Results 111 to 120 of about 1,842,116 (207)

Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes

, 2019
Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases associated with an enhancement of lipid peroxidation products such as 7β-hydroxycholesterol (7β-OHC).
Ilham Badreddine (6838493), Claudio Caccia (87835), Mustapha Cherkaoui-Malki (618942), Mohammad Samadi (3028275), Valerio Leoni (440542), Gérard Lizard (3300573), Anne Vejux (6838502), Thomas Nury (6838490), Boubker Nasser (779666), Amira Zarrouk (6838487), Thibault Moreau (765638), Ahmed Salhedine Masmoudi (6838505), Randa Sghaier (6838484), Nora O’Brien (6838496), John J. Mackrill (6838499)   +14 more
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Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: Protective effect of N-acetyl-cysteine [PDF]

, 2014
An abnormal accumulation of cholesterol oxidation products in the brain of patients with Alzheimer's disease (AD) would further link an impaired cholesterol metabolism in the pathogenesis of the disease.
Guglielmotto, Michela, Luigi Iuliano, ZERBINATI, CHIARA, Gamba, Paola Francesca, Poli, Giuseppe, Giuseppe Poli, Mauro, Alessandro, Alessandro Mauro, Tamagno, Elena, Biasi, Fiorella, Testa, Gabriella, Debora Monteleone, Monteleone, Debora, Leonarduzzi, Gabriella Marisa, Paola Gamba, Chiara Zerbinati, Elena Tamagno, Gabriella Leonarduzzi, Gargiulo, Simona, Fiorella Biasi, Giorgio Giaccone, Simona Gargiulo, IULIANO, Luigi, Gabriella Testa, Michela Guglielmotto   +24 more
core   +1 more source

Voltammetric detection of 27-hydroxycholesterol on boron-doped diamond electrode

The aim of this bachelor thesis was to study the voltammetric behavior of 27-hydroxycholesterol using boron-doped diamond electrode. The influence of several factors on the current response of 27-hydroxycholesterol was investigated: the effect of the ...
Michnová, Kristýna
core   +1 more source

Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells.

Journal of Lipid Research, 1996
The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. 27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than
D A Winegar, J A Salisbury, S S Sundseth, R L Hawke   +3 more
doaj   +1 more source

Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies

, 2017
Background The oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth restriction (IUGR) and intrahepatic ...
Ulrich Pecks, Pecks, Ulrich, Laila Najjari, Nicola Kleine-Eggebrecht, Maass, Nicolai, Nicolai Maass, Kleine-Eggebrecht, Nicola, Escher, Genevieve, Mohaupt, Markus, Winkler, Brigitte Sophia, Brigitte Sophia Winkler, Markus Mohaupt, Najjari, Laila, Geneviève Escher   +13 more
core   +1 more source

26-Hydroxycholesterol: synthesis, metabolism, and biologic activities

Journal of Lipid Research, 1990
Cholest-5-ene-3 beta,26-diol (26-hydroxycholesterol) is synthesized by a mitochondrial P-450 enzyme that appears to be widely distributed in tissues. Together with other C-27 steroid intermediates it is transported to the liver and metabolized to bile ...
NB Javitt
doaj   +1 more source

Cholesterol, Oxysterol, Triglyceride, and Coenzyme Q Homeostasis in ALS. Evidence against the Hypothesis That Elevated 27- Hydroxycholesterol Is a Pathogenic Factor

, 2020
High plasma levels of cholesterol have been suggested to be neuroprotective for the degenerative disease amyotrophic lateral sclerosis (ALS) and to be associated with increased survival time.
P, A Parini, Ingemar Bjö Rkhem, Anita Lö Vgren-Sandblom, J, Anna Wuolikainen, P Andersen, Jure Acimovic, Acimovic A Wuolikainen, Loevgren-Sandblom, Paolo Parini, Peter M Andersen   +11 more
core  

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

, 2000
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance.
Siden, A, Bjorkhem, I, Lutjohann, D, Bretillon, L, Wahlund, L O, Minthon, Lennart, Diczfalusy, U, Crisby, M, Hillert, J, Groth, C G   +9 more
core   +1 more source

Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder

Children
The NR1H2 gene produces the Liver X Receptor Beta (LXRB) protein, which is crucial for brain cholesterol metabolism and neuronal development. However, its involvement in autism spectrum disorder (ASD) remains largely unexplored, aside from animal studies.
Tuğba Menteşe Babayiğit, Güvem Gümüş-Akay, Merve Çikili Uytun, Özlem Doğan, Muhittin A. Serdar, Gökçe Yağmur Efendi, Ayşe Gökçe Erman, Esra Yürümez, Didem Behice Öztop   +8 more
doaj   +1 more source

Survival signals induced by low concentrations of 27-hydroxycholesterol in human monocytic cells via ERK activation

, 2012
Oxysterols are oxidized derivatives of cholesterol, most likely contributing to the development of atherosclerosis. On the basis of the clear findings by previous workers about oxysterol-mediated induction of survival pathways aside that of death ...
Vuruşaner Aktaş, Beyza, Poli, Giuseppe, Başağa, Hüveyda   +2 more
core   +1 more source