Results 41 to 50 of about 4,889,916 (279)
Architectural proteins: regulators of 3D genome organization in cell fate [PDF]
Trends in Cell Biology, 2014 The relation between alterations in chromatin structure and changes in gene expression during cell differentiation has served as a paradigm to understand the link between genome organization and function. Yet, the factors involved and the mechanisms by which the 3D organization of the nucleus is established remain poorly understood.
Elena, Gómez-Díaz, Victor G, Corces
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Genome architecture mapping detects transcriptionally active, multiway chromatin contacts
, 2023 Genome architecture mapping (GAM) enables understanding of 3D genome structure in the nucleus. We directly compared multiplex-GAM and Hi-C data and found that local chromatin interactions were generally detected by both methods, but active genomic ...
Thieme, C.J., Pombo, A.
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Rearrangement of T Cell genome architecture regulates GVHD
iScience, 2022 Summary: WAPL, cohesin’s DNA release factor, regulates three-dimensional (3D) chromatin architecture. The 3D chromatin structure and its relevance to mature T cell functions is not well understood.
Yaping Sun +10 more
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Nature Communications, 2021 The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi +19 more
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Reconstruction of 3D genome architecture via a two-stage algorithm. [PDF]
BMC Bioinformatics, 2015 The three-dimensional (3D) configuration of chromosomes within the eukaryote nucleus is an important factor for several cellular functions, including gene expression regulation, and has also been linked with cancer-causing translocation events. While visualization of such architecture remains limited to low resolutions, the ability to infer structures ...
Segal MR, Bengtsson HL.
europepmc +4 more sources
Nature Communications, 2022 Two main mechanisms have been proposed to shape 3D genome architecture - loop extrusion and phase separation. Here the authors combine these mechanisms in polymer models in a manner that best fits 3D genome, based on both Hi-C and super-resolution locus ...
Mattia Conte +6 more
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Genome architecture and selective signals compensatorily shape plastic response to a new environment
The Innovation, 2023 Transcriptional plasticity interacts with natural selection in complex ways and is crucial for the survival of species under rapid climate change. How 3D genome architecture affects transcriptional plasticity and its interaction with genetic adaptation ...
Ao Li +11 more
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Genome 3D-architecture: Its plasticity in relation to function [PDF]
Journal of Biosciences, 2018 The genome of higher eukaryotes is non-randomly organized in the interphase nucleus. However, notwithstanding the absence of membrane bound sub-compartments, the nucleus coordinates a number of functions largely by organizing chromatin in a non-random but dynamic manner.
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3D genomic architecture reveals that neocentromeres associate with heterochromatin regions [PDF]
Journal of Cell Biology, 2018 The centromere is an important genomic locus for chromosomal segregation. Although the centromere is specified by sequence-independent epigenetic mechanisms in most organisms, it is usually composed of highly repetitive sequences, which associate with heterochromatin.
Kohei Nishimura +4 more
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, 2021 The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia ...
The American Genome Center
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