Results 111 to 120 of about 2,717 (170)
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Metabolism of 3-methylindole by a methanogenic consortium
Applied and Environmental Microbiology, 1992A methanogenic 3-methylindole (3-MI)-degrading consortium, enriched from wetland soil, completely mineralized 3-MI. Degradation proceeded through an initial hydroxylation reaction forming 3-methyloxindole. The consortium was unable to degrade oxindole or isatin, suggesting a new pathway for 3-MI fermentation.
Berry, DF, Gu, JD
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The metabolism and disposition of 3-methylindole in goats
Life Sciences, 1979Abstract The metabolism and disposition of 3-methylindole (3MI), a ruminal metabolite of L-tryptophan which causes acute pulmonary edema and emphysema (APE) when administered to cattle, goats, and sheep was investigated. Goats given jugular infusions of [14C] 3MI excreted 87 to 92% of the infused radioactivity in the urine, 0.4 to 0.9% in expired air,
A C, Hammond, J R, Carlson, J D, Willett
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The metabolic basis of 3-methylindole-induced pneumotoxicity
Pharmacology & Therapeutics, 19903-Methylindole (3MI), an abnormal metabolite of tryptophan, causes acute pulmonary edema and emphysema. 3MI toxicity is species-, tissue- and cell-specific and is an excellent model for understanding the processes of chemically-induced lung injury. Experimental evidence showed that 3MI is metabolically activated by both microsomal cytochrome P-450 ...
T M, Bray, J B, Kirkland
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Chemical Physics, 2001
Abstract We report theoretical calculations of vibrational absorption and Raman spectra for the tryptophan analog 3-methylindole using density functional theory, the Becke3LYP hybrid functional, and the TZ/2P basis set. These results are compared to experimentally measured vibrational absorption and Raman spectra for 3-methylindole.
S.W. Bunte +7 more
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Abstract We report theoretical calculations of vibrational absorption and Raman spectra for the tryptophan analog 3-methylindole using density functional theory, the Becke3LYP hybrid functional, and the TZ/2P basis set. These results are compared to experimentally measured vibrational absorption and Raman spectra for 3-methylindole.
S.W. Bunte +7 more
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3-Methylindole-induced pulmonary toxicosis in ponies
American Journal of Veterinary Research, 1982SUMMARY In unanesthetized ponies, arterial blood gas tensions, pulmonary mechanics, and lung volumes were determined before and 24 to 48 hours after oral administration of 500 ml of corn oil or 100 mg of 3-methylindole (3MI)/kg of body weight in 500 ml of com oil.
F J, Derksen +3 more
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Stark absorption spectroscopy of indole and 3-methylindole
The Journal of Chemical Physics, 2004Indole and 3-methylindole (3-MI) doped into a polymethylmethacrylate (PMMA) film are studied by the Stark absorption (electroabsorption) spectroscopy. The La1 and Lb1 absorption bands are distinguished and the change in permanent dipole moment on La1 excitation is determined by a model fit to the measured absorption and electroabsorption spectra ...
Erko, Jalviste, Nobuhiro, Ohta
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Detection and Characterization of DNA Adducts of 3-Methylindole
Chemical Research in Toxicology, 2001The pneumotoxin 3-methylindole is metabolized to the reactive intermediate 3-methyleneindolenine which has been shown to form adducts with glutathione and proteins. Reported here is the synthesis, detection, and characterization of nucleoside adducts of 3-methylindole.
K A, Regal +4 more
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Improvements in the Acylation of 3-Methylindole Using Amberlyst-15
Letters in Organic Chemistry, 2020A simple and efficient methodology for Friedel-Crafts acylation of 3-methylindole using Amberlyst 15 resin as catalyst is described. This methodology shows good selectivity towards the formation of the products of 2-acylation, (3-methyl-1H-indol-2-yl)ketones.
Vargas, Dario Andres +2 more
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Photooxidation of 3-Methylindoles
Australian Journal of Chemistry, 1977Ultraviolet photolysis of 3-methylindole gives 2-formamidoacetophenone (2?-acetylformanilide) and 3-methylindole-2-carbaldehyde whereas photolysis of 2-ethyl-3-methylindole gives 2-acetyl-3-methylindole and 2-propionamidoacetophenone (2?-acetylpropionanilide).
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Metabolism of 3-methylindole in human tissues.
Drug Metabolism and Disposition, 1991Bioactivation of 3-methylindole (3MI), a highly selective pneumotoxin in goats, was investigated in human lung and liver tissues in order to provide information about the susceptibility of humans to 3MI toxicity. Human lung microsomes were prepared from eight organ transplantation donors and liver microsomes from one of the donors were utilized.
W, Ruangyuttikarn +2 more
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