Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT Chenodeoxycholic acid (CDCA) is an essential drug for patients with rare metabolic disease cerebrotendinous xanthomatosis (CTX). To ensure continuation of treatment, the Amsterdam UMC hospital pharmacy developed pharmacy compounded CDCA capsules when the authorized CDCA capsules were no longer available for Dutch patients.
Natalja Bouwhuis +9 more
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27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction [PDF]
, 2020 Ying Wang +9 more
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Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT Glycogen storage disease type Ia (GSD Ia) is a rare autosomal recessive inherited disorder of carbohydrate metabolism, caused by a deficiency in glucose 6‐phosphatase‐α (G6PC1). Patients primarily suffer from failure to thrive, hepatomegaly, and severe fasting intolerance, biochemically characterized by hypoketotic, hypoglycemia, and ...
Ruiqi Xiao +7 more
wiley +1 more source
Sterol 27-hydroxylase: expression in human arterial endothelium
Journal of Lipid Research, 1997 Human endothelium obtained from both the aorta and the pulmonary artery has been evaluated for the presence of the messenger RNA coding for the expression of sterol 27-hydroxylase.
A B Reiss +6 more
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A Role for ER-Beta in the Effects of Low-Density Lipoprotein Cholesterol and 27-Hydroxycholesterol on Breast Cancer Progression: Involvement of the IGF Signalling Pathway? [PDF]
, 2021 Reham M. Mashat +3 more
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Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi +2 more
wiley +1 more source
24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)
Journal of Lipid Research, 2000 (24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin +3 more
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Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol
Experimental and Therapeutic Medicine, 2010 The aim of the present study was to identify the possible mechanisms by which certain estradiol receptor (ER)-positive mammary tumor cells remain resistant to treatment with anti-estrogens or inhibitors of local estradiol (E(2)) production. To this end, we compared the proliferative effects on mammary cancer cells of the novel selective ER modulator 27-
Cruz, Pamela +5 more
openaire +6 more sources
Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders
Neuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan +5 more
wiley +1 more source
Figure S3 from 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells [PDF]
, 2023 Shweta Dambal +17 more
openalex +2 more sources