Results 91 to 100 of about 2,669,160 (149)

The Impact of Brain Cholesterol (24-hydroxycholesterol (24-HC) and 27- hydroxycholesterol (27-HC)) on Invitro Phenotypes of Brain Metastatic Breast Cancer Cells [PDF]

Introduction: Brain metastases is one of the leading causes of breast cancer mortality and rates continue to increase. It has been previously shown that cholesterol metabolism is an important regulator of cancer progression.
Iroabuchi, Cherish
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Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid

Journal of Lipid Research, 2007
Recently, we demonstrated a net blood-to-brain passage of the oxysterol 27-hydroxycholesterol corresponding to 4–5 mg/day. As the steady-state levels of this sterol are only 1–2 μg/g brain tissue, we hypothesized that it is metabolized and subsequently ...
Steve Meaney, Maura Heverin, Ute Panzenboeck, Lena Ekström, Magnus Axelsson, Ulla Andersson, Ulf Diczfalusy, Irina Pikuleva, John Wahren, Wolfgang Sattler, Ingemar Björkhem   +10 more
doaj   +1 more source

26-Hydroxycholesterol: synthesis, metabolism, and biologic activities

Journal of Lipid Research, 1990
Cholest-5-ene-3 beta,26-diol (26-hydroxycholesterol) is synthesized by a mitochondrial P-450 enzyme that appears to be widely distributed in tissues. Together with other C-27 steroid intermediates it is transported to the liver and metabolized to bile ...
NB Javitt
doaj   +1 more source

25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes [PDF]

, 2018
A novel innate immune strategy, involving specific cholesterol oxidation products as effectors, has begun to reveal connections between cholesterol metabolism and immune response against viral infections.
Paola Gamba, Valeria Cagno, Cagno, Valeria, Poli, Giuseppe, Francese, Rachele, Giuseppe Poli, Andrea Civra, Testa, Gabriella, Rachele Francese, Lembo, David, Gamba, Paola, David Lembo, Gabriella Testa, Civra, Andrea   +13 more
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7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis

Journal of Lipid Research, 1997
The report of a novel cytochrome P450 enzyme in mouse hippocampus (cyp7b) with close homology to cholesterol 7 alpha-hydroxylase led us to determine the substrate specificity with respect to 27-hydroxycholesterol, known to be a potent inhibitor of ...
K O Martin, A B Reiss, R Lathe, N B Javitt   +3 more
doaj   +1 more source

A panel of altered blood oxysterols in patients with mild cognitive impairment: A novel combined diagnostic marker

Pharmacological Research
Perturbed cholesterol metabolism may play an important role in the development of dementia and its preclinical stage, mild cognitive impairment (MCI). Oxysterols, the metabolites generated during cholesterol oxidation, also appear to be risk factors for ...
Yu An, Yuandi Xi, Tao Wang, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Kexin Yang, Chengyan Qi, Rong Xiao   +9 more
doaj   +1 more source

Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes

, 2019
Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases associated with an enhancement of lipid peroxidation products such as 7β-hydroxycholesterol (7β-OHC).
Ilham Badreddine (6838493), Claudio Caccia (87835), Mustapha Cherkaoui-Malki (618942), Mohammad Samadi (3028275), Valerio Leoni (440542), Gérard Lizard (3300573), Anne Vejux (6838502), Thomas Nury (6838490), Boubker Nasser (779666), Amira Zarrouk (6838487), Thibault Moreau (765638), Ahmed Salhedine Masmoudi (6838505), Randa Sghaier (6838484), Nora O’Brien (6838496), John J. Mackrill (6838499)   +14 more
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Cholesterol, Oxysterol, Triglyceride, and Coenzyme Q Homeostasis in ALS. Evidence against the Hypothesis That Elevated 27- Hydroxycholesterol Is a Pathogenic Factor

, 2020
High plasma levels of cholesterol have been suggested to be neuroprotective for the degenerative disease amyotrophic lateral sclerosis (ALS) and to be associated with increased survival time.
P, A Parini, Ingemar Bjö Rkhem, Anita Lö Vgren-Sandblom, J, Anna Wuolikainen, P Andersen, Jure Acimovic, Acimovic A Wuolikainen, Loevgren-Sandblom, Paolo Parini, Peter M Andersen   +11 more
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Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry

, 2004
24S-Hydroxycholesterol (24S-OH-Chol) and 27-hydroxycholesterol (27-OH-Chol) are oxidized derivatives of cholesterol and of potential diagnostic interest because their circulating levels may reflect the cholesterol metabolism of the brain and macrophages,
Katharina M. Rentsch, von Eckardstein A, Burkard I, Arnold von Eckardstein, Rentsch KM, Ines Burkard   +5 more
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Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

, 2000
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance.
Siden, A, Bjorkhem, I, Lutjohann, D, Bretillon, L, Wahlund, L O, Minthon, Lennart, Diczfalusy, U, Crisby, M, Hillert, J, Groth, C G   +9 more
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