Results 121 to 130 of about 1,842,116 (207)

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid

Journal of Lipid Research, 2007
Recently, we demonstrated a net blood-to-brain passage of the oxysterol 27-hydroxycholesterol corresponding to 4–5 mg/day. As the steady-state levels of this sterol are only 1–2 μg/g brain tissue, we hypothesized that it is metabolized and subsequently ...
Steve Meaney, Maura Heverin, Ute Panzenboeck, Lena Ekström, Magnus Axelsson, Ulla Andersson, Ulf Diczfalusy, Irina Pikuleva, John Wahren, Wolfgang Sattler, Ingemar Björkhem   +10 more
doaj   +1 more source

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation

, 2017
Hypercholesterolemia is associated with cognitively deteriorated states. Here, we show that excess 27-hydroxycholesterol (27-OH), a cholesterol metabolite passing from the circulation into the brain, reduced in vivo brain glucose uptake, GLUT4 expression,
Laura Mateos, Zeina Ali, Irina Savitcheva, Eric Westman, Muhammad-Al-Mustafa Ismail, Paula Merino-Serrais, Angel Cedazo-Mínguez, Maria Lodeiro, Eran Leitersdorf, Ingemar Björkhem, Balázs Gulyás, Lars Olof-Wahlund, Silvia Maioli, Bengt Winblad   +13 more
core   +1 more source

A panel of altered blood oxysterols in patients with mild cognitive impairment: A novel combined diagnostic marker

Pharmacological Research
Perturbed cholesterol metabolism may play an important role in the development of dementia and its preclinical stage, mild cognitive impairment (MCI). Oxysterols, the metabolites generated during cholesterol oxidation, also appear to be risk factors for ...
Yu An, Yuandi Xi, Tao Wang, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Kexin Yang, Chengyan Qi, Rong Xiao   +9 more
doaj   +1 more source

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

, 2013
SummaryTo date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice.
Yuhanna, Ivan S., Chieko Mineo, Yang Xie, Jeffrey G. McDonald, Euhus, David M., David M. Euhus, Tomonori Ishikawa, Sirianni, Rosa, Tang, Hao, Hao Tang, Brekken, Rolf A., Qian Wu, Thompson, Bonne, Umetani, Michihisa, Girard, Luc, Ivan S. Yuhanna, Rosa Sirianni, Ishikawa, Tomonori, Shaul, Philip W., Philip W. Shaul, Wu, Qian, Xie, Yang, Michihisa Umetani, Bonne Thompson, Rolf A. Brekken, McDonald, Jeffrey G., Luc Girard, Mineo, Chieko   +27 more
core   +1 more source

Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals

, 2009
The present study assessed the association between serum 24S-hydroxycholesterol (24S-OH-Chol) and 27-hydroxycholesterol (27-OH-Chol) and hippocampal volumes in 69 middle-aged cognitively normal individuals.
Schmidt-Samoa, Carsten, Koschack, Janka, Irle, Eva, Luetjohann, Dieter   +3 more
core   +1 more source

The Role of 27-Hydroxycholesterol in the Pathogenesis of Bronchial Asthma [PDF]

TP111. TP111 ASTHMA AND ALLERGIC RESPONSES: CELLULAR AND MOLECULAR PATHWAYS, 2021
T. Ito, T. Ichikawa, K. Takita, M. Yamada, M. Ichinose, H. Sugiura   +5 more
openaire   +1 more source

Lovastatin reversed the enhanced sphingomyelin caused by 27-hydroxycholesterol in cultured vascular endothelial cells

, 2016
Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Allan Luo, Zhou, Qi, Fred A Kummerow, Kummerow, Fred A, Luo, Allan, Qi Zhou   +5 more
core   +1 more source

27-Hydroxycholesterol [PDF]

, 2020
openaire   +1 more source

The Impact of Brain Cholesterol (24-hydroxycholesterol (24-HC) and 27- hydroxycholesterol (27-HC)) on Invitro Phenotypes of Brain Metastatic Breast Cancer Cells

Introduction: Brain metastases is one of the leading causes of breast cancer mortality and rates continue to increase. It has been previously shown that cholesterol metabolism is an important regulator of cancer progression.
Iroabuchi, Cherish
core   +1 more source

27-Hydroxycholesterol represses G9a expression via oestrogen receptor alpha in breast cancer. [PDF]

J Cell Mol Med, 2023
Vini R, Lekshmi A, Ravindran S, Thulaseedharan JV, Sujathan K, Rajavelu A, Sreeja S.   +6 more
europepmc   +1 more source