Results 111 to 120 of about 11,352 (188)

Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder

Children
The NR1H2 gene produces the Liver X Receptor Beta (LXRB) protein, which is crucial for brain cholesterol metabolism and neuronal development. However, its involvement in autism spectrum disorder (ASD) remains largely unexplored, aside from animal studies.
Tuğba Menteşe Babayiğit, Güvem Gümüş-Akay, Merve Çikili Uytun, Özlem Doğan, Muhittin A. Serdar, Gökçe Yağmur Efendi, Ayşe Gökçe Erman, Esra Yürümez, Didem Behice Öztop   +8 more
doaj   +1 more source

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid

Journal of Lipid Research, 2007
Recently, we demonstrated a net blood-to-brain passage of the oxysterol 27-hydroxycholesterol corresponding to 4–5 mg/day. As the steady-state levels of this sterol are only 1–2 μg/g brain tissue, we hypothesized that it is metabolized and subsequently ...
Steve Meaney, Maura Heverin, Ute Panzenboeck, Lena Ekström, Magnus Axelsson, Ulla Andersson, Ulf Diczfalusy, Irina Pikuleva, John Wahren, Wolfgang Sattler, Ingemar Björkhem   +10 more
doaj   +1 more source

Impact of the sterol 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol on tumor-pathological features, prognosis and response to statin treatment in breast cancer [PDF]

, 2017
Siker Kimbung, Ching‐yi Chang, Pär‐Ola Bendahl, Laura G. Dubois, Will J. Thompson, Donald P. McDonnell, Signe Borgquist   +6 more
openalex   +1 more source

7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis

Journal of Lipid Research, 1997
The report of a novel cytochrome P450 enzyme in mouse hippocampus (cyp7b) with close homology to cholesterol 7 alpha-hydroxylase led us to determine the substrate specificity with respect to 27-hydroxycholesterol, known to be a potent inhibitor of ...
K O Martin, A B Reiss, R Lathe, N B Javitt   +3 more
doaj   +1 more source

Figure S5 from 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells

, 2023
Shweta Dambal, Mahmoud A. Alfaqih, Sergio Sanders, Erick Maravilla, Adela Ramírez‐Torres, Gloria C. Galván, Mariana Reis-Sobreiro, Mirja Rotinen, Lucy M. Driver, Matthew S. Behrove, Tijana Jovanović‐Talisman, Junhee Yoon, Sungyong You, James Turkson, Jen‐Tsan Chi, Marc Freeman, Everardo Macias, Stephen J. Freedland   +17 more
openalex   +1 more source

A panel of altered blood oxysterols in patients with mild cognitive impairment: A novel combined diagnostic marker

Pharmacological Research
Perturbed cholesterol metabolism may play an important role in the development of dementia and its preclinical stage, mild cognitive impairment (MCI). Oxysterols, the metabolites generated during cholesterol oxidation, also appear to be risk factors for ...
Yu An, Yuandi Xi, Tao Wang, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Kexin Yang, Chengyan Qi, Rong Xiao   +9 more
doaj   +1 more source

27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells [PDF]

, 2001
Xuan Fu, John G. Menke, Yu‐Li Chen, Gaochao Zhou, Karen L. MacNaul, Samuel D. Wright, Carl P. Sparrow, Erik Lund   +7 more
openalex   +1 more source

The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha [PDF]

, 2014
Michihisa Umetani, Pritam Ghosh, Tomonori Ishikawa, Junko Umetani, Mohamed H. Ahmed, Chieko Mineo, Philip W. Shaul   +6 more
openalex   +1 more source

27-Hydroxycholesterol Promotes the Transfer of Astrocyte-Derived Cholesterol to Neurons in Co-cultured SH-SY5Y Cells and C6 Cells [PDF]

, 2020
Yushan Wang, Xiaona Zhang, Tao Wang, Wen Liu, Lijing Wang, Ling Hao, Mengwei Ju, Rong Xiao   +7 more
openalex   +1 more source

The Cytotoxicity of 27-Hydroxycholesterol in MCF-7 and MDA-MB-231. [PDF]

Adv Biomed Res, 2023
Rashidi Alavijeh M, Etesami H, Dehghan A, Babajani A, Haghjooy Javanmard S.   +4 more
europepmc   +1 more source