Massively parallel functional annotation of 3' untranslated regions. [PDF]
Nat Biotechnol, 2014 Functional characterization of noncoding sequences is crucial for understanding the human genome and learning how genetic variation contributes to disease. 3' untranslated regions (UTRs) are an important class of noncoding sequences, but their functions remain largely uncharacterized.
Zhao W +5 more
europepmc +7 more sources
Expression of distinct RNAs from 3' untranslated regions. [PDF]
Nucleic Acids Res, 2011 The 3' untranslated regions (3'UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers of 3'UTRs in human, mouse and fly are also expressed separately from the associated protein-coding sequences to which they are normally linked, likely by post-transcriptional cleavage.
Mercer TR +12 more
europepmc +9 more sources
Alternative polyadenylation produces multiple 3’ untranslated regions of odorant receptor mRNAs in mouse olfactory sensory neurons [PDF]
BMC Genomics, 2019 Background Odorant receptor genes constitute the largest gene family in mammalian genomes and this family has been extensively studied in several species, but to date far less attention has been paid to the characterization of their mRNA 3′ untranslated ...
Mohamed Doulazmi +4 more
doaj +4 more sources
MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers. [PDF]
PLoS ONE, 2012 MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer.
Georgina L Ryland +9 more
doaj +3 more sources
3′untranslated regions: regulation at the end of the road [PDF]
Current Genetics, 2018 Post-transcriptional gene regulation in bacteria plays a major role in the adaptation of bacterial cells to the changing conditions encountered in the environment. In bacteria, most of the regulation at the level of mRNA seems to be targeting the 5'untranslated regions where accessibility to the ribosome-binding site can be modulated to alter gene ...
Youssef El Mouali, Carlos Balsalobre
openaire +4 more sources
Genetic Polymorphisms in the 3′-Untranslated Regions of SMAD5, FN3KRP, and RUNX-1 Are Associated with Recurrent Pregnancy Loss [PDF]
Biomedicines, 2022 Recurrent pregnancy loss (RPL) is typically defined as two or more consecutive pregnancy losses prior to 20 weeks of gestation. Although the causes of idiopathic RPL are not completely understood, vascular development and glucose concentration were ...
Min-Jung Kwon +7 more
doaj +2 more sources
5’ and 3’ untranslated regions strongly enhance performance of geminiviral replicons in Nicotiana benthamiana leaves [PDF]
Frontiers in Plant Science, 2016 We previously reported a recombinant protein production system based on a geminivirus replicon that yields high levels of vaccine antigens and monoclonal antibodies in plants.
Andrew G. Diamos +2 more
doaj +2 more sources
The 5′ and 3′ Untranslated Regions of the Japanese Encephalitis Virus (JEV): Molecular Genetics and Higher Order Structures [PDF]
Frontiers in Microbiology, 2021 The untranslated region (UTRs) of viral genome are important for viral replication and immune modulation. Japanese encephalitis virus (JEV) is the most significant cause of epidemic encephalitis worldwide.
Hong Liu +4 more
doaj +2 more sources
Highly accessible AU-rich regions in 3' untranslated regions are hotspots for binding of regulatory factors. [PDF]
PLoS Computational Biology, 2017 Post-transcriptional regulation is regarded as one of the major processes involved in the regulation of gene expression. It is mainly performed by RNA binding proteins and microRNAs, which target RNAs and typically affect their stability.
Mireya Plass +2 more
doaj +2 more sources
Dom34 rescues ribosomes in 3' untranslated regions. [PDF]
Cell, 2014 Ribosomes that stall before completing peptide synthesis must be recycled and returned to the cytoplasmic pool. The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is unknown. Here, we extend ribosome profiling methodology to reveal a high-resolution molecular characterization
Guydosh NR, Green R.
europepmc +4 more sources