Results 121 to 130 of about 2,717 (170)
Some of the next articles are maybe not open access.
Utilization of Chloroagetone in the Synthesis of 3-Methylindoles
Synthetic Communications, 1992Abstract Syntheses of 3-methylindoles 2 and 5 are described starting from chloroacetone and the corresponding monoalkylated anilines utilizing a modified alkylation-cyclization sequence. Compound 5 was converted in high yield into a very useful oxindole 7 in two steps.
Russell Underwood +3 more
openaire +1 more source
3‐methylindole as a model of equine obstructive lung disease
Equine Veterinary Journal, 1984Summary 3‐methylindole was administered orally and intravenously to horses and ponies in order to determine the ability of this chemical to provide a model of equine pulmonary disease. Both routes produced a severe and sometimes fatal pulmonary disease, characterised by bronchiolitis.
R G, Breeze, C M, Brown, M A, Turk
openaire +2 more sources
Nutrition and 3-Methylindole-Induced Lung Injury
1983Damage to lung tissue can result from exposure to a variety of chemicals in the internal and external environment. Chemicals gain access to the lung through the large alveolar surface areas (1 m2/kg body wt.), in the case of inhaled agents, and the extensive perfusion of the lung with blood in the case of blood-borne chemicals (Witschi, 1976; Witschi ...
J R, Carlson, T M, Bray
openaire +2 more sources
Coinage metal complexes of 2-diphenylphosphino-3-methylindole
Dalton Transactions, 2011Coordination of P,N indolyl-phosphine ligands to Au(I), Ag(I) and Cu(I) metal ions under weakly basic conditions results in easy deprotonation of the indolyl N-H function and effective formation of a family of homo- and heterobimetallic complexes MM'(PPh(2)C(9)H(7)N)(2) (M = M' = Au (2), Ag (5); M = Au, M' = Cu (3), Ag (4)). The latter (4) exists as an
Igor O, Koshevoy +5 more
openaire +2 more sources
Pharmacokinetics of small doses of 3-methylindole given to horses
American Journal of Veterinary Research, 1985SUMMARY The pharmacokinetics of 3-methylindole (3MI) given orally in 2 doses (10 mg/kg and 20 mg/kg) to horses were determined. The pharmacokinetic plasma-concentration profiles for 3MI (10- and 20-mg/kg dosages) in horses were represented by a 2-compartment open model with first-order absorption, as determined by nonlinear least-squares regression ...
D E, Thomas, R E, Beadle
openaire +2 more sources
The covalent binding of 3-methylindole metabolites to bovine tissue
Life Sciences, 1980Abstract Tritiated 3-methylindole (3MI) was administered intravenously to calves. Total and covalent bound radioactivity were measured in different tissues. Pulmonary tissue showed the highest concentration of covalent bound radioactivity. (G- 3 H) or (methyl- 14 C) 3MI became covalently bound to microsomal protein when incubated with bovine lung ...
M S, Hanafy, J A, Bogan
openaire +2 more sources
Pathophysiologic Studies of Calves Given 3-Methylindole Intraruminally
American Journal of Veterinary Research, 1979SUMMARY Intraruminal administration of 0.25 g of 3-methylindole (3MI; skatole/kg of body weight) to seven young calves generally caused mild respiratory signs and lesions, accompanied by only slight changes in cardiopulmonary function. Moderate depression, trembling, and irregular respiratory rate were observed between postadministration hours (pah) 6 ...
L M, Cornelius +3 more
openaire +2 more sources
3-Methylindole-Induced Nasal Mucosal Damage in Mice
Veterinary Pathology, 19873-Methylindole (3MI) damages nasal olfactory epithelium in mice. Lesions were studied histologically from 30 minutes to 28 days after intraperitoneal injection of 400 mg 3MI/kg. Cellular swelling was apparent in olfactory epithelium by 6 hours after injection of 3MI, while respiratory epithelium was normal.
M A, Turk, W G, Henk, W, Flory
openaire +2 more sources
Impairment of sympathetic pulmonary vasoconstriction by 3-methylindole in cattle
American Journal of Veterinary Research, 1985SUMMARY Sixteen Holstein cattle allotted into 4 groups (4 cattle/group) were each given a single oral dosage of 0.2 g of 3-methylindole (3MI)/kg of body weight. The groups were killed at 12, 24, 48, and 72 hours, respectively, after 3MI administration.
M S, Perry, O S, Atwal, P, Eyre
openaire +2 more sources
Effects of phenobarbital treatment on 3-methylindole toxicosis in ponies
American Journal of Veterinary Research, 1986SUMMARY To study the role of cytochrome P-450-dependent mixed function oxidase reactions in equine 3-methylindole (3MI) toxicosis, ponies were given 20 mg of phenobarbital/kg of body weight at 72, 60, 48, 36, and 24 hours before 100 mg of oral 3MI/kg to induce cytochrome P-450 or no treatment (controls).
M A, Turk, D E, Thomas
openaire +2 more sources