Results 141 to 150 of about 2,717 (170)

Electrophilic metabolites of 3-methylindole as toxic intermediates in pulmonary oedema

Xenobiotica, 1984
[methyl-14C]-3-Methylindole (3MI) was incubated with goat-lung microsomes, an NADPH-generating system and glutathione. An adduct between an oxidative metabolite of 3MI and glutathione was formed only when the complete system was employed. The adduct, which was detected by u.v. absorbance and scintillation counting of h.p.l.c. fractions, was purified to
M R, Nocerini, J R, Carlson, G S, Yost
openaire   +2 more sources

Alkylation of bronchiolar epithelial cells by 3-methylindole metabolites in the horse

Toxicology Letters, 1985
Autoradiographs of horse-lung explants incubated with [3H]3-methylindole (3MI) showed 8 times greater labeling per area to bronchiolar epithelial cells than to the interalveolar septa. Incubations of horse-lung microsomes with [14C]3MI resulted in alkylation of microsomal proteins, which could be reduced by exogenous glutathione.
G M, Becker, M R, Nocerini, J R, Carlson, R G, Breeze   +3 more
openaire   +2 more sources

Organ-selective switching of 3-methylindole toxicity by glutathione depletion

Toxicology and Applied Pharmacology, 1990
A high dose (550 mg/kg) of 3-methylindole (3MI) specifically damaged pulmonary tissue in Swiss-Webster mice without causing any hepatic or renal necrosis. When a glutathione depleter, L-buthionine-(S,R)-sulfoximine (BSO, 1.0 mmol/kg), was administered to mice 3 hr before a low dose of 3-methylindole (75 mg/kg), significant renal damage was observed by ...
G S, Yost, D J, Kuntz, L D, McGill
openaire   +2 more sources

Pulmonary lesions induced by 3-methylindole in mice.

The American journal of pathology, 1985
The morphogenesis of pulmonary lesions and associated edema induced by the pulmonary toxicant 3-methylindole (3-MI) was studied by combined light and transmission electron microscopy. Weanling male CD-1 mice received 3-MI dissolved in corn oil by intraperitoneal injection and were studied at intervals from 2 to 360 hours after treatment.
S K, Durham, W L, Castleman
openaire   +1 more source

Duration of inhibition of 3-methylindole production by monensin.

Journal of animal science, 1985
A series of in vitro and in vivo trials was conducted to determine if continuous monensin feeding for up to 56 d would reduce ruminal conversion of L-tryptophan (TRP) to 3-methylindole (3MI). Fourteen mature beef cows were adapted to a maintenance diet for 3 wk. In trial I, the sampling time to optimize 3MI production was determined.
D C, Honeyfield, J R, Carlson, M R, Nocerini, R G, Breeze   +3 more
openaire   +1 more source

3-methylindole-induced pulmonary injury in goats.

The American journal of pathology, 1977
Ruminal administration of 3-methylindole in goats severe pulmonary edema and respiratory distress. Electron microscopic studies of lungs reveal extensive degeneration and necrosis of alveolar membranous pneumocytes and bronchiolar epithelium. The necrosis of the pneumocytes is followed by proliferation of granular pneumocytes, which repopulate the ...
T W, Huang, J R, Carlson, T M, Bray, B J, Bradley   +3 more
openaire   +1 more source

Mechanisms of 3-methylindole pneumotoxicity

Chemical Research in Toxicology, 1989
openaire   +2 more sources

3-Methylindole invades the lungs

Food and Cosmetics Toxicology, 1979
openaire   +1 more source

Study of hydrogenation and dehydrogenation of 1-methylindole for reversible onboard hydrogen storage application

International Journal of Hydrogen Energy, 2018
Hanzhong Ke, Dandan Xie, Guoe Cheng
exaly  

Toxicity of 3-methylindole to the human lung?

Food and Chemical Toxicology, 1997
openaire   +1 more source