Results 21 to 30 of about 136,200 (251)

Improving plant transient expression through the rational design of synthetic 5′ and 3′ untranslated regions [PDF]

Plant Methods, 2019
Background The growing field of plant molecular farming relies on expression vectors that allow high yields of recombinant proteins to be produced through transient gene expression.
Hadrien Peyret, James K. M. Brown, George P. Lomonossoff   +2 more
doaj   +2 more sources

Structures and Functions of the 3′ Untranslated Regions of Positive-Sense Single-Stranded RNA Viruses Infecting Humans and Animals [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
The 3′ untranslated region (3′ UTR) of positive-sense single-stranded RNA [ssRNA(+)] viruses is highly structured. Multiple elements in the region interact with other nucleotides and proteins of viral and cellular origin to regulate various aspects of ...
Yuanzhi Liu, Yuanzhi Liu, Yuanzhi Liu, Yu Zhang, Yu Zhang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Renyong Jia, Renyong Jia, Renyong Jia, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Shun Chen, Shun Chen, Shun Chen, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, XinXin Zhao, XinXin Zhao, XinXin Zhao, Juan Huang, Juan Huang, Juan Huang, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Qun Gao, Qun Gao, Qun Gao, Yin Wang, Zhiwen Xu, Zhengli Chen, Ling Zhu, Qihui Luo, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Bin Tian, Bin Tian, Leichang Pan, Leichang Pan, Xiaoyue Chen, Xiaoyue Chen, Xiaoyue Chen   +66 more
doaj   +2 more sources

Properties of untranslated regions of the S. cerevisiae genome

BMC Genomics, 2009
Background During evolution selection forces such as changing environments shape the architecture of genomes. The distribution of genes along chromosomes and the length of intragenic regions are basic genomic features known to play a major role in the ...
Tuller Tamir, Ruppin Eytan, Kupiec Martin   +2 more
doaj   +2 more sources

Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs [PDF]

Frontiers in Genetics, 2019
The length of untranslated regions at the 3′ end of transcripts (3′UTRs) is regulated by alternate polyadenylation (APA). 3′UTRs contain regions that harbor binding motifs for regulatory molecules. However, the mechanisms that coordinate the 3′UTR length
Benjamin J. Harrison, Benjamin J. Harrison, Benjamin J. Harrison, Juw Won Park, Juw Won Park, Cynthia Gomes, Jeffrey C. Petruska, Jeffrey C. Petruska, Jeffrey C. Petruska, Matthew R. Sapio, Michael J. Iadarola, Julia H. Chariker, Julia H. Chariker, Eric C. Rouchka, Eric C. Rouchka   +14 more
doaj   +2 more sources

A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines [PDF]

Vaccines
Background/Objectives: The recent COVID-19 pandemic caused by SARS-CoV-2 infection has highlighted the need for protocols for rapid development of efficient screening methods to search for the optimal mRNA vaccine structures against mutable viral agents.
Maria Rubtsova, Yuliana Mokrushina, Dmitry Andreev, Maria Poteshnova, Nikita Shepelev, Mariya Koryagina, Ekaterina Moiseeva, Diana Malabuiok, Yury Prokopenko, Stanislav Terekhov, Aleksander Chernov, Elena Vodovozova, Ivan Smirnov, Olga Dontsova, Alexander Gabibov, Yury Rubtsov   +15 more
doaj   +2 more sources

Toward a systematic understanding of mRNA 3' untranslated regions. [PDF]

Proc Am Thorac Soc, 2011
Abstract Messenger RNAs (mRNAs) contain prominent untranslated regions (UTRs) that are increasingly recognized to play roles in mRNA processing, transport, stability, and translation. 3′ UTRs are believed to harbor recognition sites for a diverse set of RNA-binding proteins that regulate gene expression as well as most active microRNA
Zhao W, Blagev D, Pollack JL, Erle DJ.
europepmc   +4 more sources

3' Untranslated regions mediate transcriptional interference between convergent genes both locally and ectopically in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2014
Paired sense and antisense (S/AS) genes located in cis represent a structural feature common to the genomes of both prokaryotes and eukaryotes, and produce partially complementary transcripts.
Luwen Wang, Ning Jiang, Lin Wang, Ou Fang, Lindsey J Leach, Xiaohua Hu, Zewei Luo   +6 more
doaj   +2 more sources

Predicting the Genes Regulated by MicroRNAs via Binding Sites in the 3' Untranslated and Coding Regions [PDF]

CHIMIA, 2014
MicroRNAs form one of the groups of small noncoding RNA molecules that have completely changed our understanding of gene regulatory networks. Because microRNAs have been discovered only relatively recently, most of their functions remain unknown,
Jiří Vaníček
doaj   +2 more sources

The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity

Frontiers in Microbiology, 2018
Viral genomes have evolved to maximize their potential of overcoming host defense mechanisms and to induce a variety of disease syndromes. Structurally, a genome of a virus consists of coding and noncoding regions, and both have been shown to contribute ...
Anna Kloc, Devendra K. Rai, Elizabeth Rieder   +2 more
doaj   +2 more sources

Translational control of mRNAs by 3'-Untranslated region binding proteins [PDF]

BMB Reports, 2017
Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3'-untranslated regions (UTRs) of mRNAs. mRNA 3'-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay.
Yamashita, Akio, Takeuchi, Osamu
openaire   +4 more sources