Results 81 to 90 of about 2,669,160 (149)

CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation

Allergology International
Background: 27-Hydroxycholesterol (27-HC) derived from sterol 27-hydroxylase (CYP27A1) has pro-inflammatory biological activity and is associated with oxidative stress and chronic inflammation in COPD.
Tatsunori Ito, Tomohiro Ichikawa, Mitsuhiro Yamada, Yuichiro Hashimoto, Naoya Fujino, Tadahisa Numakura, Yusaku Sasaki, Ayumi Suzuki, Katsuya Takita, Hirohito Sano, Yorihiko Kyogoku, Takuya Saito, Akira Koarai, Tsutomu Tamada, Hisatoshi Sugiura   +14 more
doaj   +1 more source

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1

Journal of Lipid Research, 2013
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem   +9 more
doaj   +1 more source

Increased 27-hydroxycholesterol Plasma Level In Men With Low High Density Lipoprotein-cholesterol May Circumvent Their Reduced Cell Cholesterol Efflux Rate.

, 2015
HDL is considered the most important mechanism for the excretion of intracellular cholesterol. The liver is the only organ capable to metabolize cholesterol into bile acid.
Parra, Eliane S, de Faria, Eliana C, Quintão, Eder C R, Zago, Vanessa S, da Silva, Eliton J, Cazita, Patrícia M, Nakandakare, Edna R, Panzoldo, Natália B, Leança, Camila C, Nunes, Valéria S   +9 more
core   +1 more source

The role of autophagy in survival response induced by 27-hydroxycholesterol in human promonocytic cells [PDF]

, 2018
Autophagy has been shown to be stimulated in advanced atherosclerotic plaques by metabolic stress, inflammation and oxidized lipids. The lack of published studies addressing the potential stimulation of pro-survival autophagy by oxysterols, a family of ...
Testa, G, Paola Gamba, Leonarduzzi, G, Gabriella Leonarduzzi, Vuruşaner Aktaş, Beyza, Gargiulo, Simona, Poli, Giuseppe, Poli, G, Giuseppe Poli, Gamba, P, Gargiulo, S, Testa, Gabriella, Simona Gargiulo, Gamba, Paola, Gabriella Testa, Başağa, Hüveyda, Huveyda Basaga, Beyza Vurusaner, Leonarduzzi, Gabriella   +18 more
core   +1 more source

Separation and Determination of Some of the Main Cholesterol-Related Compounds in Blood by Gas Chromatography-Mass Spectrometry (Selected Ion Monitoring Mode)

Separations, 2018
Oxysterols are metabolites produced in the first step of cholesterol metabolism, which is related to neurodegenerative disorder. They can be detected by testing blood, plasma, serum, or cerebrospinal fluid.
Lucia Valverde-Som, Alegría Carrasco-Pancorbo, Saleta Sierra, Soraya Santana, Cristina Ruiz-Samblás, Natalia Navas, Javier S. Burgos, Luis Cuadros-Rodríguez   +7 more
doaj   +1 more source

Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder

Children
The NR1H2 gene produces the Liver X Receptor Beta (LXRB) protein, which is crucial for brain cholesterol metabolism and neuronal development. However, its involvement in autism spectrum disorder (ASD) remains largely unexplored, aside from animal studies.
Tuğba Menteşe Babayiğit, Güvem Gümüş-Akay, Merve Çikili Uytun, Özlem Doğan, Muhittin A. Serdar, Gökçe Yağmur Efendi, Ayşe Gökçe Erman, Esra Yürümez, Didem Behice Öztop   +8 more
doaj   +1 more source

Trend of 25-hydroxycholesterol and 27-hydroxycholesterol plasma levels in patients affected by active chronic hepatitis B virus infection and inactive carriers

, 2021
Hepatitis B virus (HBV) infection is a global health problem with different immunological phases and therapeutic approaches. The serological condition of inactive carrier (IC) was recently well defined as a clinical and virological stable status, in ...
Di Perri G., Leoni V., Caccia C., Cusato J., Civra A., Poli G., D'Avolio A., Boglione L., Biasi F., Lembo D.   +9 more
core   +1 more source

Voltammetric detection of 27-hydroxycholesterol on boron-doped diamond electrode

The aim of this bachelor thesis was to study the voltammetric behavior of 27-hydroxycholesterol using boron-doped diamond electrode. The influence of several factors on the current response of 27-hydroxycholesterol was investigated: the effect of the ...
Michnová, Kristýna
core   +1 more source

Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells.

Journal of Lipid Research, 1996
The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. 27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than
D A Winegar, J A Salisbury, S S Sundseth, R L Hawke   +3 more
doaj   +1 more source

Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies [PDF]

, 2017
Background The oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth restriction (IUGR) and intrahepatic ...
Ulrich Pecks, Pecks, Ulrich, Laila Najjari, Nicola Kleine-Eggebrecht, Maass, Nicolai, Nicolai Maass, Kleine-Eggebrecht, Nicola, Escher, Genevieve, Mohaupt, Markus, Winkler, Brigitte Sophia, Brigitte Sophia Winkler, Markus Mohaupt, Najjari, Laila, Geneviève Escher   +13 more
core   +1 more source