Results 91 to 100 of about 1,842,116 (207)

HvarAKR1B1‐mediated tolerance in Hippodamia variegata: Deciphering the metabolic adaptation and fitness costs under prolonged starvation

Pest Management Science, EarlyView.
Starvation stress significantly affected the growth and development of Hippodamia variegata. Combined transcriptome and metabolome analysis and RNA interference verification revealed that HvarAKR1B1 may be involved in the response of Hippodamia variegata to starvation stress.
Bing‐mei Song, De‐qin Hu, Yuan Li, Wang‐quan Jiao, Xiao‐li Ma, Hong‐sheng Pan   +5 more
wiley   +1 more source

27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype

Oncology Reports, 2011
A decrease in the expression of E-cadherin and β-catenin, paralleling the loss of adherens junction complex, was observed in MCF7 cells exposed for longer than 48 h to 2 µM 27-hydroxycholesterol (27OHC), indicating an epithelial-mesenchymal transition (EMT).
Torres, Cristian G., Ramírez, María Eugenia, Cruz, Pamela, Epuñán, María José, Valladares Boasi, Luis, Sierralta, Walter D.   +5 more
openaire   +6 more sources

The role of autophagy in survival response induced by 27-hydroxycholesterol in human promonocytic cells [PDF]

, 2018
Autophagy has been shown to be stimulated in advanced atherosclerotic plaques by metabolic stress, inflammation and oxidized lipids. The lack of published studies addressing the potential stimulation of pro-survival autophagy by oxysterols, a family of ...
Testa, G, Paola Gamba, Leonarduzzi, G, Gabriella Leonarduzzi, Vuruşaner Aktaş, Beyza, Gargiulo, Simona, Poli, Giuseppe, Poli, G, Giuseppe Poli, Gamba, P, Gargiulo, S, Testa, Gabriella, Simona Gargiulo, Gamba, Paola, Gabriella Testa, Başağa, Hüveyda, Huveyda Basaga, Beyza Vurusaner, Leonarduzzi, Gabriella   +18 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Trend of 25-hydroxycholesterol and 27-hydroxycholesterol plasma levels in patients affected by active chronic hepatitis B virus infection and inactive carriers

, 2021
Hepatitis B virus (HBV) infection is a global health problem with different immunological phases and therapeutic approaches. The serological condition of inactive carrier (IC) was recently well defined as a clinical and virological stable status, in ...
Di Perri G., Leoni V., Caccia C., Cusato J., Civra A., Poli G., D'Avolio A., Boglione L., Biasi F., Lembo D.   +9 more
core   +1 more source

7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier

Journal of Lipid Research, 2014
There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA).
Ahmed Saeed, Federico Floris, Ulla Andersson, Irina Pikuleva, Anita Lövgren-Sandblom, Maria Bjerke, Martin Paucar, Anders Wallin, Per Svenningsson, Ingemar Björkhem   +9 more
doaj   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes

, 1995
The major relation existing between cell growth and cholesterol homeostasis prompted us to investigate the effect of 26-aminocholesterol (26-NH2), 27-hydroxycholesterol (27-OH), and 25-hydroxycholesterol (25-OH) on these cellular events.
R. Paoletti, D. Verri, P. Quarato, M. Raiteri, A. Corsini, R. Fumagalli   +5 more
core   +1 more source

Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
This study uses metabolomics to compare urine, plasma and serum metabolite profiles across breast cancer, benign breast disease, symptomatic and healthy controls. Significant metabolic differences—especially in amino acids—were found between BC and other groups, with moderate correlations across biofluids, suggesting potential for non‐invasive BC ...
Nur Aimi Aliah Zainurin, Anuradha U. K. H. Bambarandhage, Michelle Moreno Escalona, Dimitra Ivanova, Tim Gate, Helen Tench, Manfred Beckman, Helen Phillips, Mandana Pennick, Luis A. J. Mur   +9 more
wiley   +1 more source

Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer [PDF]

Endocrine-Related Cancer, 2017
The impact of systemic 27-hydroxycholesterol (27HC) and intratumoral CYP27A1 expression on pathobiology and clinical response to statins in breast cancer needs clarification. 27HC is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis.
Siker, Kimbung, Ching-Yi, Chang, Pär-Ola, Bendahl, Laura, Dubois, J Will, Thompson, Donald P, McDonnell, Signe, Borgquist   +6 more
openaire   +2 more sources