Results 81 to 90 of about 88,507,907 (147)

Fucoidan But Not 2′-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae

, 2021
Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (
Mohamad Eshaghi Gorji, Zhiyuan Gong, Malcolm Turk Hsern Tan, Dan Li, Yan Li   +4 more
core   +1 more source

Substrate specificity and transfucosylation activity of GH29 α-l-fucosidases for enzymatic production of human milk oligosaccharides [PDF]

, 2018
Human milk oligosaccharides (HMOs) constitute a unique family of bioactive lactose-based molecules present in human breast milk. HMOs are of major importance for infant health and development but also virtually absent from bovine milk used for infant ...
Mattias Raae Gedde, Zeuner, Birgitte, Holck, Jesper, Meyer, Anne S., Anne S. Meyer, Lezyk, Mateusz, Jan Muschiol, Jørn Dalgaard Mikkelsen, Carsten Jers, Muschiol, Jan, Birgitte Zeuner, Gedde, Mattias Raae, Jers, Carsten, Mikkelsen, Jørn Dalgaard, Jesper Holck, Mateusz Lezyk   +15 more
core   +1 more source

Bioinformatics Analysis, Heterologous Expression and Activity Analysis of α-L-Fucosidase AlfB [PDF]

Shipin Kexue
To investigate the structural properties and catalytic activity of α-L-fucosidases belonging to the GH29A family, the gene coding for the AlfB enzyme from Lactobacillus rhamnosus GG was obtained from the NCBI database.
LI Qiaohui, WEN Miao, YU Hang, SU Qian, MENG Xiangchen
doaj   +1 more source

Structure-dependent degradation of milk oligosaccharides by newly isolated intestinal commensal bacterial strains from suckling piglets and rabbits

BMC Microbiology
Background Mammalian milk oligosaccharides serve as the first natural prebiotics for newborns, promoting the development of a beneficial gut microbiota. The ability of bacteria to use these complex sugars depends on their structure, but data are limited ...
Mathilde Rumeau, Sead Chadi, Frederic Pepke, Martin Beaumont, Cláudia M. Vicente, Agathe Juppeau, Céline Vandecasteele, Laurent Cauquil, Géraldine Pascal, Philippe Langella, Christelle Knudsen, Sylvie Combes, Rebeca Martín   +12 more
doaj   +1 more source

Secretor status-dependent modulation of in vitro immune responses by human milk oligosaccharides

Frontiers in Nutrition
IntroductionHuman milk oligosaccharides (HMOs) are structurally diverse carbohydrates found in high concentrations in human milk, supporting infant immune development and gut microbiota colonization.
Marit Zuurveld, Anneke Hellinga, Anneke Hellinga, Kennedy Spann, Lars Bode, Belinda van’t Land, Belinda van’t Land, Johan Garssen, Johan Garssen   +8 more
doaj   +1 more source

Efficient production of 2′-fucosyllactose in unconventional yeast Yarrowia lipolytica

, 2023
2′-Fucosyllactose (2′-FL) has great application value as a nutritional component and the whole cell biosynthesis of 2′-FL has become the focus of current research.
Qingsheng Qi, Yan Zhang, Haiyan Liu, Jin Hou, Mengmeng Liu, Xuejing Zhang   +5 more
core   +1 more source

Screening of Human Milk Oligosaccharide Combinations for Immunomodulatory Activity and Immunomodulatory Effects of Milk Formula Containing Them on Mice [PDF]

Shipin Kexue
Objective: To determine the immunoenhancing activity of ternary mixtures of 2’-fucosyllactose (2’-FL), fructooligosaccharide (FOS), and galactooligosaccharide (GOS) at different ratios and to validate the immunoregulatory effects of milk formula ...
MENG Liping, YANG Chang, XU Xiaomin, WANG Meihua, SHI Hanxu, YE Wanyun, LIU Siyuan, QIAN Wentao, LI Hongliang, XU Yajun
doaj   +1 more source

Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides

, 2016
Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2'-fucosyllactose (2'FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We
Koromyslova, A, Jennewein, S, Hansman, GS, Schroten, H, Singh, BK, Weichert, S, Hansman, S   +6 more
core   +1 more source

A review of human milk oligosaccharide concentrations of breast milk for infants and young children through 24 months of age

Frontiers in Pediatrics
The World Health Organization and American Academy of Pediatrics both support continued breastfeeding beyond 12 months of age up to 24 months of age or beyond. Human milk oligosaccharides (HMOs) are the third most abundant solid component in breast milk.
Adam D. Kenney, Anice Sabag-Daigle, Mary-Margaret Stoecklein, Rachael H. Buck, Elizabeth J. Reverri   +4 more
doaj   +1 more source

Production of fucosyllactose with a fucosidase from Aspergillus niger

, 2017
The interest on Human Milk Oligosaccharides (HMOs) has been increasing throughout the last years due to their reported beneficial effects on the infant’s nutrition.
Ruvalcaba Medrano, Marcela
core   +1 more source