Multi‐level metabolic engineering of Escherichia coli for high‐titer biosynthesis of 2′‐fucosyllactose and 3‐fucosyllactose [PDF]
Microbial Biotechnology, 2022 Fucosyllactoses (FL), including 2′‐fucosyllactose (2′‐FL) and 3‐fucosyllactose (3‐FL), have garnered considerable interest for their value in newborn formula and pharmaceuticals.
Mengli Li +5 more
doaj +3 more sources
Safety of 3‐fucosyllactose (3‐FL) produced by a derivative strain of Escherichia coli K‐12 DH1 as a novel food pursuant to Regulation (EU) 2015/2283 [PDF]
EFSA Journal, 2023 Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 3‐fucosyllactose (3‐FL) as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) +29 more
doaj +2 more sources
Safety of 3‐fucosyllactose (3‐FL) produced by a derivative strain of Escherichia coli BL21 (DE3) as a Novel Food pursuant to Regulation (EU) 2015/2283 [PDF]
EFSA Journal, 2022 Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 3‐fucosyllactose (3‐FL) as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) +27 more
doaj +2 more sources
Safety of 3‐FL (3‐Fucosyllactose) as a novel food pursuant to Regulation (EU) 2015/2283 [PDF]
EFSA Journal, 2021 Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 3‐fucosyllactose (3‐FL) as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) +26 more
doaj +2 more sources
Ovalbumin-Induced Epithelial Activation Directs Monocyte-Derived Dendritic Cells to Instruct Type 2 Inflammation in T Cells Which Is Differentially Modulated by 2′-Fucosyllactose and 3-Fucosyllactose [PDF]
Journal of Innate Immunity, 2022 Allergic sensitization starts with epithelial cell activation driving dendritic cells (DCs) to instruct T helper 2 (Th2) cell polarization. Food allergens trigger intestinal epithelial cell (IEC) activation.
Marit Zuurveld +6 more
doaj +2 more sources
Strain-specific strategies of 2′-fucosyllactose, 3-fucosyllactose, and difucosyllactose assimilation by Bifidobacterium longum subsp. infantis Bi-26 and ATCC 15697 [PDF]
Scientific Reports, 2020 Human milk provides essential nutrients for infant nutrition. A large proportion of human milk is composed of human milk oligosaccharides (HMOs), which are resistant to digestion by the infant. Instead, HMOs act as a bioactive and prebiotic enriching HMO-
Bryan E. Zabel +6 more
doaj +2 more sources
Safety of the extension of use of 3‐fucosyllactose (3‐FL) as a novel food pursuant to Regulation (EU) 2015/2283 [PDF]
EFSA JournalFollowing a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of the extension of use of 3‐fucosyllactose (3‐FL) as a novel food (NF) pursuant to ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) +28 more
doaj +2 more sources
Transglycosylation Capabilities of Wild‐Type α‐l‐Fucosidase iso1 from Paenibacillus thiaminolyticus and Its Engineered Mutants: Preparation of Fucosylated Oligosaccharides [PDF]
Microbial BiotechnologyTo enhance the yield of l‐fucosylated molecules synthesized via transfucosylation, we employed α‐l‐transfucosidases, enzymes engineered from α‐l‐fucosidases to favour transglycosylation over hydrolysis.
Patricie Vodičková +8 more
doaj +2 more sources
Human milk oligosaccharide composition, concentrations and association with maternal factors in the multi-ethnic Asian GUSTO cohort [PDF]
Frontiers in NutritionPurposeTo investigate the human milk oligosaccharide (HMO) composition, longitudinal change and the influence of maternal factors in a multi-ethnic Asian cohort.MethodsIn the prospective GUSTO mother-offspring cohort, maternal sociodemographic, genetic ...
Han Zhang +30 more
doaj +2 more sources
Longitudinal changes of human milk oligosaccharides in Japan and their associations with maternal or infant characteristics [PDF]
Frontiers in NutritionIntroductionHuman milk oligosaccharides (HMOs) are the third most abundant solid component in human milk and contribute to infant gut microbiota development, immune maturation, and neurodevelopment.
Naoko Higuchi +6 more
doaj +2 more sources