Results 31 to 40 of about 4,889,916 (279)

MyoD is a 3D genome structure organizer for muscle cell identity

Nature Communications, 2022
Pioneer transcription factors (TFs) have been proposed to act as protein anchors to orchestrate cell type-specific 3D genome architecture. MyoD is a pioneer TF for myogenic lineage specification.
Ruiting Wang, Fengling Chen, Qian Chen, Xin Wan, Minglei Shi, Antony K. Chen, Zhao Ma, Guohong Li, Min Wang, Yachen Ying, Qinyao Liu, Hu Li, Xu Zhang, Jinbiao Ma, Jiayun Zhong, Meihong Chen, Michael Q. Zhang, Yong Zhang, Yang Chen, Dahai Zhu   +19 more
doaj   +1 more source

Crenarchaeal 3D Genome: A Prototypical Chromosome Architecture for Eukaryotes [PDF]

Cell, 2019
In this issue of Cell, Takemata et al. demonstrate that coalescin (ClsN), an archaeal condensin ortholog, facilitates higher-level organization of chromosomes in crenarchaea that bears greater similarity to metazoans than bacteria. Their study unravels biological function for chromosome organization in Archaea and provides insights into the evolution ...
Xu, Feng, Qihong, Huang, Qunxin, She
openaire   +2 more sources

SATB2 organizes the 3D genome architecture of cognition in cortical neurons. [PDF]

Mol Cell
The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and accessibility in control versus SATB2-deficient cortical neurons. We find that SATB2 affects the chromatin looping between enhancers and promoters of neuronal-activity ...
Wahl N, Espeso-Gil S, Chietera P, Nagel A, Laighneach A, Morris DW, Rajarajan P, Akbarian S, Dechant G, Apostolova G.   +9 more
europepmc   +3 more sources

Orca: Sequence-based modeling of genome 3D architecture from kilobase to chromosome-scale (Part3)

, 2021
This dataset (Part 3) provides resource files required for using the manuscript code of Orca. Precomputed results are also provided in a separate file.
Zhou, Jian
core   +1 more source

Initial Genomics of the Human Nucleolus [PDF]

, 2010
We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different ...
Laengst, Gernot, Santoyo-Lopez, Javier, Bálint Péterfia, Montaner David, Längst, Gernot, Conesa, Ana, Javier Santoyo-Lopez, Irina Solovei, Solovei, Irina, Dopazo, Joaquin, Cremer Thomas, Thomas Cremer, Joaquin Dopazo, Ignacio Medina, Nemeth, Attila, Medina, Ignacio, Längst Gernot, Akhtar, Asifa, Medina Ignacio, Németh Attila, Peterfia, Balint, Gernot Längst, Cremer, Thomas, Péterfia Bálint, Montaner, David, Solovei Irina, Attila Németh, Ana Conesa, Santoyo-Lopez Javier, Dopazo Joaquin, Conesa Ana, David Montaner   +31 more
core   +2 more sources

of The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes

, 2016
of The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse ...
Christel Kockx (348589), Frank Grosveld (63633), Nick Kepper (3606581), A. Ali Imam (3606587), Harmen Werken (3606578), Tobias Knoch (3606497), Petros Kolovos (188878), Wilfred IJcken (3606590), Rutger Brouwer (3606575), Kerstin Wendt (3606569), Michael Lesnussa (3606584), Jessica Zuin (523108), Malte Wachsmuth (269155), Anis Abuseiris (3606572)   +13 more
core   +4 more sources

At the Crossroad of Gene Regulation and Genome Organization: Potential Roles for ATP-Dependent Chromatin Remodelers in the Regulation of CTCF-Mediated 3D Architecture

Biology, 2021
In higher order organisms, the genome is assembled into a protein-dense structure called chromatin. Chromatin is spatially organized in the nucleus through hierarchical folding, which is tightly regulated both in cycling cells and quiescent cells ...
Aktan Alpsoy, Surbhi Sood, Emily C. Dykhuizen   +2 more
doaj   +1 more source

Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin.

PLoS Genetics, 2020
Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Yuh Chwen G Lee, Yuki Ogiyama, Nuno M C Martins, Brian J Beliveau, David Acevedo, C-Ting Wu, Giacomo Cavalli, Gary H Karpen   +7 more
doaj   +1 more source

Reorganization of the 3D chromatin architecture of rice genomes during heat stress [PDF]

BMC Biology, 2021
Abstract Background The three-dimensional spatial organization of the genome plays important roles in chromatin accessibility and gene expression in multiple biological processes and has been reported to be altered in response to environmental stress.
Zhe Liang, Qian Zhang, Changmian Ji, Guihua Hu, Pingxian Zhang, Yifan Wang, Liwen Yang, Xiaofeng Gu   +7 more
openaire   +3 more sources

DeCOOC Deconvoluted Hi‐C Map Characterizes the Chromatin Architecture of Cells in Physiologically Distinctive Tissues

Advanced Science, 2023
Deciphering variations in chromosome conformations based on bulk three‐dimensional (3D) genomic data from heterogenous tissues is a key to understanding cell‐type specific genome architecture and dynamics.
Junmei Wang, Lu Lu, Shiqi Zheng, Danyang Wang, Long Jin, Qing Zhang, Mingzhou Li, Zhihua Zhang   +7 more
doaj   +1 more source