within a few minutes after addition, 7β-hydroxycholesterol induced Ca 2+ oscillations with
Mikko P S Ares, Johan Thyberg, Lisa Juntti-Berggren   +2 more
exaly   +2 more sources